Patents by Inventor Xiangui HUANG

Xiangui HUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof
    Publication number: 20230348467
    Abstract: The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in particular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.
    Type: Application
    Filed: January 12, 2021
    Publication date: November 2, 2023
    Applicants: Zhejiang Hisun Pharmaceutical Co., Ltd., Hisun AccuRay Therapeutics Co., Ltd.
    Inventors: Xiangui Huang, Yanghui Guo, Zongxing Qiu, Pingyan Bie, Weiwei Liao, Qingyan Yan, Weichao Shen, Hai Cao, Qingna Xing, Xin Wang, Qi Cao, Lichen Meng, Nuoyi Wu, Wenpeng Li, Cheng Ye, Taishan Hu, Lei Chen
  • SALT OF TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Publication number: 20230242522
    Abstract: The present invention relates to a pharmaceutically acceptable salt of (S)-2-(6-fluorobenzo[d]oxazol-2-yl)-6-methoxy-5-((5-methoxypyridin-2-yl))methoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, a preparation method therefor, a pharmaceutical composition comprising the pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as an angiotensin II type-2 receptor antagonist.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 3, 2023
    Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD., SHANGHAI ARYL PHARMTECH CO., LTD.
    Inventors: Yanghui GUO, Lichen MENG, Xiangui HUANG, Weiwei LIAO, Yongxiang GONG, Daiwang XU, Taishan HU, Lei CHEN
  • Tetrahydroisoquinoline derivative, preparation method therefor and use thereof
    Patent number: 11384097
    Abstract: Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: July 12, 2022
    Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Yanghui Guo, Xiangui Huang, Weiwei Liao, Lichen Meng, Taishan Hu, Lei Chen, Guoping Jiang
  • TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20210277021
    Abstract: Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.
    Type: Application
    Filed: June 18, 2019
    Publication date: September 9, 2021
    Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    Inventors: Yanghui GUO, Xiangui HUANG, Weiwei LIAO, Lichen MENG, Taishan HU, Lei CHEN, Guoping JIANG