Patents by Inventor Xianliang Xin

Xianliang Xin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS CONTAINING ALGINATE OLIGOSACCHARAIDE DIACID
    Publication number: 20220387477
    Abstract: The invention relates to a pharmaceutical composition containing alginate oligosaccharide diacid with formula (IV) or a pharmaceutically acceptable salt thereof, which can be used for preparing medicaments for treating Alzheimer's disease, Parkinson's disease, inflammation, pain, diabetes or vascular dementia.
    Type: Application
    Filed: October 26, 2020
    Publication date: December 8, 2022
    Inventors: Yingshen Jin, Xianliang Xin, Zhongping Xiao, Zhenqing Zhang, Meiyu Geng
  • COMPOSITION OF MANNURONIC DIACID
    Publication number: 20220356202
    Abstract: The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m? is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.
    Type: Application
    Filed: July 8, 2022
    Publication date: November 10, 2022
    Inventors: Meiyu Geng, Jian Ding, Zhenqing Zhang, Zhongping Xiao, Xiaoguang Du, Xianliang Xin
  • Use of mannuronic diacid composition in treatment of diabetes
    Patent number: 11406652
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 9, 2022
    Assignees: GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Meiyu Geng, Xianliang Xin, Zhenqing Zhang, Jian Ding
  • Use of mannuronic diacid composition in treatment of vascular dementia
    Patent number: 11406651
    Abstract: The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 9, 2022
    Assignees: GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Meiyu Geng, Xianliang Xin, Xiaoguang Du, Zhenqing Zhang, Jian Ding
  • Use of mannuronic diacid composition in treatment of pain
    Patent number: 11406653
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 9, 2022
    Assignees: GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Meiyu Geng, Xianliang Xin, Zhenqing Zhang, Jian Ding
  • Use of mannuronic diacid composition in treatment of inflammation
    Patent number: 11406659
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 9, 2022
    Assignees: GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Meiyu Geng, Xianliang Xin, Zhenqing Zhang, Jian Ding
  • Use of mannuronic diacid composition in treatment of Parkinson's disease
    Patent number: 11406654
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 9, 2022
    Assignees: GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Meiyu Geng, Xianliang Xin, Xiaoguang Du, Zhenqing Zhang, Jian Ding
  • Composition of mannuronic diacid
    Patent number: 11384111
    Abstract: The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m? is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: July 12, 2022
    Assignee: GREEN VALLEY (SHANGHAI) PHARMACEUTICAL CO., LTD. SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
    Inventors: Meiyu Geng, Jian Ding, Zhenqing Zhang, Zhongping Xiao, Xiaoguang Du, Xianliang Xin
  • USE OF MANNURONIC DIACID COMPOSITION IN TREATMENT OF PAIN
    Publication number: 20210361684
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.
    Type: Application
    Filed: June 28, 2019
    Publication date: November 25, 2021
    Inventors: Meiyu Geng, Xianliang Xin, Zhenqing Zhang, Jian Ding
  • USE OF MANNURONIC DIACID COMPOSITION IN TREATMENT OF DIABETES
    Publication number: 20210322449
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.
    Type: Application
    Filed: June 28, 2019
    Publication date: October 21, 2021
    Inventors: Meiyu Geng, Xianliang Xin, Zhenqing Zhang, Jian Ding
  • USE OF MANNURONIC DIACID COMPOSITION IN TREATMENT OF INFLAMMATION
    Publication number: 20210275570
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.
    Type: Application
    Filed: June 28, 2019
    Publication date: September 9, 2021
    Inventors: Meiyu Geng, Xianliang Xin, Zhenqing Zhang, Jian Ding
  • USE OF MANNURONIC DIACID COMPOSITION IN TREATMENT OF VASCULAR DEMENTIA
    Publication number: 20210268006
    Abstract: The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.
    Type: Application
    Filed: June 28, 2019
    Publication date: September 2, 2021
    Inventors: Meiyu Geng, Xianliang Xin, Xiaoguang Du, Zhenqing Zhang, Jian Ding
  • USE OF MANNURONIC DIACID COMPOSITION IN TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20210260089
    Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.
    Type: Application
    Filed: June 28, 2019
    Publication date: August 26, 2021
    Inventors: Meiyu Geng, Xianliang Xin, Xiaoguang Du, Zhenqing Zhang, Jian Ding
  • COMPOSITION OF MANNURONIC DIACID
    Publication number: 20200385417
    Abstract: The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m? is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.
    Type: Application
    Filed: December 27, 2017
    Publication date: December 10, 2020
    Inventors: Meiyu Geng, Jian Ding, Zhenqing Zhang, Zhongping Xiao, Xiaoguang Du, Xianliang Xin
  • ALGINATE OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME
    Publication number: 20190255092
    Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 22, 2019
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun
  • Alginate oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same
    Patent number: 10213456
    Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: February 26, 2019
    Assignee: Ocean University Of China
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun
  • ALGIN OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME
    Publication number: 20170112870
    Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100-120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Application
    Filed: November 14, 2016
    Publication date: April 27, 2017
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun
  • Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same
    Patent number: 9493496
    Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: November 15, 2016
    Assignee: Ocean University Of China
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun
  • ALGIN OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME
    Publication number: 20150105344
    Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Application
    Filed: September 10, 2014
    Publication date: April 16, 2015
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun
  • Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same
    Patent number: 8835403
    Abstract: The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The present invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedures that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2-6 and the temperature of 100-120° C., and pH is adjusted to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative degradation product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: September 16, 2014
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun