Patents by Inventor Xianzhao Kuang

Xianzhao Kuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of salts of fused penta-cyclic dihydrodiazepinocarbazolones, and uses thereof
    Patent number: 10899763
    Abstract: Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: January 26, 2021
    Assignee: BEIGENE, LTD.
    Inventors: Hexiang Wang, Xianzhao Kuang, Changyou Zhou
  • CRYSTALLINE FORMS OF SALTS OF FUSED TERA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARAZOLONES, AND USES THEREOF
    Publication number: 20200157103
    Abstract: Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.
    Type: Application
    Filed: February 27, 2018
    Publication date: May 21, 2020
    Inventors: Hexiang WANG, Xianzhao KUANG, Changyou ZHOU
  • Process for preparing a PARP inhibitor, crystalline forms, and uses thereof
    Patent number: 10457680
    Abstract: Provided are a process for preparing a Parp1/2 inhibitor, i.e., (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (hereinafter referred to as Compound A), crystalline forms (poly-morphs) of Compound A or hydrate or solvate thereof, methods for preparing the crystalline forms, and the use thereof.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: October 29, 2019
    Assignee: BEIGENE, LTD.
    Inventors: Hexiang Wang, Changyou Zhou, Bo Ren, Xianzhao Kuang
  • PROCESS FOR PREPARING A PARP INHIBITOR, CRYSTALLINE FORMS, AND USES THEREOF
    Publication number: 20190177325
    Abstract: Provided are a process for preparing a Parp1/2 inhibitor, i.e., (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (hereinafter referred to as Compound A), crystalline forms (poly-morphs) of Compound A or hydrate or solvate thereof, methods for preparing the crystalline forms, and the use thereof.
    Type: Application
    Filed: August 22, 2016
    Publication date: June 13, 2019
    Inventors: Hexiang WANG, Changyou Zhou, Bo Ren, Xianzhao Kuang