Abstract: A flat spot-proof tire, and a vehicle. The flat spot-proof tire comprises a tread, a cap ply, a belt ply and a carcass. The rubber hardness of the tread is 68-78 Shore A. The cap ply is formed by nylon cords having linear density of 90-140 pieces per 100 mm. The belt ply is formed by steel cords, which comprise HT steel wires and/or SHT steel wires. The carcass is formed by polyester cords having linear density of 100-120 pieces per 100 mm. The flat spot-proof tire and the vehicle use suitable industrial rubber and polyester fiber material, have a specific size design and undergo an optimized inflation process after vulcanization such that the long-term flat spot effects of the tire can be mitigated, and the jitter of the vehicle during high-speed traveling can be reduced.