Patents by Inventor Xiangjiang WANG

Xiangjiang WANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR EXTRACTING AND SEQUENCING SINGLE-STRANDED DNA AND RNA FROM NON-TREATED BIOSPECIMENS
    Publication number: 20230120072
    Abstract: Provided herein are hybrid capture-based methods to extract single-stranded DNA or RNA directly from non-treated biospecimens. The methods allow for the detection and analysis of unexplored short single-stranded DNA (sssDNA, mean length 50 nt) and ultrashort single-stranded DNA (ussDNA, mean length 15 nt) of human origin present in the biospecimen. The methods allow the discovery of unexplored short single-stranded DNA (sssDNA) in isolated red blood cells, which were believed to be deprived of nucleic acids because of the lack of a nucleus in mature red blood cells. The DNA or RNA extracted using the disclosed methods can be used as disease prognostic biomarkers and treatment predictive biomarkers.
    Type: Application
    Filed: December 18, 2020
    Publication date: April 20, 2023
    Applicant: William Marsh Rice University
    Inventors: David ZHANG, Ruojia WU, Peng DAI, Yuxuan CHENG, Xiangjiang WANG