Patents by Inventor Xianglin JI

Xianglin JI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240093276
    Abstract: The present invention provides a platform for large-scale profiling of post-transcriptional molecular targets including microRNAs (miRNAs) and methylated messenger RNAs (such as m6A mRNAs) with subcellular spatial resolution in a tissue-wide scale. The present platform is capable of high-throughput isolation of intracellular molecules by contacting an array of functionalized nanoprobes with a target tissue sample for capturing the molecular targets, and the isolated molecular targets are in-situ analysed. The present invention also provides a spectrum barcoding system and related method for digitally quantifying the isolated molecular targets on the nanoprobes and mapping with an imprint of the tissue sample to provide a single-cell spatial coordinate and expression pattern of each of the molecular targets corresponding to different sub-regions of the tissue sample.
    Type: Application
    Filed: September 14, 2022
    Publication date: March 21, 2024
    Inventors: Peng SHI, Xianglin JI
  • Publication number: 20230349010
    Abstract: Disclosed herein are methods of detecting viruses and methods of making a diagnosis of viral infection, by using RNA and DNA probes. According to some embodiments of the present disclosure, the method is useful in detecting and diagnosing SARS-CoV-2 infection. Accordingly, also disclosed herein are a kit for detecting SARS-CoV-2.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 2, 2023
    Inventors: Peng SHI, Zixun WANG, Xi ZHAO, Xianglin JI