Patents by Inventor Xiangdong W. Yang

Xiangdong W. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A Cell-Based Seeding Assay for Huntingtin Aggregation
    Publication number: 20200255487
    Abstract: The invention provides a sensitive cell-based assay, in which stably expressed mutant Huntingtin (mHTT) fragments serve as biosensors to detect mHTT species present in biosamples or can be used to identify novel compounds for use as therapeutics for the treatment of HD.
    Type: Application
    Filed: October 12, 2018
    Publication date: August 13, 2020
    Inventors: Xiangdong W. YANG, Chung-Ying LEE, Nan WANG, Robert DAMOISEAUX
  • Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof
    Patent number: 6821759
    Abstract: A simple method for modifying genes in a recombination deficient host cell is disclosed. Such modifications include generating insertions, deletions, substitutions, and/or point mutations at any chosen site in the independent origin based cloning vector. The modified gene is contained in an independent origin based cloning vector that is used to introduce a modified heterologous gene into a cell. Such a modified vector may be used in the production of a germline transmitted transgenic animal, or in gene targeting protocols in eukaryotic cells. In particular, high throughput methodology is provided for generating the modified the independent origin based cloning vectors of the present invention.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: November 23, 2004
    Assignee: The Rockefeller University
    Inventors: Nathaniel Heintz, Peter Model, Xiangdong W. Yang, Shiaoching Gong
  • Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof
    Patent number: 6485912
    Abstract: A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACS) in novel gene trapping protocols. Targeted gene trapping by homologous recombination, and random gene trapping with the use of a transposon system are exemplified. Included in the invention are methods of preparing a gene map from BBPAC contigs, the resulting gene maps, methods of constructing a cDNA library from BBPAC contigs, and the resulting cDNA libraries.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: November 26, 2002
    Assignee: The Rockefeller University
    Inventors: Nathaniel Heintz, Weining Jiang, Xiangdong W. Yang
  • Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof
    Patent number: 6156574
    Abstract: A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACs) in novel gene trapping protocols. Targeted gene trapping by homologous recombination, and random gene trapping with the use of a transposon system are exemplified. Included in the invention are methods of preparing a gene map from BBPAC contigs, the resulting gene maps, methods of constructing a cDNA library from BBPAC contigs, and the resulting cDNA libraries.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: December 5, 2000
    Assignee: The Rockefeller University
    Inventors: Nathaniel Heintz, Weining Jiang, Xiangdong W. Yang
  • Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof
    Patent number: 6143566
    Abstract: A simple method for modifying genes in a recombination deficient host cell is disclosed. Such modifications include generating insertion, deletions, substitutions, and/or point mutations at any chosen site in the independent origin based cloning vector. The modified gene can be contained in an independent origin based cloning vector that is used to introduce a modified heterologous gene into a cell. Such a modified vector may be used in the production of a germline transmitted transgenic animal, or in gene targeting protocols in eukaryotic cells.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: November 7, 2000
    Assignee: The Rockfeller University
    Inventors: Nathaniel Heintz, Peter Model, Xiangdong W. Yang
  • Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof
    Patent number: 6130090
    Abstract: A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACs) in novel gene trapping protocols. Targeted gene trapping by homologous recombination, and random gene trapping with the use of a transposon system are exemplified. Included in the invention are methods of preparing a gene map from BBPAC contigs, the resulting gene maps, methods of constructing a cDNA library from BBPAC contigs, and the resulting cDNA libraries.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: October 10, 2000
    Assignee: The Rockefeller University
    Inventors: Nathaniel Heintz, Weining Jiang, Xiangdong W. Yang