Abstract: A method and a system for imaging a dynamic scene, by time-spectrum mapping when a single chirped pulse probes the dynamic scene, storing temporal information at different wavelengths, spectral shearing, spatial encoding and reverse spectral shearing; spatiotemporal integration; and image reconstruction from a resulting captured snapshot, using a laser source configured to emit a linearly chirped laser probe pulse; an imaging unit; a shearing and reversing shearing unit; an encoder; a detector; and a computer; wherein the imaging unit is configured to record the linearly chirped laser probe pulse transmitted by the dynamic scene in a snapshot; the shearing and reversing shearing unit is configured to spectrally shears the linearly chirped laser pulses received from the imaging unit to the encoder, the detector records a compressed snapshot of a temporal information of the dynamic scene read out by the probe pulse; and the computer processes the snapshot and yields a(x,y,t) datacube of the dynamic scene.

Abstract: A system and a method for single-shot compressed optical-streaking ultra-high-speed imaging, the system comprising a spatial encoding module spatially encoding the transient event with a binary pseudo-random pattern into spatially encoded frames; a galvanometer scanner temporally shearing the spatially encoded frames; and a CMOS camera receiving the temporally sheared spatially encoded frames, during one exposure time of the camera, for reconstructing the transient event. The method comprises spatial encoding a transient event; temporal shearing resulting spatially encoded frames of the event, spatio-temporal integration, and reconstruction.

Abstract: The present invention relates to an electronic flexible and rigid endoscope system and method applicable to general practice. The system comprises: a data acquisition system, configured to acquire image data of a lesion site, and a data processing system, configured to process the image data from the data acquisition system. The data acquisition system comprises a handle end and an endoscope end, the endoscope end comprises an imaging insertion end and an operating end, the imaging insertion end enters the lesion site to acquire images of the lesion site, the operating end controls the action of the imaging insertion end, the handle end sends the image data acquired by the endoscope end to the data processing system, the data processing system comprises a data receiving module and an image processing module, and the data receiving module receives the image data acquired by the data acquisition system.

Abstract: This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a CD276 polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a CD276 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.

Abstract: A diffraction-gated real-time ultrahigh-speed mapping photography method and system, by probing a transient scene with a single-wavelength continuous-wave beam, imaging the probed transient scene, generating different replicated images of the transient scene at spatially separated positions by using a 4f imaging system and a spatial light modulator, and rescaling the images size onto a low-speed CMOS or CCD camera for example, synchronizing with the flipping of the spatial light modulator for recording images of the transient scene.

Abstract: A method and a system method for real-time wide-field dynamic temperature sensing of an object, the method comprising producing wide-field illumination to upconverting nanoparticles at the object plane, collecting a light emitted by the upconverting nanoparticles, dividing a collected light into a reflected component and a transmitted component, imaging the reflected component into a first image, imaging the transmitted component into a second image; processing the images; and reconstruction of the object from resulting proceed images.

Abstract: A method and a system for imaging a dynamic scene, by time-spectrum mapping when a single chirped pulse probes the dynamic scene, storing temporal information at different wavelengths, spectral shearing, spatial encoding and reverse spectral shearing; spatiotemporal integration; and image reconstruction from a resulting captured snapshot, using a laser source configured to emit a linearly chirped laser probe pulse; an imaging unit; a shearing and reversing shearing unit; an encoder; a detector; and a computer; wherein the imaging unit is configured to record the linearly chirped laser probe pulse transmitted by the dynamic scene in a snapshot; the shearing and reversing shearing unit is configured to spectrally shears the linearly chirped laser pulses received from the imaging unit to the encoder, the detector records a compressed snapshot of a temporal information of the dynamic scene read out by the probe pulse; and the computer processes the snapshot and yields a(x,y,t) datacube of the dynamic scene.

Abstract: A method and a system method for real-time wide-field dynamic temperature sensing of an object, the method comprising producing wide-field illumination to upconverting nanoparticles at the object plane, collecting a light emitted by the upconverting nanoparticles, dividing a collected light into a reflected component and a transmitted component; imaging the reflected component into a first image, imaging the transmitted component into a second image; processing the images; and reconstruction of the object from resulting proceed images.

Abstract: Described herein are polymorphs comprising 2?,6-difluoro-5?-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]tri-azin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In another aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with sulfuric acid. Also described herein are methods of making and using the same.

Abstract: A system and a method for single-shot compressed optical-streaking ultra-high-speed imaging, the system comprising a spatial encoding module spatially encoding the transient event with a binary pseudo-random pattern into spatially encoded frames; a galvanometer scanner temporally shearing the spatially encoded frames; and a CMOS camera receiving the temporally sheared spatially encoded frames, during one exposure time of the camera, for reconstructing the transient event. The method comprises spatial encoding a transient event; temporal shearing resulting spatially encoded frames of the event, spatio-temporal integration, and reconstruction.

Abstract: A transmission electron microscopy system for imaging a sample, comprising: a pulse generator for generating an initial electron pulse towards the sample, the initial electron pulse to be propagated through the sample to obtain a transmitted electron pulse; an encoding device for encoding the transmitted electron pulse according to a predefined pattern to obtain an encoded electron pulse; a shearing device for temporally shearing the encoded electron pulse in a given direction to obtain a given electron pulse; a detector for detecting the given electron pulse to obtain a single image of the sample; and a datacube generator for determining a spatiotemporal datacube from the single image using the predefined pattern, and outputting the spatiotemporal datacube.

Abstract: A transmission electron microscopy system for imaging a sample, comprising: a pulse generator for generating an initial electron pulse towards the sample, the initial electron pulse to be propagated through the sample to obtain a transmitted electron pulse; an encoding device for encoding the transmitted electron pulse according to a predefined pattern to obtain an encoded electron pulse; a shearing device for temporally shearing the encoded electron pulse in a given direction to obtain a given electron pulse; a detector for detecting the given electron pulse to obtain a single image of the sample; and a datacube generator for determining a spatiotemporal datacube from the single image using the predefined pattern, and outputting the spatiotemporal datacube.