Patents by Inventor Xianqing Shi

Xianqing Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20230373955
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Application
    Filed: July 26, 2023
    Publication date: November 23, 2023
    Inventors: Sebastien CAILLE, Kyle QUASDORF, Philipp C. ROOSEN, Xianqing SHI, Andrew COSBIE, Fang WANG, Zufan WU, Archana NEERGUNDA, Bin Peter QUAN, Lianxiu GUAN
  • Synthesis of omecamtiv mecarbil
    Patent number: 11753394
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: September 12, 2023
    Assignee: AMGEN INC.
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp C. Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20210371397
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Application
    Filed: May 19, 2021
    Publication date: December 2, 2021
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp C. Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • Synthesis of omecamtiv mecarbil
    Patent number: 11040956
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 22, 2021
    Assignee: AMGEN INC.
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • SYNTHESIS OF OMECAMTIV MECARBIL
    Publication number: 20200308143
    Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 1, 2020
    Inventors: Sebastien Caille, Kyle Quasdorf, Philipp Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
  • (3,4-dichloro-phenyl)-((S)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes
    Patent number: 9527810
    Abstract: The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates The compounds of formula I and the corresponding hydrates are pharmaceutically active substances.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: December 27, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Michel Adam, Charles Alois Dvorak, Daniel Fishlock, Eric R. Humphreys, Hans Iding, Christophe Pfleger, Pankaj D. Rege, Xianqing Shi, Justin Vitale, Shaoning Wang, Marian Zajac
  • Process for synthesis of amino-methyl tetralin derivatives
    Patent number: 9365494
    Abstract: Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L)??j1; Ru(E)(E?)(L)(D)??j2; wherein m, n, Ar, Y, R1E, E?, D, Z and L are as defined herein.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 14, 2016
    Assignee: Roche Palo Alto LLC
    Inventors: Kieran Durkin, Lawrence Emerson Fisher, Arthur Meili, Michaelangelo Scalone, Xianqing Shi, Justin Vitale
  • (3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES
    Publication number: 20150045408
    Abstract: The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates The compounds of formula I and the corresponding hydrates are pharmaceutically active substances.
    Type: Application
    Filed: October 24, 2014
    Publication date: February 12, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Jean-Michel Adam, Charles Alois Dvorak, Daniel Fishlock, Eric R. Humphreys, Hans Iding, Christophe Pfleger, Pankaj D. Rege, Xianqing Shi, Justin Vitale, Shaoning Wang, Marian Zajac
  • PROCESS FOR SYNTHESIS OF AMINO-METHYL TETRALIN DERIVATIVES
    Publication number: 20120323040
    Abstract: Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L)??j1; Ru(E)(E?)(L)(D)??j2; wherein m, n, Ar, Y, R1E, E?, D, Z and L are as defined herein.
    Type: Application
    Filed: January 26, 2012
    Publication date: December 20, 2012
    Inventors: Kieran Durkin, Lawrence Emerson Fisher, Arthur MEILI, Michaelangelo Scalone, Xianqing Shi, Justin Vitale
  • Process for synthesis of amino-methyl tetralin derivatives
    Patent number: 8119842
    Abstract: Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L)??j1; Ru(E)(E?)(L)(D)??j2; wherein m, n, Ar, Y, R1 E, E?, D, Z and L are as defined herein.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: February 21, 2012
    Assignee: Roche Palo Alto LLP
    Inventors: Kieran Durkin, Lawrence Emerson Fisher, Arthur Meili, Michaelangelo Scalone, Xianqing Shi, Justin Vitale
  • PROCESS FOR SYNTHESIS OF AMINO-METHYL TETRALIN DERIVATIVES
    Publication number: 20100160682
    Abstract: Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L)??j1; Ru(E)(E?)(L)(D)??j2; wherein m, n, Ar, Y, R1 E, E?, D, Z and L are as defined herein.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 24, 2010
    Inventors: Kieran Durkin, Lawrence Emerson Fisher, Arthur Meili, Michaelangelo Scalone, Xianqing Shi, Justin Vitale