Abstract: Disclosed herein are cosmetic compositions comprising (a) at least one ethylenically unsaturated polymerizable compound and (b) at least one photoinitiator system comprising at least one photoinitiator having at least one absorption wavelength greater than about 350 nm. Also disclosed herein are methods of making up and/or enhancing the appearance of a keratinous substrate comprising (1) forming at least one film on the keratinous substrate by applying said cosmetic composition to the keratinous substrate and (2) exposing the film to UV-LED radiation.

Abstract: Disclosed is an improved an improved cap (40) for a bottle (1) which comprises a frangible device interface (100) including a valve part (52) and a tethered pull-ring (70), which frangible device interface may be removed from the cap preferably after the contents of the bottle are exhausted.

Abstract: A dispenser including a base unit with an actuation mechanism for dispensing liquid and a refill unit insertable into the base unit in an inverted configuration with its outlet lowermost for the supply of liquid to the base unit. The refill unit includes an annular wall projecting into the refill unit and defining an outlet from the refill unit, the annular wall being closable at its innermost end by a valve element biased onto the annular wall. The base unit includes a hollow spigot and an annular seal surrounding and spaced from the top of the spigot whereby insertion of the refill unit into the base unit causes the spigot to enter the annular wall and to lift the valve element from the annular wall to define a flow path from the refill unit, and the annular seal to seal between the spigot and the annular wall.

Abstract: Disclosed is a foaming pump mechanism for dispensing a foamable or foaming liquid composition, as well as dispensers for delivery of a foaming or foamable liquid composition therefrom, which is operable by a non-contact interaction with the user.

Abstract: A foaming pump mechanism for dispensing a foamable or foaming liquid composition, as well as dispensers for delivery of a foaming or foamable liquid composition therefrom which is operable by a non-contact interaction with the user. The foaming pump mechanism includes foam recovery.

Abstract: A relief valve (60) for a liquid container, the valve comprising a substantially conical body (50) extending into the container, and tapering inwardly away from an external wall of the container, at least one air inlet passage (62) through the substantially conical body; and a flexible diaphragm (53) extending over the conical body, being attached at its outer periphery around the substantially conical body and having a central opening surrounding the substantially conical body above the air inlet passage so as to seal the air inlet passage until the pressure within the container falls below a predetermined level.

Abstract: A fluid delivery system comprising a pump arranged to draw fluid, in use, from a reservoir (1) and dispense it through a dispensing tube (4), the pump comprising a cylinder (21) in which a piston (22) is reciprocally movable; an inlet into the cylinder; a one-way inlet valve (17) for controlling flow through the inlet; an outlet from the cylinder and leading to the dispensing tube; and an outlet valve (27) controlling flow through the outlet, wherein the piston is arranged to selectively contact the outlet valve to maintain it open during the initial portion of its downstroke and to allow it to close for the remainder of the downstroke.

Abstract: Disclosed herein are cosmetic compositions comprising (a) at least one styrene-maleic anhydride copolymer bearing at least one group chosen from styrylpyridine and styrylpyridinium groups and (b) at least one co-film forming agent and/or at least one plasticizer. The cosmetic composition optionally further comprises at least one pigment and at least one solvent. Also disclosed herein are methods for making up and/or enhancing the appearance of a keratinous substrate comprising (1) forming a film on the keratinous substrate by applying to said keratinous substrate a cosmetic composition comprising (a) at least one styrene-maleic anhydride copolymer bearing at least one group chosen from styrylpyridine and styrylpyridinium groups and (b) at least one co-film forming agent and/or at least one plasticizer and (2) exposing the film to radiation chosen from UV and visible light radiation.

Abstract: Disclosed is a foaming pump mechanism for dispensing a foamable or foaming liquid composition, as well as dispensers for delivery of a foaming or foamable liquid composition therefrom which is operable by a non-contact interaction with the user. The foaming pump mechanism includes an improved foam recovery means.

Abstract: A dispenser including a base unit with an actuation mechanism for dispensing liquid and a refill unit insertible into the base unit in an inverted configuration with its outlet lowermost for the supply of liquid to the base unit. The refill unit includes an annular wall projecting into the refill unit and defining an outlet from the refill unit, the annular wall being closable at its innermost end by a valve element biased onto the annular wall. The base unit includes a hollow spigot and an annular seal surrounding and spaced from the top of the spigot whereby insertion of the refill unit into the base unit causes the spigot to enter the annular wall and to lift the valve element from the annular wall to define a flow path from the refill unit, and the annular seal to seal between the spigot and the annular wall.

Abstract: Disclosed is an improved an improved cap (40) for a bottle (1) which comprises a frangible device interface (100) including a valve part (52) and a tethered pull-ring (70), which frangible device interface may be removed from the cap preferably after the contents of the bottle are exhausted.

Abstract: Disclosed is a foaming pump mechanism for dispensing a foamable or foaming liquid composition, as well as dispensers for delivery of a foaming or foamable liquid composition therefrom, which is operable by a non-contact interaction with the user.

Abstract: A liquid delivery system comprising a base unit (2) comprising a liquid inlet in an upwardly facing surface, a liquid duct leading from the inlet to a liquid outlet above the liquid inlet; a pump for pumping the liquid from the inlet to the outlet; a motor to drive the pump; and a shroud extending upwardly in a manner which surrounds the inlet, the system further comprising a vessel (1) received within the shroud in an inverted configuration with its outlet lowermost and in communication with the fluid inlet, the vessel (1) having a refill opening (20) towards the end opposite to the outlet.

Abstract: A bottle (1) with a secure cap (7), comprising a bottle having an open neck (2) and a first retaining flange (3) around at least a portion of the neck; and a push-on cap (7) fitted over the neck (2), the cap having an outlet with a valve (32) for controlling flow through the outlet and a second retaining flange (9) positioned so that, upon placement of the cap (7) on the bottle (1), the first and second retaining flanges (3,9) deflect relatively to one another as they pass and snap back into place once they have passed with a shoulder (41) of the first retaining flange engaging a shoulder (131) on the second retaining flange to hold the cap securely on the bottle.

Abstract: A fluid delivery system comprising a pump arranged to draw fluid, in use, from a reservoir (1) and dispense it through a dispensing tube (4), the pump comprising a cylinder (21) in which a piston (22) is reciprocally movable; an inlet into the cylinder; a one-way inlet valve (17) for controlling flow through the inlet; an outlet from the cylinder and leading to the dispensing tube; and an outlet valve (27) controlling flow through the outlet, wherein the piston is arranged to selectively contact the outlet valve to maintain it open during the initial portion of its downstroke and to allow it to close for the remainder of the downstroke.

Abstract: Methionine aminopeptidases catalyse the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. A newly-discovered enzyme, designated methionine aminopeptidase type-3 (MetAP-3), has a substrate specificity which is similar to MetAP-1 and MetAP-2, although it is not inhibited by fumagillin, an irreversible inhibitor of MetAP-2. MetAP-3 also preferentially localizes to mitochondria, unlike MetAP-1 and MetAP-2, which accumulate in the cytoplasm. One embodiment of the present invention relates to human cDNAs encoding polypeptides comprising MetAP-3. Other embodiments of the invention relate to nucleic acid molecules derived from these cDNAs, including complements, homologues, and fragments thereof, and methods of using these nucleic acid molecules, to generate polypeptides and fragments thereof.

Abstract: Methionine aminopeptidases catalyse the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. A newly-discovered enzyme, designated methionine aminopeptidase type-3 (MetAP-3), has a substrate specificity which is similar to MetAP-1 and MetAP-2, although it is not inhibited by fumagillin, an irreversible inhibitor of MetAP-2. MetAP-3 also preferentially localizes to mitochondria, unlike MetAP-1 and MetAP-2, which accumulate in the cytoplasm. One embodiment of the present invention relates to human cDNAs encoding polypeptides comprising MetAP-3. Other embodiments of the invention relate to nucleic acid molecules derived from these cDNAs, including complements, homologues, and fragments thereof, and methods of using these nucleic acid molecules, to generate polypeptides and fragments thereof.