Abstract: Disclosed are a display apparatus and a method for displaying a user interface. In response to a preset instruction, the display apparatus acquires local images to generate a local video stream, plays a local video picture, and displays a graphic element for identifying a preset expected position in a floating layer above the local video picture. When the moving target exists in the local video picture and an offset of a target position of the moving target in the local video picture relative to the expected position is greater than a preset threshold value, a prompt control for guiding the moving target to move to the expected position is presented in the floating layer above the local video picture according to the offset of the target position relative to the expected position.

Abstract: In various embodiments, drug delivery vehicles that contain one or more metal-based therapeutic agents are provided. In certain embodiments, the drug delivery vehicle comprises: a silica nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication with the outside surface of the nanoparticle; a metal-based (e.g., platinum-based) chemotherapeutic drug disposed on the surface of the nanoparticle and/or within the one or more cavities of the nanoparticle where the drug comprises a cationic, metal-based drug; and a lipid bilayer disposed on the surface of the nanoparticle where the lipid bilayer fully encapsulates and seals the nanoparticle.

Abstract: A large gear involute artifact assembled with mandrel used as physical datum of precision traceability and measurement transmission for large gear involute is proposed. The artifact comprises a large gear involute artifact stripe, a mandrel, a backing plate, a counterweight shaft, an adjustable counterweight ring, the adjustable screws of counterweight, the connecting screws for backing plate, the connecting screws for artifact and an eccentric multi-ball bearing. The structure and the rolled length of the large gear involute artifact assembled with mandrel fit the basic requirements of class-1 accuracy in the national standard of gear involute artifact GB/T 6467-2010 in China. It has advantages of long rolled length, adjustable center of mass, uniform datum, compact structure, and portability. It adopts lightweight design, which can be installed and transported by one person manually, and is suitable for the structural design of large gear involute artifact with base-circle diameter greater than 500 mm.

Abstract: In various embodiments, methods of treating a cancer are provided. In certain embodiments, the methods comprise administering to a mammal in need thereof i) one or more checkpoint inhibitor(s); and ii) one or more camptothecin analogs, and, optionally, or one or more autophagy inhibitors wherein said camptothecin analog, and one or more autophagy inhibitors, when present, are provided inside a delivery vehicle where said delivery vehicle comprises: a nanoparticle comprising one or more cavities disposed within said nanoparticle and an outside surface where said one or more cavities are in fluid communication the outside surface of said nanoparticle; said one or more camptothecin analog, one or more autophagy inhibitors, when present, are disposed within said one or more cavities; and a lipid bilayer is disposed on the surface of said nanoparticle where said lipid bilayer fully encapsulates the nanoparticle.

Abstract: In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

Abstract: A generating device based on friction drive for gear involute artifact with long-rolled path length by rolling method is proposes. The device includes a roller component, rail component and friction-driven component, wherein the roller component consists of a gear involute artifact with long rolled length, a mandrel, a multi-ball bearing for gear involute artifact, the base-circle plates, the parallel sleeves, a multi-ball bearing, the plain washers, the cross washers, and the locking nuts; the rail component consists of a foundation, a location baffle for base-circle plates, rails, the baffles, a location baffle for rail, copper washers, the connecting screws and the set screws of the rail; and the friction-driven component consists of a friction block, a motorized linear sliding table, a vertical sliding table, a vertical foundation and an adapter. It has good market application prospect and popularization value.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: The present invention provides a process for metallurgy and separating a rare earth concentrate using a combination method, the process including: treating the rare earth concentrate containing bastnaesite by using a method including roasting under an atmosphere, leaching with hydrochloric acids, and roasting with a sulfuric acid, wherein stepping acid leaching with low-concentration hydrochloric acids is controlled during the leaching with the hydrochloric acids so as to obtain a rare earth solution with a high concentration (150-250 g/L REO), such that a leaching rate of Ce reaches 60% or more, and the content of F? in a leaching liquor is reduced by aging; and rare earth is further recovered from a leach residue by roasting with the sulfuric acid and leaching with water, and the total yield of the rare earth reaches 95% or more.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.

Abstract: A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.