Patents by Inventor Xianxhang Yu

Xianxhang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lytic peptide prodrugs
    Patent number: 7456146
    Abstract: A cytotoxin can be rendered non-toxic by charge neutralizing the amino acids salient to pore assembly and/or sterically inhibiting formation of the peptide's active conformation. In the presence of specific proteases, the inactive peptide or procytotoxin can be activated to assemble into its lytic conformation and selectively destroy a target cell.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: November 25, 2008
    Assignee: GHC Research Development Corporation
    Inventors: Xianxhang Yu, Thomas E. Wagner
  • Therapeutic pore-forming peptides
    Patent number: 7094750
    Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: August 22, 2006
    Assignee: Greenville Hospital System
    Inventors: Xianxhang Yu, Thomas E. Wagner
  • Therapeutic pore-forming peptides
    Publication number: 20020077454
    Abstract: A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.
    Type: Application
    Filed: May 9, 2001
    Publication date: June 20, 2002
    Inventors: Xianxhang Yu, Thomas E. Wagner
  • Lytic peptide prodrugs
    Publication number: 20020045736
    Abstract: A cytotoxin can be rendered non-toxic by charge neutralizing the amino acids salient to pore assembly and/or sterically inhibiting formation of the peptide's active conformation. In the presence of specific proteases, the inactive peptide or procytotoxin can be activated to assemble into its lytic conformation and selectively destroy a target cell.
    Type: Application
    Filed: August 27, 2001
    Publication date: April 18, 2002
    Inventors: Xianxhang Yu, Thomas E. Wagner