Patents by Inventor Xiaodan LIU
Xiaodan LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240167947Abstract: The present invention discloses a CEEMDAN-based method for screening and monitoring soil moisture stress in farmland, characterised by the steps: preprocessing of remote sensing images, construction of NDVI long time series, CEEMDAN decomposition, calculation of statistical descriptors, screening of soil moisture stress sequences, ground data measurement, construction of soil moisture stress characteristic curves, fitting of soil moisture stress response characteristic curves and predicting the content of soil moisture stress. The invention adopts CEEMDAN decomposition, which solves the problems of noise residue and low reconstruction accuracy in the previous methods, and the high reconstruction accuracy of decomposed component data is more conducive to capturing the transient effects of soil moisture stress, and realizes the screening and extraction of soil moisture stress by combining with the ground measured data.Type: ApplicationFiled: May 5, 2023Publication date: May 23, 2024Inventors: Xuqing Li, Yongtao Jin, Xiaodan Wang, Guohong Li, Xingfa Gu, Yuanping Liu, Xia Zhu, Qichao Zhao, Yuyan Liu, Xiufeng Yang, Yancang Wang, Tianjiao Liu, Wenhao Zhang, Chenyu Zhao
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Publication number: 20240167004Abstract: Provided are a highly specific Taq DNA polymerase variant and the use thereof in genome editing and gene mutation detection. All polar amino acids, directly interacting with a primer/template complex, on a Taq enzyme are selected to be mutated one by one to obtain 40 Taq variants, and extensive random mutagenesis is performed on the basis of the sequences of the variants and the sequences of wild type Taq enzymes to create a Taq mutant library. Then, a series of Taq mutants with a high specificity are screened on a qPCR screening system by means of taking a genome editing indels plasmid as a template, wherein the Taq mutants exhibit great advantages in CRISPR/Cas9 editing efficiency evaluation and single-cell cloning genotyping.Type: ApplicationFiled: July 15, 2021Publication date: May 23, 2024Applicants: SHANGHAI TURTLE TECHNOLOGY CO., LTD., SHANDONG UNIVERSITYInventors: Qilai HUANG, Xiaodan LIU, Ping DU, Bo LI
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Publication number: 20240150346Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.Type: ApplicationFiled: January 27, 2022Publication date: May 9, 2024Inventors: Yunlong SONG, Chen ZHANG, Fang GAO, Weimin LIU, Qun DANG, Pan LI, Zhou YIN, Xin CAI, Xiaodan FU, Jianbin MA
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Publication number: 20240141069Abstract: An anti-MASP-2 antibody and use thereof. The anti-MASP-2 antibody specifically binds to a human MASP-2 protein at a KD value of about 2E-09M or less, and the anti-MASP-2 antibody specifically binds to a cynomolgus monkey MASP-2 protein at a KD value of about 2E-09M or less. Disclosed are an immunoconjugate containing the anti-MASP-2 antibody, a method for preparing the anti-MASP-2 antibody, and use of the anti-MASP-2 antibody.Type: ApplicationFiled: June 7, 2022Publication date: May 2, 2024Inventors: Xiaowu LIU, Xiaodan CAO, Jianqiu SONG, Zongda WANG, Peipei LIU, Jianjian ZHANG, Chunyin GU, Sujun DENG, Zhongzong PAN, Xueping WANG
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Publication number: 20240124576Abstract: The present invention provides a preparation of a Siglec-15 binding protein and the use thereof, and specifically relates to an isolated antigen-binding protein, which comprises HCDR3. Provided is the use of the antigen-binding protein in the prevention and treatment of diseases.Type: ApplicationFiled: February 22, 2022Publication date: April 18, 2024Inventors: Xinxiu Yang, Chunyin GU, Zongda WANG, Xiaodan CAO, Xiaowu LIU, Peipei LIU, Lu YANG, Sujun DENG, Zhongzong PAN, Xueping WANG
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Publication number: 20240117034Abstract: Provided is an GARP protein antibody, and a cell comprising or expressing the GA RP protein antibody. The GARP protein antibody binds to human GARP/human TGF-?1 complex with a KD value of about 1.0E-12 or less. Also provided are a pharmaceutical combination comprising the GARP protein antibody and an immune checkpoint inhibitor and use thereof.Type: ApplicationFiled: January 17, 2022Publication date: April 11, 2024Applicants: SHANGHAI JEMINCARE PHARMACEUTICAL CO., LTD., JIANGXI JEMINCARE GROUP CO., LTD.Inventors: Jianjian ZHANG, Zhongzong PAN, Xinxiu YANG, Xiaowu LIU, Lu YANG, Peipei LIU, Xiaodan CAO, Sujun DENG, Xueping WANG
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Patent number: 11946342Abstract: A drilling tool includes an outer cylinder; a power rotary shaft arranged in an inner chamber of the outer cylinder; a percussion generator arranged below the power rotary shaft, having a transmission shaft extending in the outer cylinder and can be driven by the power rotary shaft to rotate around its axis, an output main shaft engaged with a lower end of the transmission shaft so as to be driven by the transmission shaft to rotate about its axis and is movable relative to the transmission shaft along an axial direction, and an percussion assembly The percussion assembly is arranged between an annulus formed between the upper end of the output main shaft and the outer cylinder and can generate reciprocating impact along the axial direction on the output main shaft. A drilling bit connected with the output main shaft extending out of the inner chamber of the outer cylinder.Type: GrantFiled: September 11, 2020Date of Patent: April 2, 2024Assignees: China Petroleum & Chemical Corporation, Sinopec Petroleum Engineering Technology Research Institute Co., Ltd.Inventors: Baoping Lu, Haiping Zhang, Mingguang Sun, Jiachang Wang, Yanbin Zang, Xinghua Tao, Lingchao Xuan, Xiaodan Liu, Renlong Zhang, Lishuang Wang
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Patent number: 11920437Abstract: A speed-enhancing drilling tool includes an upstream drill string (10), which has a drive motor and a first driving rod coupled therewith, a downstream drilling bit; and a percussive device connected between the upstream drilling string and the downstream drilling bit. The first driving rod extending axially and the drive motor are configured to drive the first driving rod in rotation. The percussive device has a rotary driving part having an upper end engaged with the first driving rod to rotate together therewith; and a rotary working part having an upper end engaged with a lower end of the rotary driving part and a lower end connected with the downstream drilling bit. The rotary working part can be driven by the rotary driving part to rotate about its axis, and axially movable relative thereto; and a percussion generating part arranged around the rotary working part.Type: GrantFiled: September 11, 2020Date of Patent: March 5, 2024Assignees: China Petroleum & Chemical Corporation, Sinopec Petroleum Engineering Technology Research Institute Co., Ltd.Inventors: Haiping Zhang, Shidong Ding, Mingguang Sun, Jiachang Wang, Yanbin Zang, Xinghua Tao, Lishuang Wang, Xiaodan Liu, Lingchao Xuan, Renlong Zhang
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Patent number: 11898417Abstract: A drilling speed-enhancing device has an outer cylinder a rotary main shaft arranged in an inner chamber of the outer cylinder and configured to rotate around its own axis; an output main shaft arranged below the rotary main shaft and configured to be driven by the rotary main shaft to rotate around its own axis, a lower end of the output main shaft extending out of the inner chamber of the outer cylinder for connecting with a drilling bit of a dual-drive drilling tool; and a percussion generator arranged between the output main shaft and the outer cylinder. The percussion generator can drive the outer cylinder and the rotary main shaft to move upward relative to the output main shaft, so that under action of WOB, the rotary main shaft and the outer cylinder move downward to generate impact on the output main shaft.Type: GrantFiled: September 11, 2020Date of Patent: February 13, 2024Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SINOPEC PETROLEUM ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.Inventors: Jiachang Wang, Haiping Zhang, Yanbin Zang, Mingguang Sun, Guangjun Ma, Lishuang Wang, Lingchao Xuan, Xiaodan Liu, Renlong Zhang
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Patent number: 11858827Abstract: A preparation method of a nanotube hierarchically structured lithium titanate includes the steps of: S1. dispersing a titanium source into an aqueous solution containing lithium hydroxide and hydrogen peroxide and stirring to obtain a mixed solution; S2. subjecting the mixed solution obtained in step S1 to a reaction by heating to obtain a precursor having a nanowire-like structure; S3. subjecting the precursor having a nanowire-like structure obtained in step S2 to separation and drying; S4. subjecting the precursor having a nanowire-like structure after separation and drying to a low-temperature annealing treatment; S5. subjecting the precursor having a nanowire-like structure after the low-temperature annealing treatment to a liquid thermal reaction to obtain the nanotube hierarchically structured lithium titanate. The method includes a simple process and easily controllable process parameters, and may be easily scaled-up for industrial production.Type: GrantFiled: August 29, 2019Date of Patent: January 2, 2024Assignee: PETROCHINA COMPANY LIMITEDInventors: Xu Jin, Jianming Li, He Liu, Hang Jiao, Xiaoqi Wang, Liang Sun, Xiaodan Liu
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Patent number: 11565944Abstract: A process for preparing a titanic acid salt, titanic acid, and titanium oxide having a controllable particle size and a hierarchical structure, wherein the process includes the steps of: preparing a titanium-containing peroxo-complex solution; adding a basic metal compound to the titanium-containing peroxo-complex solution to form a mixture solution; adding one of polyvinyl alcohol, hydroxypropyl methyl cellulose, and polyethylene glycol to the mixture solution to form a precursor dispersion; and subjecting the precursor dispersion to a solvothermal reaction to obtain the titanic acid salt having a hierarchical structure. The process for preparing a titanic acid salt, titanic acid, and titanium oxide having a controllable particle size and a hierarchical structure, can not only realize the regulation of morphology and particle diameter of constituent units in the hierarchical structure, but also can achieve the regulation of particle size in the hierarchical structure.Type: GrantFiled: August 29, 2019Date of Patent: January 31, 2023Assignee: PETROCHINA COMPANY LIMITEDInventors: Jianming Li, Xu Jin, He Liu, Xiaodan Liu, Xiaoqi Wang, Liang Sun
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Publication number: 20230020998Abstract: A drilling tool has an upstream drilling string, a downstream drilling bit, and a percussive device connected between the upstream drilling string and the downstream drilling bit. In a first state, the upstream drilling string is generated with elastic compression by the percussive device, and in a second state, the upstream drilling string releases the elastic compression to apply impacts on the downstream drilling bit through the percussive device. The drilling tool has a prolonged service life and can effectively reduce the drilling cost.Type: ApplicationFiled: September 11, 2020Publication date: January 19, 2023Inventors: Haiping ZHANG, Yanbin ZANG, Guangjun MA, Jiachang WANG, Mingguang SUN, Xinghua TAO, Lingchao XUAN, Xiaodan LIU, Renlong ZHANG
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Patent number: 11554966Abstract: The present invention provides a nanostructured titanic acid salt and a preparation process and use thereof. The process comprises preparing a dispersion containing titanium peroxy complex; slowly adding a metal compound to the dispersion containing the titanium peroxy complex to form a solution; adding an alcohol to the solution under normal temperature and normal pressure to produce the nanostructured titanic acid salt precursor precipitate in the solution, and separating the precipitate to obtain the titanic acid salt precursor; drying the precursor, and then heat treating it to obtain the nanostructured titanic acid salt product. The present invention provides a process for preparing a titanic acid salt with simple preparation process, easy control for process parameters and easy large-scale industrial production.Type: GrantFiled: August 29, 2019Date of Patent: January 17, 2023Assignee: PetroChina Company LimitedInventors: Xu Jin, Jianming Li, Xiaoqi Wang, Hang Jiao, Liang Sun, Xiaodan Liu
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Publication number: 20230003085Abstract: A drilling speed-enhancing device has an outer cylinder; a rotary main shaft arranged in an inner chamber of the outer cylinder and configured to rotate around its own axis; an output main shaft arranged below the rotary main shaft and configured to be driven by the rotary main shaft to rotate around its own axis, a lower end of the output main shaft extending out of the inner chamber of the outer cylinder for connecting with a drilling bit of a dual-drive drilling tool; and a percussion generator arranged between the output main shaft and the outer cylinder. The percussion generator can drive the outer cylinder and the rotary main shaft to move upward relative to the output main shaft, so that under action of WOB, the rotary main shaft and the outer cylinder move downward to generate impact on the output main shaft.Type: ApplicationFiled: September 11, 2020Publication date: January 5, 2023Inventors: Jiachang WANG, Haiping ZHANG, Yanbin ZANG, Mingguang SUN, Guangjun MA, Lishuang WANG, Lingchao XUAN, Xiaodan LIU, Renlong ZHANG
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Publication number: 20230003084Abstract: A speed-enhancing drilling tool includes an upstream drill string (10), which has a drive motor and a first driving rod coupled therewith, a downstream drilling bit; and a percussive device connected between the upstream drilling string and the downstream drilling bit. The first driving rod extending axially and the drive motor are configured to drive the first driving rod in rotation. The percussive device has a rotary driving part having an upper end engaged with the first driving rod to rotate together therewith; and a rotary working part having an upper end engaged with a lower end of the rotary driving part and a lower end connected with the downstream drilling bit. The rotary working part can be driven by the rotary driving part to rotate about its axis, and axially movable relative thereto; and a percussion generating part arranged around the rotary working part.Type: ApplicationFiled: September 11, 2020Publication date: January 5, 2023Inventors: Haiping ZHANG, Shidong DING, Mingguang SUN, Jiachang WANG, Yanbin ZANG, Xinghua TAO, Lishuang WANG, Xiaodan LIU, Lingchao XUAN, Renlong ZHANG
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Publication number: 20220412165Abstract: A drilling tool includes an outer cylinder; a power rotary shaft arranged in an inner chamber of the outer cylinder; a percussion generator arranged below the power rotary shaft, having a transmission shaft extending in the outer cylinder and can be driven by the power rotary shaft to rotate around its axis, an output main shaft engaged with a lower end of the transmission shaft so as to be driven by the transmission shaft to rotate about its axis and is movable relative to the transmission shaft along an axial direction, and an percussion assembly The percussion assembly is arranged between an annulus formed between the upper end of the output main shaft and the outer cylinder and can generate reciprocating impact along the axial direction on the output main shaft. A drilling bit connected with the output main shaft extending out of the inner chamber of the outer cylinder.Type: ApplicationFiled: September 11, 2020Publication date: December 29, 2022Inventors: Baoping LU, Haiping ZHANG, Mingguang SUN, Jiachang WANG, Yanbin ZANG, Xinghua TAO, Lingchao XUAN, Xiaodan LIU, Renlong ZHANG, Lishuang WANG
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Patent number: D985229Type: GrantFiled: February 16, 2023Date of Patent: May 9, 2023Assignee: Guangzhou Melody Clothing Co., Ltd.Inventor: Xiaodan Liu
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Patent number: D1008604Type: GrantFiled: August 3, 2023Date of Patent: December 26, 2023Assignee: Guangzhou Melody Clothing Co., Ltd.Inventor: Xiaodan Liu
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Patent number: D1010974Type: GrantFiled: August 3, 2023Date of Patent: January 16, 2024Assignee: Guangzhou Melody Clothing Co., Ltd.Inventor: Xiaodan Liu
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Patent number: D1010975Type: GrantFiled: August 7, 2023Date of Patent: January 16, 2024Assignee: Guangzhou Melody Clothing Co., Ltd.Inventor: Xiaodan Liu