Abstract: The present application relates to the technical field of chimeric antigen receptor T cell immunotherapy (CART), and in particular to a transgenic immune cell, and a construction method therefor and a use thereof. The present application provides a gene containing three coding regions, a recombinant nucleic acid containing the gene, a biological material, and a transgenic immune effector cell, wherein three functional proteins can be coded, and the expression of the three proteins enables an immune effector cell to have multiple functions, thereby reducing the inhibition effect of a solid tumor microenvironment on the immune effector cell, prolonging the time of the killing effect of the immune effector cell, and improving the anti-tumor efficacy of the immune effector cell.

Abstract: Double-coated high-nickel lithium-ion cathode material, including a cathode material substrate, a first coating layer coated on a surface of the cathode material substrate, and a second coating layer coated on a surface of the first coating layer; wherein the first coating layer and the second coating layer are prepared by successively coating the cathode material substrate with a metal oxide and a boron-containing compound. The high-nickel cathode material for lithium-ion batteries of the present invention has a stable structure and interface, is relatively stable in the air, and is convenient for large-scale production. The prepared battery has low gas production and high safety.

Abstract: Disclosed is a debris flow anti-collision device with a high-speed water curtain for a mountain bridge. A pressurizer is fixedly installed in a groove of a base; the pressurizer is communicated with high-speed water curtain spray pipe components, and each high-speed water curtain spray pipe component penetrates through a side wall of the base and communicates with an outside; the base rotates with several groups of spoilers, an outer side of the base is fixedly provided with several groups of energy dissipation components, and a connecting bar is detachably connected between each group of energy dissipation components and the base; rear ends of the base are detachably connected with baffles; and the pressurizer is communicated with a water storage tank.

Abstract: Disclosed is a debris flow anti-collision device with a high-speed water curtain for a mountain bridge. A pressurizer is fixedly installed in a groove of a base; the pressurizer is communicated with high-speed water curtain spray pipe components, and each high-speed water curtain spray pipe component penetrates through a side wall of the base and communicates with an outside; the base rotates with several groups of spoilers, an outer side of the base is fixedly provided with several groups of energy dissipation components, and a connecting bar is detachably connected between each group of energy dissipation components and the base; rear ends of the base are detachably connected with baffles; and the pressurizer is communicated with a water storage tank.

Abstract: Provided is an antibody or antigen-binding fragment thereof that can specifically recognize CD22. The antibody contains a CDR sequence selected from at least one of the following or an amino acid sequence at least 95% identical thereto: a heavy-chain variable region CDR sequence: SEQ ID NOs: 1-15, and a light-chain variable region CDR sequence as shown in SEQ IN NOs: 16-30. The antibody can specifically recognize CD22 and has high affinity to CD22.

Abstract: The present disclosure provides a communication chip, which is applied to a terminal device and includes a system control module, a radio frequency signal processing module, a first baseband processing module, and a second baseband processing module, where the system control module is respectively connected to the radio frequency signal processing module, the first baseband processing module and the second baseband processing module; the radio frequency signal processing module is further respectively connected to the first baseband processing module and the second baseband processing module.

Abstract: Provided is a T lymphocyte. The T lymphocyte co-expresses a fusion protein and a chimeric antigen receptor, and the chimeric antigen receptor identifies a tumor antigen, herein the chimeric antigen receptor includes: an extracellular region; a transmembrane region, herein the transmembrane region is connected to the extracellular region, and embedded into a cell membrane of a transgenic lymphocyte; and an intracellular region, herein the intracellular region is connected to the transmembrane region, and the intracellular region includes an immune co-stimulatory molecule intracellular segment. The fusion protein includes: an immune checkpoint single-chain antibody and a T cell activation molecule.

Abstract: Provided is an antibody, which is capable of specifically binding to a B-cell maturation antigen (BCMA). The provided BCMA antibody is capable of specifically binding to an extracellular fragment of the BCMA and has excellent affinity and specificity; and the antibody is a functional antibody and has the activity blocking binding of the BCMA with its ligand APRIL. Immune cells constructed based on the antibody has an excellent specific killing function for a BCMA-positive tumor cell.