Abstract: Provided in the present invention is an antibody or an antigen binding protein thereof. The antibody or the antigen binding protein thereof can specifically bind to human CD3 or human GPRC5D protein or MUC16, or specifically bind to human CD3 and a second antigen. Further provided in the present invention are a nucleic acid molecule encoding the antibody, an expression vector for expressing the antibody, a host cell and a preparation method therefor. Also provided in the present invention is a diagnosis and treatment method using the antibody of the invention.

Abstract: The present application provides a processing method of a metal composite structure including a first metal layer and a second metal layer stacked on the first metal layer. The processing method includes the steps of defining a first through hole in the first metal layer, and drilling in the first through hole toward the second metal layer to form a traction hole in the second metal layer. Then, hot melt drilling is performed on a surface of the second metal layer away from the first metal layer toward the first through hole, thereby causing the second metal layer to crack under a traction force of the traction hole to form a second through hole, and a portion of the second metal layer to be melted and squeezed to form a bushing which adheres to at least a portion of a sidewall of the first through hole.

Abstract: Some embodiments include an integrated assembly having a source structure, and having a stack of alternating conductive levels and insulative levels over the source structure. Cell-material-pillars pass through the stack. The cell-material-pillars are arranged within a configuration which includes a first memory-block-region and a second memory-block-region. The cell-material-pillars include channel material which is electrically coupled with the source structure. Memory cells are along the conductive levels and include regions of the cell-material-pillars. A panel is between the first and second memory-block-regions. The panel has a first material configured as a container shape. The container shape defines opposing sides and a bottom of a cavity. The panel has a second material within the cavity. The second material is compositionally different from the first material. Some embodiments include methods of forming integrated assemblies.

Abstract: An information transmission method and a network device, the network device including a transceiver, a processor, and a non-transitory storage medium storing a computer program for execution by the processor. The computer program includes instructions to receive a first frame through the receiver, where an extended schedule element of the first frame has a field indicating communication between network devices is supported, and where the extended schedule element further has a source association identifier and a destination association identifier, and control the transceiver to transmit information to a first network device when both the first network device and the network device support communication between network devices, where a value of the source association identifier and a value of the destination association identifier are each 0.

Abstract: Described herein are systems, methods, and instrumentalities associated with automatic determination of hemodynamic characteristics. An apparatus as described may implement a first artificial neural network (ANN) and a second ANN. The first ANN may model a mapping from a set of 3D points associated with one or more blood vessels to a set of hemodynamic characteristics of the one or more blood vessels, while the second ANN may generate, based on a geometric relationship of the set of points in a 3D space, parameters for controlling the mapping. The apparatus may obtain a 3D anatomical model representing at least one blood vessel of a patient based on one or more medical images of the patient, and determine, based on the first ANN and the second ANN, a hemodynamic characteristic of the at least one blood vessel of the patient at a target location of the 3D anatomical model.

Abstract: Disclosed is a method for predicting a lightning outage rate of a high-speed railway contact system based on a lightning location, including the steps: (1) evaluating location errors of cloud-to-ground lightning flashes along a high-speed railway line; (2) evaluating a detection efficiency of the cloud-to-ground lightning flashes along the high-speed railway line; (3) calculating a ground flash density along the high-speed railway line; (4) fitting a cumulative probability function of the lightning current amplitudes along the high-speed railway line; and (5) constructing a calculation model for the lightning outage rate of the high-speed railway contact system.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: The present disclosure relates to a radiation system. The system may include a treatment assembly, an imaging assembly, a first gantry, and a second gantry. The treatment assembly may include a first radiation source configured to deliver a treatment beam and have a treatment region. The first gantry may be configured to support the first radiation source. The imaging assembly may include a second radiation source and a radiation detector. The second radiation source may be configured to deliver an imaging beam and the radiation detector may be configured to detect at least a portion of the imaging beam. The imaging assembly may have an imaging region. The second gantry may be configured to support the second radiation source and the radiation detector, wherein the second radiation source is located within the second gantry. The treatment region and the imaging region at least partially overlap.

Abstract: A calibration device includes a base, a support column coupled to the base and extending in a first direction, and a crossbar coupled to the support column. The crossbar includes a positioning base and a carrier. The positioning base is fixed to the support column. The carrier is coupled to the positioning base and rotatable about a second direction perpendicular to the first direction. The carrier includes a distance sensor and a calibration platform. The calibration platform mounts a depth camera. The carrier is configured to rotate about the second direction to rotate an optical axis of the depth camera in a first calibration plane defined by the first direction and a third direction. The third direction is perpendicular to the first direction and the second direction.

Abstract: A simulation system and a method thereof are disclosed. In the simulation system, a system power transmission model, and analog current time-domain model and digital current time-domain model are connected to obtain power noise generated after a supply current is obtained; jitter time-domain information of each interface connection circuit model under the power noise is obtained based on transmission of a clock signal outputted from a phase lock loop, by a simulation program; next, a voltage step response of a voltage measurement point when a clock terminal of each interface connection circuit model receives an ideal signal, is simulated by the simulation program to generate a first voltage time-domain model; a system waveform is generated based on the jitter time-domain information of each interface connection circuit model under the power noise, the first voltage time-domain model and data transmission, thereby obtaining an eye diagram and time-domain jitter distribution.

Abstract: A floor board, and a method and apparatus for manufacturing same. The floor board (100) comprises a polyurethane-foam board (110). The polyurethane-foam board (110) is made of a polyurethane foam material foamed from a polyurethane foam raw material. The polyurethane-foam board (110) is provided with a plurality of linear members (120) passing though the polyurethane-foam board in a predetermined direction. The plurality of linear members (120) are arranged at intervals. The polyurethane-foam board (110) is foaming-molded by continuous drawing.

Abstract: The present disclosure relates to a radiation system. The system may include a treatment assembly, an imaging assembly, a first gantry, and a second gantry. The treatment assembly may include a first radiation source configured to deliver a treatment beam and have a treatment region. The first gantry may be configured to support the first radiation source. The imaging assembly may include a second radiation source and a radiation detector. The second radiation source may be configured to deliver an imaging beam and the radiation detector may be configured to detect at least a portion of the imaging beam. The imaging assembly may have an imaging region. The second gantry may be configured to support the second radiation source and the radiation detector, wherein the second radiation source is located within the second gantry. The treatment region and the imaging region at least partially overlap.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: The present disclosure relates a multi-leaf collimator. The multi-leaf collimator may include a plurality of leaf modules. Each leaf module of the plurality of leaf modules may include a leaf configured to shield a portion of beams emitted by a radiation source. The leaf may be movable along a guide rail of the multi-leaf collimator. Each leaf module may also include a drive mechanism including a first drive component and a second drive component. The first drive component and the second drive component may be both connected to the leaf. The first drive component and the second drive component may jointly actuate the leaf to move along the guide rail.

Abstract: The present disclosure relates to a collimator. The collimator may include a motor, a transmission unit having a first end and a second end, and a leaf unit having a leaf. The first end of the transmission unit may be connected to the motor and the second end of the transmission unit may be connected to the leaf. The present disclosure also relates to a collimator system. The collimator system may include a leaf module having a leaf, a driving module having a motor configured to drive the leaf, and a processing module to generate a movement profile of the leaf. The movement profile of the leaf may include a first speed during a first stage, a second speed of the leaf during a second stage, and a third speed of the leaf during a third stage.

Abstract: The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt or prodrug thereof.

Abstract: A system and method for image-guided radiotherapy are provided. The system may include a treatment assembly and an imaging assembly. The treatment assembly may include a first radiation source configured to deliver a treatment beam. The treatment assembly may have a treatment region relating to an object. The imaging assembly may include a second radiation source and a radiation detector. The second radiation source may be configured to deliver an imaging beam, and the radiation detector may be configured to detect at least a portion of the imaging beam. The imaging assembly may have an imaging region relating to the object. The first radiation source may be rotatable in a first plane, and the second radiation source may be rotatable in a second plane different from the first plane, such that the treatment region and the imaging region at least partially overlap.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: The present disclosure relates to a collimator. The collimator may include a motor, a transmission unit having a first end and a second end, and a leaf unit having a leaf. The first end of the transmission unit may be connected to the motor and the second end of the transmission unit may be connected to the leaf. The present disclosure also relates to a collimator system. The collimator system may include a leaf module having a leaf, a driving module having a motor configured to drive the leaf, and a processing module to generate a movement profile of the leaf. The movement profile of the leaf may include a first speed during a first stage, a second speed of the leaf during a second stage, and a third speed of the leaf during a third stage.