Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.

Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.

Abstract: Provided is a cab isolation system for a locomotive is provided including a cab having a front and a rear. The cab isolation system further includes a pivot located generally near the rear of the cab and at least one spring generally located near the front of the cab. In another embodiment, dampers may further be provided and generally located near the front of the cab. In another embodiment, lateral links may further be provided and generally located near the front of the cab. This system may include any of the above elements, alone or in combination, to provide for a cab isolation system for isolating a locomotive cab from engine generated structure borne noise and vibration, while lower frequency track induced motions are not magnified.

Abstract: Provided is a cab isolation system for a locomotive is provided including a cab having a front and a rear. The cab isolation system further includes a pivot located generally near the rear of the cab and at least one spring generally located near the front of the cab. In another embodiment, dampers may further be provided and generally located near the front of the cab. In another embodiment, lateral links may further be provided and generally located near the front of the cab. This system may include any of the above elements, alone or in combination, to provide for a cab isolation system for isolating a locomotive cab from engine generated structure borne noise and vibration, while lower frequency track induced motions are not magnified.

Abstract: Provided is a cab isolation system for a locomotive is provided including a cab having a front and a rear. The cab isolation system further includes a pivot located generally near the rear of the cab and at least one spring generally located near the front of the cab. In another embodiment, dampers may further be provided and generally located near the front of the cab. In another embodiment, lateral links may further be provided and generally located near the front of the cab. This system may include any of the above elements, alone or in combination, to provide for a cab isolation system for isolating a locomotive cab from engine generated structure borne noise and vibration, while lower frequency track induced motions are not magnified.

Abstract: Provided is a cab isolation system for a locomotive is provided including a cab having a front and a rear. The cab isolation system further includes a pivot located generally near the rear of the cab and at least one spring generally located near the front of the cab. In another embodiment, dampers may further be provided and generally located near the front of the cab. In another embodiment, lateral links may further be provided and generally located near the front of the cab. This system may include any of the above elements, alone or in combination, to provide for a cab isolation system for isolating a locomotive cab from engine generated structure borne noise and vibration, while lower frequency track induced motions are not magnified.