Patents by Inventor Xiangle ZHANG

Xiangle ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant foot-and-mouth disease virus with reduced immunosuppression activity, and preparation method and use thereof
    Patent number: 11952401
    Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: April 9, 2024
    Assignee: Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
    Inventors: Haixue Zheng, Fan Yang, Zixiang Zhu, Xiangle Zhang, Weijun Cao, Congcong Wang, Kangli Li, Huisheng Liu, Hong Tian, Keshan Zhang, Xiangtao Liu
  • Recombinant foot-and-mouth disease virus with reduced immunosuppression activity, and preparation method and use thereof
    Publication number: 20220017576
    Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 20, 2022
    Inventors: Haixue ZHENG, Fan YANG, Zixiang ZHU, Xiangle ZHANG, Weijun CAO, Congcong WANG, Kangli LI, Huisheng LIU, Hong TIAN, Keshan ZHANG, Xiangtao LIU