Patents by Inventor Xianquan Zhan

Xianquan Zhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Identifying Human Growth Hormone Proteoform (hGHP) Pattern Biomarker
    Publication number: 20220291230
    Abstract: The present disclosure provides a method for identifying a human growth hormone proteoform (hGHP) pattern biomarker. The method includes: collecting an hGH-secreting pituitary adenoma tissue sample and a normal pituitary tissue sample, and extracting tissue proteins, separately; conducting two-dimensional gel electrophoresis (2DGE), western blotting, and Coomassie brilliant blue (CBB) staining, and scanning visualized polyvinylidene fluoride (PVDF) membranes and 2D gels to obtain digital images; subjecting a corresponding protein in 2D gel spot to protein digestion with trypsin and purification, and conducting mass spectrometry identification and bioinformatics analysis to identify a GHP biomarker profile; and in combination with bioinformatics, using quantitative phosphoproteomics, quantitative ubiquitinomics, and quantitative acetylomics to identify post-translational modifications (PTMs) and splicing variations in GHP.
    Type: Application
    Filed: December 22, 2021
    Publication date: September 15, 2022
    Applicant: Shandong First Medical University & Shandong Academy of Medical Sciences
    Inventors: Xianquan ZHAN, Biao LI, Xiaowei WANG, Na LI
  • Method for identifying smoker or ex-smoker at risk of chronic obstructive pulmonary disease
    Patent number: 8530180
    Abstract: Specific nitroprotein biomarkers may be used as prognostic and diagnostic tools for COPD. Identification of certain specific nitroprotein biomarkers allows the development of targeted therapies aimed at prevention and treatment of COPD.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: September 10, 2013
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Dominic M. Desiderio, Xianquan Zhan
  • NITROPROTEIN BIOMARKERS FOR COPD
    Publication number: 20100183578
    Abstract: Specific nitroprotein biomarkers may be used as prognostic and diagnostic tools for COPD. Identification of certain specific nitroprotein biomarkers allows the development of targeted therapies aimed at prevention and treatment of COPD.
    Type: Application
    Filed: December 29, 2009
    Publication date: July 22, 2010
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Dominic M. DESIDERIO, Xianquan Zhan