Patents by Inventor Xiangxian Hong

Xiangxian Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing fluticasone furoate
    Patent number: 8969547
    Abstract: Method for preparing fluticasone furoate (6?,9?-difluoro-11?-hydroxy-16?-methyl-17?-[(2-furoyl)oxy]-3-oxo-androsta-1,4-diene-17?-carbothioic acid S-fluoromethyl ester) by directly subjecting a compound of Formula III and a complex of a fluoromethylating reagent in presence of an organic base to a replacement reaction to obtain the target compound. Generation of impurities in a process via Compound IV is avoided; the method is simple with mild reaction conditions, suitable for industrial production, and yields products with purity of 98% by HPLC.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 3, 2015
    Assignees: Zhejiang Tiantai Aurisco Pharmaceuticals Co. Ltd., Shanghai Aurisco Industry Co., Ltd.
    Inventors: Dingjun Chu, Haijie Ji, Xiangxian Hong
  • METHOD FOR PREPARING FLUTICASONE FUROATE
    Publication number: 20130274461
    Abstract: Method for preparing fluticasone furoate (6?,9?-difluoro-11?-hydroxy-16?-methyl-17?-[(2-furoyl)oxy]-3-oxo-androsta-1,4-diene-17?-carbothioic acid S-fluoromethyl ester) by directly subjecting a compound of Formula III and a complex of a fluoromethylating reagent in presence of an organic base to a replacement reaction to obtain the target compound. Generation of impurities in a process via Compound IV is avoided; the method is simple with mild reaction conditions, suitable for industrial production, and yields products with purity of 98% by HPLC.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Inventors: Dingjun CHU, Haijie Ji, Xiangxian Hong