Abstract: The present disclosure provides a checking method of a system start-up file. The method includes: acquiring the system start-up file and a mapping table from a system firmware partition; reading first check data and addressing data associated therewith from the mapping table; reading segmentation data corresponding to the first check data from the system start-up file according to the addressing data; determining whether the first check data is a first type or a second type; if it is the first type, determining whether the segmentation data is a repeated permutation of the first check data, and if not, a security error exists in the system start-up file; and if it is the second type, determining whether second check data, obtained by calculating the segmentation data according to a check algorithm, is consistent with the first check data, and if inconsistent, a security error exists in the system start-up file.

Abstract: The present invention discloses the application of aptamer in recognition and binding of alkaline phosphatase heterodimer. The present invention provides an aptamer or its derivative, the nucleotide sequence of which is shown in SEQ ID NO: 1 in the sequence listing. The present invention also provides a kit including an aptamer or a derivative thereof, and a carrier for fixing or coupling the aptamer or a derivative thereof, wherein the aptamer is a single-stranded DNA molecule having the nucleotide sequence as shown in SEQ ID NO: 1. The method for capturing and detecting circulating tumor cells, exosomes and free alkaline phosphatase in peripheral blood highly expressing alkaline phosphatase based on the aptamer magnetic nanoparticle technology of the present invention can achieve highly selective capture and detection of target cells, exosomes or free proteins.

Abstract: The present disclosure provides a checking method of a system start-up file. The method includes: acquiring the system start-up file and a mapping table from a system firmware partition; reading first check data and addressing data associated therewith from the mapping table; reading segmentation data corresponding to the first check data from the system start-up file according to the addressing data; determining whether the first check data is a first type or a second type; if it is the first type, determining whether the segmentation data is a repeated permutation of the first check data, and if not, a security error exists in the system start-up file; and if it is the second type, determining whether second check data, obtained by calculating the segmentation data according to a check algorithm, is consistent with the first check data, and if inconsistent, a security error exists in the system start-up file.

Abstract: A method for color correction of a pair of colorful stereo microscope images is provided, which transmits the color information of the foreground areas and the background area of the reference image to the aberrated image separately for avoiding transmission error of the color information of the varied areas of the pair of the images, thus sufficiently improves the accuracy of the color correction, reduces the difference between the color of the reference image and the color of the aberrated image, and well prepares for the stereo matching of the pair of colorful stereo microscope images as well as for the three-dimensional reconstruction and three-dimensional measurement; on the other hand, during the correction, the correcting procedure is provided automatically without manual work.

Abstract: A method for color correction of a pair of colorful stereo microscope images is provided, which transmits the color information of the foreground areas and the background area of the reference image to the aberrated image separately for avoiding transmission error of the color information of the varied areas of the pair of the images, thus sufficiently improves the accuracy of the color correction, reduces the difference between the color of the reference image and the color of the aberrated image, and well prepares for the stereo matching of the pair of colorful stereo microscope images as well as for the three-dimensional reconstruction and three-dimensional measurement; on the other hand, during the correction, the correcting procedure is provided automatically without manual work.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention provides methods and kits for separating and identifying alleles, and thereby the haplotype, in genomic DNA samples. The method generally involves hybridizing primers specific to polymorphic sites within the alleles to the DNA sample, elongating the primers by one or more nucleic acids, separating the elongated primers and identifying the alleles utilizing the elongated primer. The method also allows for a ligation of two primers, their separation and subsequent use in identifying the targeted allele. The method further provides that another primer can be used as a blocking site for elongation of the first primer such that a stretch of DNA that includes a polymorphic site is replicated and identified. The unextended or extended primers can be labeled so that the primer can be easily separated and/or identified.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to type II diabetes and obesity. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant type II diabetes and obesity associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

Abstract: The present invention provides methods for analyzing polymorphic nucleic acids using duplex separation and/or identification techniques. In the present methods one of the nucleic acids has a sequence which includes universal bases that correspond in position to one or more of the polymorphic positions of the polymorphic nucleic acid. The nucleic acid including the universal bases can either represent the polymorphic nucleic acid and hybridize with a reference strand, or act as a reference strand and hybridize with the polymorphic nucleic acid directly, to form a duplex. Separation and/or identification of the duplex from other duplexes and materials can then be performed.

Abstract: The present invention provides methods and kits for separating and identifying alleles, and thereby the haplotype, in genomic DNA samples. The method generally involves hybridizing primers specific to polymorphic sites within the alleles to the DNA sample, elongating the primers by one or more nucleic acids, separating the elongated primers and identifying the alleles utilizing the elongated primer. The method also allows for a ligation of two primers, their separation and subsequent use in identifying the targeted allele. The method further provides that another primer can be used as a blocking site for elongation of the first primer such that a stretch of DNA that includes a polymorphic site is replicated and identified. The unextended or extended primers can be labeled so that the primer can be easily separated and/or identified.