Patents by Inventor Xiangming Gao
Xiangming Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10704103Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of, e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: GrantFiled: November 8, 2018Date of Patent: July 7, 2020Assignee: Hill's Pet Nutrition, Inc.Inventors: Samer Waleed Khedheyer Al-Murrani, Xiangming Gao
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Patent number: 10704102Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of, e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: GrantFiled: November 8, 2018Date of Patent: July 7, 2020Assignee: Hill's Pet Nutrition, Inc.Inventors: Samer Waleed Khedheyer Al-Murrani, Xiangming Gao
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Publication number: 20190078163Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of, e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: ApplicationFiled: November 8, 2018Publication date: March 14, 2019Applicant: Hill's Pet Nutrition, Inc.Inventors: Samer Waleed Khedheyer AL-MURRANI, Xiangming GAO
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Publication number: 20190071728Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of, e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: ApplicationFiled: November 8, 2018Publication date: March 7, 2019Applicant: Hill's Pet Nutrition, Inc.Inventors: Samer Waleed Khedheyer AL-MURRANI, Xiangming GAO
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Patent number: 10144969Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: GrantFiled: June 14, 2012Date of Patent: December 4, 2018Assignee: Colgate-Palmolive CompanyInventor: Xiangming Gao
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Publication number: 20170318837Abstract: The current invention relates to methods of reducing hyperthyroidism in an animal by feeding the animal with a diet including vitamin K. The vitamin K is in an amount effective to reduce factors such as creatinine, triiodothyronine (T3), and thyroid stimulating hormone (TSH). The current invention also relates to pet food composition that include effective amount of vitamin K to reduce the circulating levels of creatinine, T3 and TSH. In addition, the methods of making such a food composition are also disclosed.Type: ApplicationFiled: December 17, 2014Publication date: November 9, 2017Applicant: Hill's Pet Nutrition, Inc.Inventors: Dennis JEWELL, Xiangming GAO
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Patent number: 9629382Abstract: The present invention provides compositions and methods for treatment of abnormal conditions in a subject, wherein the abnormal condition affects the musculoskeletal joints of the subject.Type: GrantFiled: July 20, 2009Date of Patent: April 25, 2017Assignee: Hill's Pet Nutrition, Inc.Inventors: Ryan Michael Yamka, Nolan Zebulon Frantz, Xiangming Gao, Samer Al-Murrani
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Patent number: 9476868Abstract: The present invention provides methods for: diagnosing of, devising and monitoring a treatment plan for, and monitoring the status of a kidney disorder characterized by an abnormal loss of renal function, renal failure, reduced glomerular filtration rate or glomerulonephritis, in a canine, wherein the kidney disorder is detectable by utilizing at least one relevant biomarker isolated and measured from a biological test sample taken from such canine. The invention additionally relates to compositions, reagents and kits for carrying out the specified methods.Type: GrantFiled: December 23, 2010Date of Patent: October 25, 2016Assignee: Hill's Pet Nutrition, Inc.Inventors: Samer Al-Murrani, Sukhaswami Malladi, Xiangming Gao
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Patent number: 9255296Abstract: The present invention provides a method of diagnosing the existence of a kidney disorder in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of lumican; collagen alpha 1 (111) chain, variant 12; decorin; secreted frizzled-related protein 2; retinol binding protein 5; MMP-2; MMP-7; and MMP-19, in a biological sample from the feline, wherein differences in expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal animal indicate the existence of a kidney disorder; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: GrantFiled: February 24, 2011Date of Patent: February 9, 2016Assignee: HILL'S PET NUTRITION, INC.Inventors: Samer Waleed Al-Murrani, Xiangming Gao, Sukhaswami Malladi
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Publication number: 20150118155Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: ApplicationFiled: June 14, 2012Publication date: April 30, 2015Applicant: Hill's Pet Nutrition, Inc.Inventors: Samer Al-Murrani, Xiangming Gao
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Publication number: 20130344196Abstract: The present invention provides a method of diagnosing the existence of a kidney disorder in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of lumican; collagen alpha 1 (111) chain, variant 12; decorin; secreted frizzled-related protein 2; retinol binding protein 5; MMP-2; MMP-7; and MMP-19, in a biological sample from the feline, wherein differences in expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal animal indicate the existence of a kidney disorder; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: ApplicationFiled: February 24, 2011Publication date: December 26, 2013Applicant: HILL'S PET NUTRITION, INC.Inventors: Samer Waleed Al-Murrani, Xiangming Gao, Sukhaswami Malladi
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Publication number: 20130059012Abstract: The invention relates to methods of diagnosis, control and prophylaxis of inflammation and mitigation of inflammatory conditions, particularly arthritis and joint pain, in felines, comprising measuring particular inflammatory biomarkers. The invention further provides a method to treat or control inflammation comprising administering a diet comprising increased levels of one or more of DHA, EPA, methionine, manganese, vitamin C, vitamin E, and/or L-carnitine.Type: ApplicationFiled: May 9, 2011Publication date: March 7, 2013Applicant: HILL'S PET NUTRITION, INCInventors: Samer Al-Murrani, Xiangming Gao, Junyu Lee, Sukhaswami Malladi, Nolan Zebulon Frantz
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Publication number: 20120283129Abstract: The present invention provides methods for: diagnosing of, devising and monitoring a treatment plan for, and monitoring the status of a kidney disorder characterized by an abnormal loss of renal function, renal failure, reduced glomerular filtration rate or glomerulonephritis, in a canine, wherein the kidney disorder is detectable by utilizing at least one relevant biomarker isolated and measured from a biological test sample taken from such canine. The invention additionally relates to compositions, reagents and kits for carrying out the specified methods.Type: ApplicationFiled: December 23, 2010Publication date: November 8, 2012Applicant: HILL'S PET NUTRITION, INCInventors: Samer Al-Murrani, Sukhaswami Malladi, Xiangming Gao
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Publication number: 20110189303Abstract: The present invention relates to methods for enhancing the quality of life of a senior or super senior animal by feeding the animal a composition comprising at least one omega-3 polyunsaturated fatty acid and various combinations of amino acids, minerals, and antioxidants in amounts effective to enhance alertness, improve vitality, protect cartilage, maintain muscle mass, enhance digestibility, and improve skin and pelage quality. Beneficial changes in expression of genes associated with several biological pathways may be induced in an animal by feeding it said composition and are consistent with an enhancement in the quality of life of said animal.Type: ApplicationFiled: July 20, 2009Publication date: August 4, 2011Applicant: Hill's Pet Nutrition, Inc.Inventors: Ryan Michael Yamka, Nolan Zebulon Frantz, Xiangming Gao, Kim Friesen
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Publication number: 20110183006Abstract: The present invention provides compositions and methods for treatment of abnormal conditions in a subject, wherein the abnormal condition affects the musculoskeletal joints of the subject.Type: ApplicationFiled: July 20, 2009Publication date: July 28, 2011Applicant: Hills Pet Nutrition, Inc.Inventors: Ryan Michael Yamka, Nolan Zebulon Frantz, Xiangming Gao, Samer Al-Murrani
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Publication number: 20110178005Abstract: The invention encompasses compositions and methods for treating disorders and diseases associated with overweight. The application also encompasses genes differentially expressed in animals and particularly to genes differentially expressed in overweight animals compared to lean animals.Type: ApplicationFiled: July 20, 2009Publication date: July 21, 2011Applicant: HILL'S PET NUTRITION, INC.Inventors: Ryan Michael Yamka, Nolan Zebulon Frantz, Xiangming Gao, Samer Al-Murrani
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Publication number: 20100137404Abstract: Compositions and methods for regulating gene expression in a growing animal are disclosed.Type: ApplicationFiled: February 22, 2008Publication date: June 3, 2010Applicant: HILL'S PET NUTRITION, INC.Inventors: Ryan Michael Yamka, Kim Gene Friesen, Steven Curtis Zicker, Nolan Zebulon Frantz, Xiangming Gao
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Publication number: 20090217398Abstract: A combination comprising two or more polynucleotides that are differentially expressed in fat animals compared to lean animals or two or more proteins produced by the expression of such polynucleotides is disclosed. The combination and probes based upon the combination are used for formulating a prognosis that an animal is likely to become fat, developing a diagnosis that an animal is fat, screening substances to determine if they are useful for modulating the amount of adipose tissue on an animal, and detecting the differential expression of one or more genes differentially expressed in fat animals compared to lean animals in a sample. Methods for using class predictor gene profiles to identify fat and lean animals are also disclosed.Type: ApplicationFiled: March 2, 2007Publication date: August 27, 2009Applicant: Hill's Pet Nutrition, Inc.Inventors: Samer Al Murrani, Kim Gene Friesen, Ryan Michael Yamka, William D. Schoenherr, Sukhaswami Malladi, Xiangming Gao