Abstract: High-speed, easily maintained connectors and interconnection systems. An interconnection system includes a cable connector and a board connector that can mate with each other. The cable connector includes a housing and a flexible flat cable with a mating portion in the housing. The housing includes a conductive layer on an insulating body. The flexible flat cable includes a shielding layer electrically connected to the housing conductive layer. The board connector includes a main housing holding terminals, a cage outside the main housing, and an outer housing outside the cage. The cage can be electrically connected to the cable shielding layer through the housing conductive layer. An elastic conductive member can be disposed around the cable connector housing to facilitate interconnection between the cage and the housing conductive layer. Such techniques can enable high-speed, easy maintenance connectors and interconnection systems for harsh environments such as one presented by an automobile.

Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.

Abstract: Reliable high-speed, high-density cable connector. The cable connector comprises a housing and a conducting assembly removably connected to the housing. The conducting assembly includes at least one flexible flat cable. A terminal position assurance (TPA) device is disposed from a top of the housing and configured to secure the conducting assembly to the housing in a locked state and allow the removal of the conducting assembly in an unlocked state. A connector position assurance (CPA) device is disposed from a side of the housing and configured to secure to a mating component. Such techniques can enable reliable high-speed, high-density connectors with replaceable cables, which can be used in harsh environments such as one presented by an automobile.

Abstract: Reliable high-speed, high-density connectors and interconnection systems thereof. An interconnection system includes a plug connector and a receptacle connector. The plug connector comprises a housing assembly, a module, and a CPA device. The module includes densely disposed conductive pads. The module can include a circuit board with the conductive pads and high-speed data cables having ends mounted onto the conductive pads. The CPA device is disposed on the housing assembly, and configured for securing the plug connector to the receptacle connector. The CPA device can include locking features disposed on different sides of the housing assembly, which can improve reliability. The receptacle connector includes an outer housing having complementary locking features. The connectors can be electrically connected as long as a first locking feature in its locked position. Such techniques can enable interconnection systems for harsh environments such as one presented by an automobile.

Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.

Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.

Abstract: The present disclosure describes systems and methods for immunotherapies Immune cells can be engineered to exhibit enhanced half-life as compared to control cell (e.g., a non-engineered immune cell). Immune cells can be engineered to exhibit enhanced proliferation as compared to a control cell. Immune cells can be engineered to effectively and specifically target diseased cells (e.g., cancer cells) that a control cell otherwise is insufficient or unable to target. The engineered Immune cells disclosed herein can be engineered ex vivo, in vitro, and in some cases, in vivo. The engineered Immune cells that are prepared ex vivo or in vitro can be administered to a subject in need thereof to treat a disease (e.g., myeloma or solid tumors). The engineered Immune cells can be autologous to the subject. Alternatively, the engineered immune cells can be allogeneic to the subject.

Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.