Patents by Inventor Xiangtian Long

Xiangtian Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate
    Patent number: 10358417
    Abstract: The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting to obtain reacting to obtain reacting to obtain and reacting to obtain In the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: July 23, 2019
    Assignee: Chen-Stone (Guangzhou) Co., Ltd.
    Inventors: Yingjie Lai, Dabing Ye, Fengrui Lang, Xiangtian Long
  • METHOD FOR PREPARING EFFICIENTLY SYNTHETIC SITAFLOXACIN INTERMEDIATE (7S)-5-AZASPIRO[2.4]HEPTANE-7-YL TERT-BUTYL CARBAMATE
    Publication number: 20180370914
    Abstract: The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting to obtain reacting to obtain reacting to obtain and reacting to obtain In the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.
    Type: Application
    Filed: April 25, 2017
    Publication date: December 27, 2018
    Inventors: Yingjie Lai, Dabing Ye, Fengrui Lang, Xiangtian Long
  • Methods for synthesizing molybdopterin precursor Z derivatives
    Patent number: 9260462
    Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: February 16, 2016
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Xiangtian Long, Danmei Dai, Andreas Brunner, Derek Kevin Watt, Keith Clinch, Sylvia Myrna Baars, Rachel Anne Dixon, Gillian Mary Little, Cyrille Abel Sébastien Landreau, Nicolas Georges Rene Proisy
  • Methods for synthesizing molybdopterin precursor Z derivatives
    Publication number: 20140323726
    Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
    Type: Application
    Filed: February 17, 2012
    Publication date: October 30, 2014
    Applicant: ALEXION PHARMA INTERNATIONAL SÀRL
    Inventors: Xiangtian Long, Danmei Dai, Andreas Brunner, Derek Kevin Watt, Keith Clinch, Sylvia Myrna Baars, Rachel Anne Dixon, Gillian Mary Little, Cyrille Abel Sébastien Landreau, Nicolas Georges Rene Proisy
  • Methods for Synthesizing Molybdopterin Precursor Z Derivatives
    Publication number: 20140303367
    Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
    Type: Application
    Filed: March 7, 2014
    Publication date: October 9, 2014
    Applicant: Alexion Pharma International Sàrl
    Inventors: Xiangtian Long, Danmei Dai, Andreas Brunner, Derek Kevin Watt, Keith Clinch, Sylvia Myrna Baars, Rachel Anne Dixon, Gillian Mary Little, Cyrille Abel Sébastien Landreau, Nicolas George Rene Proisy