Patents by Inventor Xiangmin Yang

Xiangmin Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human-mouse chimeric anti-CD147 antibody with non-fucosylated glycosylation
    Patent number: 9963506
    Abstract: The present disclosure relates to a nucleotide sequence comprising the sequence of SEQ ID NO: 5, and/or sequence of SEQ ID NO: 6, vector and host cell line comprising the nucleotide. The present disclosure also relates to an antibody that binds to extracellular region of human CD147, wherein the antibody comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO: 2, and/or a light chain variable region having the amino acid sequence of SEQ ID NO: 1, and the antibody contains a glycoform lacking both fucose residues and xylose residues, pharmaceutical composition comprising the antibody or fragment thereof, the method of producing the antibody or fragment thereof, and use of the pharmaceutical composition in treatment of CD147 expression-related diseases.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: May 8, 2018
    Assignee: FOURTH MILITARY MEDICAL UNIVERSITY
    Inventors: Zhinan Chen, Zheng Zhang, Yang Zhang, Fei Feng, Muren Huhe, Xiangmin Yang
  • HUMAN-MOUSE CHIMERIC ANTI-CD147 ANTIBODY WITH NON-FUCOSYLATED GLYCOSYLATION
    Publication number: 20170101469
    Abstract: The present disclosure relates to a nucleotide sequence comprising the sequence of SEQ ID NO: 5, and/or sequence of SEQ ID NO: 6, vector and host cell line comprising the nucleotide. The present disclosure also relates to an antibody that binds to extracellular region of human CD147, wherein the antibody comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO: 2, and/or a light chain variable region having the amino acid sequence of SEQ ID NO: 1, and the antibody contains a glycoform lacking both fucose residues and xylose residues, pharmaceutical composition comprising the antibody or fragment thereof, the method of producing the antibody or fragment thereof, and use of the pharmaceutical composition in treatment of CD147 expression-related diseases.
    Type: Application
    Filed: October 7, 2015
    Publication date: April 13, 2017
    Inventors: Zhinan Chen, Zheng Zhang, Yang Zhang, Fei Feng, Muren Huhe, Xiangmin Yang
  • Crystal structure of CD147 extracellular region and use thereof
    Patent number: 8338573
    Abstract: A crystal, a preparation method and 3D structure of CD147 extracellular region are provided. Such 3D structure is useful in the determination of the active site of CD147 extracellular region by computer modeling or molecular docking method. The crystal and/or 3D structure are useful in a structure-based drug design and the selection of an antibody, a ligand or an interacting molecule of CD 147 extracellular region.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: December 25, 2012
    Assignee: Zhinan Chen
    Inventors: Zhinan Chen, Ping Zhu, Xiaoling Yu, Bin Yang, Xiangmin Yang, Zheng Zhang
  • CRYSTAL STRUCTURE OF CD147 EXTRACELLULAR REGION AND USE THEREOF
    Publication number: 20100248974
    Abstract: A crystal, a preparation method and 3D structure of CD147 extracellular region are provided. Such 3D structure is useful in the determination of the active site of CD147 extracellular region by computer modeling or molecular docking method. The crystal and/or 3D structure are useful in a structure-based drug design and the selection of an antibody, a ligand or an interacting molecule of CD 147 extracellular region.
    Type: Application
    Filed: October 24, 2007
    Publication date: September 30, 2010
    Inventors: Zhinan Chen, Ping Zhu, Xiaoling Yu, Bin Yang, Xiangmin Yang, Zheng Zhang