Abstract: The embodiments of the present disclosure provide a display substrate, a display panel, and a display device. The display substrate includes: a first base substrate, wherein a plurality of sub-pixel regions arranged in an array are provided on the first base substrate; and a reflective layer provided on one side of the first base substrate, wherein a surface of the reflective layer away from the first base substrate is formed to include a plurality of first bumps and a plurality of second bumps, and the first bump has a size greater than that of the second bump.

Abstract: A method of treating fatty liver-related diseases in a patient includes administering to the patient a therapeutically effective amount of medicament manufactured from a FGF21 polypeptide, FGF21 fusion protein, or dual-fusion protein of FGF21 polypeptide and GLP-1 or a functional variant thereof.

Abstract: The present disclosure provides a combined vaccine against human respiratory syncytial virus (RSV) infection and a method thereof for inducing immune response. The combined vaccine includes; a first composition including an immunologically effective dosage of a replication-deficient human adenovirus type 26 vector contains a nucleotide encoding an antigenic protein of RSV and a pharmaceutically acceptable vector; and a second composition including an immunologically effective dosage of a replication-deficient chimpanzee adenovirus type 63 vector contains a nucleotide encoding an antigenic protein of RSV and a pharmaceutically acceptable vector. The first composition is a primary immunization composition and the second composition is a booster immunization composition, or vice versa. In the present disclosure, the combined vaccine is used for inducing a protective immunity against RSV infection, and a method is provided for generating the protective immunity against RSV infection.

Abstract: A method and a system for imaging a dynamic scene, by time-spectrum mapping when a single chirped pulse probes the dynamic scene, storing temporal information at different wavelengths, spectral shearing, spatial encoding and reverse spectral shearing; spatiotemporal integration; and image reconstruction from a resulting captured snapshot, using a laser source configured to emit a linearly chirped laser probe pulse; an imaging unit; a shearing and reversing shearing unit; an encoder; a detector; and a computer; wherein the imaging unit is configured to record the linearly chirped laser probe pulse transmitted by the dynamic scene in a snapshot; the shearing and reversing shearing unit is configured to spectrally shears the linearly chirped laser pulses received from the imaging unit to the encoder, the detector records a compressed snapshot of a temporal information of the dynamic scene read out by the probe pulse; and the computer processes the snapshot and yields a(x,y,t) datacube of the dynamic scene.

Abstract: A method and a system method for real-time wide-field dynamic temperature sensing of an object, the method comprising producing wide-field illumination to upconverting nanoparticles at the object plane, collecting a light emitted by the upconverting nanoparticles, dividing a collected light into a reflected component and a transmitted component; imaging the reflected component into a first image, imaging the transmitted component into a second image; processing the images; and reconstruction of the object from resulting proceed images.

Abstract: Described herein are polymorphs comprising 2?,6-difluoro-5?-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]tri-azin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In another aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with sulfuric acid. Also described herein are methods of making and using the same.

Abstract: A system and a method for single-shot compressed optical-streaking ultra-high-speed imaging, the system comprising a spatial encoding module spatially encoding the transient event with a binary pseudo-random pattern into spatially encoded frames; a galvanometer scanner temporally shearing the spatially encoded frames; and a CMOS camera receiving the temporally sheared spatially encoded frames, during one exposure time of the camera, for reconstructing the transient event. The method comprises spatial encoding a transient event; temporal shearing resulting spatially encoded frames of the event, spatio-temporal integration, and reconstruction.

Abstract: A transmission electron microscopy system for imaging a sample, comprising: a pulse generator for generating an initial electron pulse towards the sample, the initial electron pulse to be propagated through the sample to obtain a transmitted electron pulse; an encoding device for encoding the transmitted electron pulse according to a predefined pattern to obtain an encoded electron pulse; a shearing device for temporally shearing the encoded electron pulse in a given direction to obtain a given electron pulse; a detector for detecting the given electron pulse to obtain a single image of the sample; and a datacube generator for determining a spatiotemporal datacube from the single image using the predefined pattern, and outputting the spatiotemporal datacube.

Abstract: A transmission electron microscopy system for imaging a sample, comprising: a pulse generator for generating an initial electron pulse towards the sample, the initial electron pulse to be propagated through the sample to obtain a transmitted electron pulse; an encoding device for encoding the transmitted electron pulse according to a predefined pattern to obtain an encoded electron pulse; a shearing device for temporally shearing the encoded electron pulse in a given direction to obtain a given electron pulse; a detector for detecting the given electron pulse to obtain a single image of the sample; and a datacube generator for determining a spatiotemporal datacube from the single image using the predefined pattern, and outputting the spatiotemporal datacube.