Abstract: The present invention relates to an antibody-drug conjugate (ADC) targeting Claudin18.2 and a composition containing the molecule. The present invention further relates to therapeutic and diagnostic uses of the antibodies and antibody fragments.

Abstract: A drilling tool has an upstream drilling string, a downstream drilling bit, and a percussive device connected between the upstream drilling string and the downstream drilling bit. In a first state, the upstream drilling string is generated with elastic compression by the percussive device, and in a second state, the upstream drilling string releases the elastic compression to apply impacts on the downstream drilling bit through the percussive device. The drilling tool has a prolonged service life and can effectively reduce the drilling cost.

Abstract: Provided are a highly specific Taq DNA polymerase variant and the use thereof in genome editing and gene mutation detection. All polar amino acids, directly interacting with a primer/template complex, on a Taq enzyme are selected to be mutated one by one to obtain 40 Taq variants, and extensive random mutagenesis is performed on the basis of the sequences of the variants and the sequences of wild type Taq enzymes to create a Taq mutant library. Then, a series of Taq mutants with a high specificity are screened on a qPCR screening system by means of taking a genome editing indels plasmid as a template, wherein the Taq mutants exhibit great advantages in CRISPR/Cas9 editing efficiency evaluation and single-cell cloning genotyping.

Abstract: A drilling tool includes an outer cylinder; a power rotary shaft arranged in an inner chamber of the outer cylinder; a percussion generator arranged below the power rotary shaft, having a transmission shaft extending in the outer cylinder and can be driven by the power rotary shaft to rotate around its axis, an output main shaft engaged with a lower end of the transmission shaft so as to be driven by the transmission shaft to rotate about its axis and is movable relative to the transmission shaft along an axial direction, and an percussion assembly The percussion assembly is arranged between an annulus formed between the upper end of the output main shaft and the outer cylinder and can generate reciprocating impact along the axial direction on the output main shaft. A drilling bit connected with the output main shaft extending out of the inner chamber of the outer cylinder.

Abstract: A speed-enhancing drilling tool includes an upstream drill string (10), which has a drive motor and a first driving rod coupled therewith, a downstream drilling bit; and a percussive device connected between the upstream drilling string and the downstream drilling bit. The first driving rod extending axially and the drive motor are configured to drive the first driving rod in rotation. The percussive device has a rotary driving part having an upper end engaged with the first driving rod to rotate together therewith; and a rotary working part having an upper end engaged with a lower end of the rotary driving part and a lower end connected with the downstream drilling bit. The rotary working part can be driven by the rotary driving part to rotate about its axis, and axially movable relative thereto; and a percussion generating part arranged around the rotary working part.

Abstract: A drilling speed-enhancing device has an outer cylinder a rotary main shaft arranged in an inner chamber of the outer cylinder and configured to rotate around its own axis; an output main shaft arranged below the rotary main shaft and configured to be driven by the rotary main shaft to rotate around its own axis, a lower end of the output main shaft extending out of the inner chamber of the outer cylinder for connecting with a drilling bit of a dual-drive drilling tool; and a percussion generator arranged between the output main shaft and the outer cylinder. The percussion generator can drive the outer cylinder and the rotary main shaft to move upward relative to the output main shaft, so that under action of WOB, the rotary main shaft and the outer cylinder move downward to generate impact on the output main shaft.

Abstract: A preparation method of a nanotube hierarchically structured lithium titanate includes the steps of: S1. dispersing a titanium source into an aqueous solution containing lithium hydroxide and hydrogen peroxide and stirring to obtain a mixed solution; S2. subjecting the mixed solution obtained in step S1 to a reaction by heating to obtain a precursor having a nanowire-like structure; S3. subjecting the precursor having a nanowire-like structure obtained in step S2 to separation and drying; S4. subjecting the precursor having a nanowire-like structure after separation and drying to a low-temperature annealing treatment; S5. subjecting the precursor having a nanowire-like structure after the low-temperature annealing treatment to a liquid thermal reaction to obtain the nanotube hierarchically structured lithium titanate. The method includes a simple process and easily controllable process parameters, and may be easily scaled-up for industrial production.

Abstract: A process for preparing a titanic acid salt, titanic acid, and titanium oxide having a controllable particle size and a hierarchical structure, wherein the process includes the steps of: preparing a titanium-containing peroxo-complex solution; adding a basic metal compound to the titanium-containing peroxo-complex solution to form a mixture solution; adding one of polyvinyl alcohol, hydroxypropyl methyl cellulose, and polyethylene glycol to the mixture solution to form a precursor dispersion; and subjecting the precursor dispersion to a solvothermal reaction to obtain the titanic acid salt having a hierarchical structure. The process for preparing a titanic acid salt, titanic acid, and titanium oxide having a controllable particle size and a hierarchical structure, can not only realize the regulation of morphology and particle diameter of constituent units in the hierarchical structure, but also can achieve the regulation of particle size in the hierarchical structure.

Abstract: A drilling tool has an upstream drilling string, a downstream drilling bit, and a percussive device connected between the upstream drilling string and the downstream drilling bit. In a first state, the upstream drilling string is generated with elastic compression by the percussive device, and in a second state, the upstream drilling string releases the elastic compression to apply impacts on the downstream drilling bit through the percussive device. The drilling tool has a prolonged service life and can effectively reduce the drilling cost.

Abstract: The present invention provides a nanostructured titanic acid salt and a preparation process and use thereof. The process comprises preparing a dispersion containing titanium peroxy complex; slowly adding a metal compound to the dispersion containing the titanium peroxy complex to form a solution; adding an alcohol to the solution under normal temperature and normal pressure to produce the nanostructured titanic acid salt precursor precipitate in the solution, and separating the precipitate to obtain the titanic acid salt precursor; drying the precursor, and then heat treating it to obtain the nanostructured titanic acid salt product. The present invention provides a process for preparing a titanic acid salt with simple preparation process, easy control for process parameters and easy large-scale industrial production.

Abstract: A speed-enhancing drilling tool includes an upstream drill string (10), which has a drive motor and a first driving rod coupled therewith, a downstream drilling bit; and a percussive device connected between the upstream drilling string and the downstream drilling bit. The first driving rod extending axially and the drive motor are configured to drive the first driving rod in rotation. The percussive device has a rotary driving part having an upper end engaged with the first driving rod to rotate together therewith; and a rotary working part having an upper end engaged with a lower end of the rotary driving part and a lower end connected with the downstream drilling bit. The rotary working part can be driven by the rotary driving part to rotate about its axis, and axially movable relative thereto; and a percussion generating part arranged around the rotary working part.

Abstract: A drilling speed-enhancing device has an outer cylinder; a rotary main shaft arranged in an inner chamber of the outer cylinder and configured to rotate around its own axis; an output main shaft arranged below the rotary main shaft and configured to be driven by the rotary main shaft to rotate around its own axis, a lower end of the output main shaft extending out of the inner chamber of the outer cylinder for connecting with a drilling bit of a dual-drive drilling tool; and a percussion generator arranged between the output main shaft and the outer cylinder. The percussion generator can drive the outer cylinder and the rotary main shaft to move upward relative to the output main shaft, so that under action of WOB, the rotary main shaft and the outer cylinder move downward to generate impact on the output main shaft.

Abstract: A drilling tool includes an outer cylinder; a power rotary shaft arranged in an inner chamber of the outer cylinder; a percussion generator arranged below the power rotary shaft, having a transmission shaft extending in the outer cylinder and can be driven by the power rotary shaft to rotate around its axis, an output main shaft engaged with a lower end of the transmission shaft so as to be driven by the transmission shaft to rotate about its axis and is movable relative to the transmission shaft along an axial direction, and an percussion assembly The percussion assembly is arranged between an annulus formed between the upper end of the output main shaft and the outer cylinder and can generate reciprocating impact along the axial direction on the output main shaft. A drilling bit connected with the output main shaft extending out of the inner chamber of the outer cylinder.

Abstract: The present disclosure provides a gas mixture-based laser-induced breakdown spectroscopy (LIBS) signal enhancement apparatus and a heavy metal detection method. The apparatus includes a pulsed solid-state laser 1, an optical path system 2, a spherical gas mixing chamber 3, a fiber-optic receiver 4, a spectrometer 5, and a controller 8. The optical path system 2 is connected to the pulsed solid-state laser 1. The spherical gas mixing chamber 3 is disposed opposite to the optical path system 2. The fiber-optic receiver 4 is disposed opposite to the spherical gas mixing chamber 3. The spectrometer 5 is connected to the fiber-optic receiver 4. The controller 8 is connected to the spectrometer 5 and the pulsed solid-state laser 1. The spectrometer 5 determines LIBS information based on an optical signal received by the fiber-optic receiver 4. The controller 8 determines a LIBS spectrogram based on the LIBS information.

Abstract: The present invention provides a linear porous lithium titanate material, preparation and product thereof. The material comprises a lithium titanate material having a crystal phase which is a spinel type, wherein the lithium titanate material has a linear structure having an aspect ratio of greater than 10, and the linear lithium titanate material has a porous structure; wherein the linear porous lithium titanate material has a structure composed of a plurality of particles having an oriented growth direction. The material has a long-axis structure which facilitates the effective migration of electrons, a porous structure which facilitates the rapid intercalation and deintercalation process of lithium ions, sodium ions or potassium ions, and a large specific surface area which facilitates the contact area between the electrolyte solution and the electrodes and reduces the current density, thus is excellent in a rapid charge-discharge performance of the battery.

Abstract: A linear hierarchical structure lithium titanate material, preparation and application thereof. The crystal phase of the lithium titanate material is a spinel-type crystal phase or a monoclinic crystal phase or a composite crystal phase thereof; the lithium titanate material is mainly composed of a linear hierarchical structure; the linear hierarchical structure has an aspect ratio larger than 10; and the surface components of the linear hierarchical structure are nanosheets. The long-axis of the linear structure facilitates the effective migration of electrons, and the sheet-like hierarchical structure facilitates the rapid intercalation and deintercalation process of lithium ions, sodium ions or potassium ions, and a large specific surface area facilitates the contact area between the electrolyte solution and the electrodes and reduces the current density, thus is excellent in a rapid charge-discharge performance of the battery.