Abstract: Embodiments of the present application disclose a method and an apparatus for pushing information. One embodiment of the method comprises: in response to the receipt of an information push request sent by a user by means of a terminal, determining object information about at least one object associated with user information included in the information push request; determining target push information according to the user information, the object information, and a pre-established information determination model, the information determination model being used for characterizing a correlation between user information, object information, and target push information; and pushing the target push information to the terminal for the user to view by means of the terminal.

Abstract: Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for directing proteins to specific loci in the genome of an organism, including the steps of providing a fusion protein comprising a DNA localization component and an effector molecule. Preferred embodiments of the disclosure include, but are not limited to, the following fusion proteins: dSaCas9-Clo051, dCas9-Clo051, Xanthomonas-TALE-Clo051, and Ralstonia-TALE-Clo051.

Abstract: The present disclosure is directed to compositions and methods for the treatment of Metabolic Liver Disorders. The compositions and methods can comprise an adeno-associated virus (AAV) piggyBac polynucleotide comprising a transgene. The transgene may comprise ornithine transcarbamylase (OTC) or methylmalonyl-CoA mutase (MUT1).

Abstract: Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for directing proteins to specific loci in the genome of an organism, including the steps of providing a fusion protein comprising a DNA localization component and an effector molecule. Preferred embodiments of the disclosure include, but are not limited to, the following fusion proteins: dSaCas9-Clo051, dCas9-Clo051, Xanthomonas-TALE-Clo051, and Ralstonia-TALE-Clo051.

Abstract: Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for directing proteins to specific loci in the genome of an organism, including the steps of providing a fusion protein comprising a DNA localization component and an effector molecule. Preferred embodiments of the disclosure include, but are not limited to, the following fusion proteins: dSaCas9-Clo051, dCas9-Clo051, Xanthomonas-TALE-Clo051, and Ralstonia-TALE-Clo051.

Abstract: Disclosed are methods of facilitating the interaction of a first and a second component, the method including the use of an antibody fragment and an epitope tag. The antibody fragment may be bound to a first component, while the epitope tag may be bound to a second component. The antibody fragment may have a binding specificity for the epitope tag sufficient to cause an interaction between the antibody fragment and the epitope tag.

Abstract: Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for directing proteins to specific loci in the genome of an organism, including the steps of providing a DNA localization component and an effector molecule, wherein the DNA localization component and the effector molecule are capable of being operatively linked via a non-covalent linkage.

Abstract: The present invention provides in one aspect a composition having at least one metal complex, such that the metal complex comprises at least one metal atom, a phenanthroline-based first ligand and a second ligand comprising at least one acidic group, and at least two coordinative nitrogen atoms capable of simultaneous binding to the metal atom. This composition may be disposed on a semiconductor layer which is further disposed on an electrically conductive surface to provide a dye-sensitized electrode. The dye-sensitized electrode can be assembled together with a counter electrode and a redox electrolyte to provide a dye-sensitized solar cell.