Abstract: Disclosed are a pyrrolopyrazole derivative, a preparation method therefor, and the medical use thereof. In particular, disclosed are a novel class of pyrrolopyrazole derivatives represented by general formula (I), a preparation method therefor, and the use of the pyrrolopyrazole derivatives or pharmaceutical compositions containing the pyrrolopyrazole derivatives in biomedicine as therapeutic agents, particularly as gastric acid secretion inhibitors and potassium ion competitive acid blochers (P-CABs). The definitions of various substituent (R1, R2, R3, R4) and the group (X) in general formula (I) are the same as the definitions in the description.

Abstract: The present disclosure provides a 3-phenoxybenzoic acid-glucuronic acid conjugate, and a preparation method and use thereof, and belongs to the technical field of pesticide detection. Compared with 3-phenoxybenzoic acid, the 3-phenoxybenzoic acid-glucuronic acid conjugate provided by the present disclosure features structural stability, high specificity, long limit of detection, and high content in urine, and can better serve as a marker that identifies whether an organism is killed due to pyrethroid pesticide poisoning. Namely, the 3-phenoxybenzoic acid-glucuronic acid conjugate can detect whether a toxicant (pyrethroid pesticides) is taken antemortem or exposed postmortem, and has an excellent application prospect in pyrethroid pesticide detection. The present disclosure provides a preparation method of a 3-phenoxybenzoic acid-glucuronic acid conjugate.

Abstract: A novel type of pyrrolopyrazole derivatives shown in general formula (I), a preparation method thereof and application thereof or a pharmaceutical composition containing same as a therapeutic agent, particularly as a gastric acid secretion inhibitor and a potassium-competitive acid blocker (P-CABs) in biomedicine.

Abstract: Disclosed are a pyrrolopyrazole derivative, a preparation method therefor, and the medical use thereof. In particular, disclosed are a novel class of pyrrolopyrazole derivatives represented by general formula (I), a preparation method therefor, and the use of the pyrrolopyrazole derivatives or pharmaceutical compositions containing the pyrrolopyrazole derivatives in biomedicine as therapeutic agents, particularly as gastric acid secretion inhibitors and potassium ion competitive acid blochers (P-CABs). The definitions of various substituent (R1, R2, R3, R4) and the group (X) in general formula (I) are the same as the definitions in the description.

Abstract: The present invention relates to pyrrolo-pyrazol derivatives, a preparation method thereof and application thereof in medicine, and particularly to a novel category of pyrrolo-pyrazol derinatives respesented by formula (I), a preparation method thereof and a bio-pharmaceutical use thereof or of pharmaceutical compositions containing the same as therapeutic agents, especially as gastric acid secretion inhibitors and potassium-competitive acid blockers (P-CABs). Substituent groups (Ar and R1) in formula(I) are defined identically as in description.

Abstract: The present invention relates to pyrrolo-pyrazol derivatives, a preparation method thereof and application thereof in medicine, and particularly to a novel category of pyrrolo-pyrazol derivatives represented by formula (I), a preparation method thereof and a bio-pharmaceutical use thereof or of pharmaceutical compositions containing the same as therapeutic agents, especially as gastric acid secretion inhibitors and potassium-competitive acid blockers (P-CABs).

Abstract: A class of pyrrolopyrazole derivatives represented by general formula (I), a preparation method thereof, and the applications of said derivatives or of pharmaceutical compositions containing said class of derivatives as therapeutic agents, especially the application as gastric acid secretion inhibitors and potassium ion competitive acid blockers (P-CABs) in biomedicine.