Patents by Inventor XiangYu Kong

XiangYu Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for methanol independent induction from methanol inducible promoters in
    Patent number: 8236528
    Abstract: A method for producing a polypeptide in a methylotrophic yeast host cell is described, where expression of the polypeptide is controlled by a methanol inducible promoter, including: i) expression of a positive regulator from a non-native promoter, the positive regulator activating transcription from the methanol inducible promoter, and ii) no addition of methanol.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: August 7, 2012
    Assignee: Novozymes A/S
    Inventors: Shinobu Takagi, Noriko Tsutsumi, Yuji Terui, XiangYu Kong
  • METHOD FOR METHANOL INDEPENDENT INDUCTION FROM METHANOL INDUCIBLE PROMOTERS IN PICHIA
    Publication number: 20120142053
    Abstract: A method for producing a polypeptide in a methylotrophic yeast host cell is described, where expression of the polypeptide is controlled by a methanol inducible promoter, including: i) expression of a positive regulator from a non-native promoter, the positive regulator activating transcription from the methanol inducible promoter, and ii) no addition of methanol.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 7, 2012
    Applicant: NOVOZYMES A/S
    Inventors: Noriko Tsutsumi, Yuji Terui, Shinobu Takagi, XiangYu Kong
  • Method for methanol independent induction from methanol inducible promoters in
    Patent number: 8143023
    Abstract: A method for producing a polypeptide in a methylotrophic yeast host cell is described, where expression of the polypeptide is controlled by a methanol inducible promoter, including: i) expression of a positive regulator from a non-native promoter, the positive regulator activating transcription from the methanol inducible promoter, and ii) no addition of methanol.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: March 27, 2012
    Assignee: Novozymes A/S
    Inventors: Shinobu Takagi, Noriko Tsutsumi, Yuji Terui, XiangYu Kong
  • Expression of Genes from Gram Negative Bacteria in Fungi
    Publication number: 20100261259
    Abstract: The present invention provides a method for the recombinant expression of polypeptides originating from gram negative bacteria, in a fungal host suitable for industrial production. In a first aspect the present invention relates to a method for recombinant expression of a polypeptide from a gram negative bacterium in a fungal host cell, comprising the steps: i) providing a nucleic acid sequence encoding the polypeptide, said nucleic acid sequence comprising a first nucleic acid sequence encoding a fungal signal peptide and a second nucleic acid sequence encoding the polypeptide, having at least one modified codon, wherein the modification does not change the amino acid encoded by said codon and the nucleic acid sequence of said codon is different compared to the corresponding codon in the wild type nucleic acid sequence present in the said gram negative bacterium; ii) expressing the modified nucleic acid sequence in the fungal host.
    Type: Application
    Filed: August 3, 2007
    Publication date: October 14, 2010
    Applicant: Novozymes A/S
    Inventors: Tomoko Matsui, Pia Francke Johannesen, Shinobu Takagi, Thomas Agersten Poulsen, Noriko Tsutsumi, Zheng Liu, XiangYu Kong
  • Method for methanol independent induction from methanol inducible promoters in Pichia
    Publication number: 20090311749
    Abstract: The present invention relates to a method for producing a polypeptide in a methylotrophic yeast host cell, wherein expression of the polypeptide is controlled by a methanol inducible promoter, comprising: i) expression of a positive regulator from a non-native promoter, said positive regulator activating transcription from the methanol inducible promoter, and ii) no addition of methanol.
    Type: Application
    Filed: January 25, 2008
    Publication date: December 17, 2009
    Applicant: Novozymes A/S
    Inventors: Shinobu Takagi, Noriko Tsutsumi, Yuji Terui, XiangYu Kong