Patents by Inventor Xianjun You

Xianjun You has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
    Publication number: 20220177435
    Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 9, 2022
    Inventors: Vikram S. Kumar, David P. Hesson, Ping Huang, Mo Jia, Xianjun You
  • Compositions and methods for inhibiting dihydroorotate dehydrogenase
    Patent number: 11230528
    Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: January 25, 2022
    Inventors: Vikram S. Kumar, David P. Hesson, Ping Huang, Mo Jia, Xianjun You
  • STABLE POLYMORPHIC COMPOSITIONS OF BREQUINAR SODIUM AND METHODS OF USE AND MANUFACTURE THEREOF
    Publication number: 20210300873
    Abstract: The invention provides compositions containing a stable crystalline form of brequinar and methods of making such composition. The invention also provides methods of using such compositions to treat a condition in a subject.
    Type: Application
    Filed: March 19, 2021
    Publication date: September 30, 2021
    Inventors: Abdolsamad Tadayon, Ping Huang, Chaoyi Deng, Jinsuo Yang, Siyi Jiang, Qingqing Lu, Lin Cui, Mo Jia, Xianjun You, David P. Hesson
  • STABLE POLYMORPHIC COMPOSITIONS OF BREQUINAR SODIUM AND METHODS OF USE AND MANUFACTURE THEREOF
    Publication number: 20210292280
    Abstract: The invention provides compositions containing a stable crystalline form of brequinar and methods of making such composition. The invention also provides methods of using such compositions to treat a condition in a subject.
    Type: Application
    Filed: March 19, 2021
    Publication date: September 23, 2021
    Inventors: Abdolsamad Tadayon, Ping Huang, Chaoyi Deng, Jinsuo Yang, Qingqing Lu, Lin Cui, Mo Jia, Xianjun You, David P. Hesson, Siyi Jiang
  • COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
    Publication number: 20210087146
    Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
    Type: Application
    Filed: December 4, 2020
    Publication date: March 25, 2021
    Inventors: Vikram S. Kumar, David P. Hesson, Ping Huang, Mo Jia, Xianjun You
  • Compositions and methods for inhibiting dihydroorotate dehydrogenase
    Patent number: 10889548
    Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: January 12, 2021
    Assignee: Clear Creek Bio, Inc.
    Inventors: Vikram S. Kumar, David P. Hesson, Ping Huang, Mo Jia, Xianjun You
  • COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
    Publication number: 20190292154
    Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 26, 2019
    Inventors: Vikram S. Kumar, David P. Hesson, Ping Huang, Mo Jia, Xianjun You