Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The invention relates to a hybrid power drive system, comprising: an internal combustion engine having a crankshaft; a first electric motor (14), wherein the first electric motor (14) is an outer rotor electric motor, and comprises an outer rotor (14.2) that is rigidly connected to the crankshaft and rotates together with the crankshaft; a transmission (15) comprising an input shaft (20); and a clutch (18) that is provided between the first electric motor (14) and the transmission (15), and is connected to the input shaft (20) of the transmission. The clutch (18) is configured to be capable of switching between the following positions: an engagement position where the clutch (18) is engaged with the outer rotor (14.2); and a separation position where the clutch (18) is separated from the outer rotor (14.2). The present system is simple in structure, high in efficiency, and low in manufacturing and maintenance costs.

Abstract: A helper epitope peptide is obtained by means of replacing one or two amino acid residues in the helper T cell epitope PADRE with 4-nitrophenylalanine. The helper epitope peptide is effective for enhancing the immunogenicity of an antigen or antigenic epitope or for preparing or constructing a vaccine, and a fusion antigen formed by connecting the helper epitope peptide to an antigen or an antigenic epitope.

Abstract: A polymer composition comprising (i) 4.95 to 95.0 wt. % low density polyethylene (LDPE) (component (i), herein after); (ii) 4.95 to 95.0 wt. % of a polypropylene (component (ii), herein after); and (iii) 0.00 to 30.0 wt. % of a styrene block copolymer (component (iii), herein after); (iv) 0.05 to 10.0 wt. % of an aliphatic, preferably alkyl, functionalized inorganic nanoparticle filler (component (iv), herein after); whereby the weight percentages (wt. %) are expressed relative to the total weight of the polymer composition.

Abstract: The present invention relates to the technical field of polymer material manufacturing, and in particular to a biodegradable material and preparation method thereof. The biodegradable material is prepared by using a resin comprising only PHA, and further incorporating suitable fillers and/or auxiliary agents. The biodegradable material of the present invention exhibits excellent performance in that it can swiftly and thoroughly degrade in natural environments, ensuring complete environmental friendliness throughout its life cycle. As a result, it facilitates the reduction of white environmental pollution caused by disposable plastic products and the lowering of petroleum consumption.

Abstract: A clutch arrangement for a hybrid vehicle powertrain including an input shaft to be connected to a crankshaft of an internal combustion engine, an output shaft for connection to a transmission, a one-way clutch comprising an inner race connected to rotate with the input shaft and an outer race, a coupling hub rotationally coupled with the output shaft, a synchronizer ring arranged between the coupling hub and the one-way clutch, the synchronizer ring cooperating with the outer race of the one-way clutch, and a coupling sleeve unit that is selectively and axially moveable across the coupling hub. The synchronizer ring and the outer race include three positions, a neutral position, a first position, and a second position.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A clutch arrangement for a hybrid vehicle powertrain, comprises: an input shaft (30) to be connected to a crankshaft (26) of an internal combustion engine (12); an output shaft (32) for connection to a transmission (20); a one-way clutch (50) for comprising an inner race (52) connected to rotate with the input shaft (30) and an outer race (54); a coupling hub (58) rotationally coupled with the output shaft (32); and a synchronizer ring (60) arranged between the coupling hub (58) and the one-way clutch (50), the synchronizer ring cooperating with the outer race of the one-way clutch.

Abstract: The invention provides a polymer composition comprising a) a polyethylene; and b) a conjugated aromatic polymer. The invention also relates to cables comprising said polymer composition and the use of the polymer composition in the manufacture of an insulation layer of cable.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The invention relates to a hybrid power drive system, comprising: an internal combustion engine having a crankshaft; a first electric motor (14), wherein the first electric motor (14) is an outer rotor electric motor, and comprises an outer rotor (14.2) that is rigidly connected to the crankshaft and rotates together with the crankshaft; a transmission (15) comprising an input shaft (20); and a clutch (18) that is provided between the first electric motor (14) and the transmission (15), and is connected to the input shaft (20) of the transmission. The clutch (18) is configured to be capable of switching between the following positions: an engagement position where the clutch (18) is engaged with the outer rotor (14.2); and a separation position where the clutch (18) is separated from the outer rotor (14.2). The present system is simple in structure, high in efficiency, and low in manufacturing and maintenance costs.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A vehicle high-voltage charging system includes: an inverter connected to a rechargeable battery; a motor connected to the inverter and configured to supply power, which is provided to a neutral point of the motor, to the inverter; a first relay having one end connected to the charging power input terminal and an opposite end; a neutral point capacitor arranged on a by-pass path, wherein a first end of the by-pass path is connected to the neutral point and a charging power input terminal to which DC charging power is adapted to input, and a second end of the by-pass path is connected to the rechargeable battery and the opposite end of the opposite end of the first relay; characterized in that the charging system further comprises a second relay, wherein the in series second relay arranged in the by-pass path and with the neutral point capacitor.