Patents by Inventor Xiaofeng Zhao
Xiaofeng Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240118263Abstract: Disclosed are target for screening anti-tumor drug, application use thereof and screening method therefor. Disclosed are a target for screening a drug for treating and/or preventing tumors, the target for screening the drug for treating and/or preventing tumors comprise selenoprotein; and a target for screening a drug for preventing tumor metastasis, the target for screening the drug for preventing the tumor metastasis comprising selenoprotein. Also disclosed is a method for screening a drug for treating and/or preventing tumors or a drug for preventing tumor metastasis, the method comprising: interacting a candidate drug with the selenoprotein; and screening the drug for treating and/or preventing tumors or the drug for preventing tumor metastasis according to an affinity between the candidate drug and the selenoprotein; and the candidate drug with a high affinity with the selenoprotein is taken as a candidate primarily screened drug.Type: ApplicationFiled: October 10, 2020Publication date: April 11, 2024Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Enhong JIANG, Weiqing HE, Mingyu XIA, Dong WANG, Xundong JIANG, Xiaofeng ZHAO
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Publication number: 20240114760Abstract: The invention provides a close space annealing method and a method for preparing a perovskite film or a solar cell. The method includes: placing a substrate coated with the perovskite precursor film on a hot plate, the hot plate being in direct contact with the back face of the substrate; controlling the evaporated amount and residual amount of the solvent in the perovskite precursor film by controlling the temperature of the hot plate and the heating duration, so that the perovskite materials are crystallized into perovskite grains to form a perovskite intermediate-phase film; placing the perovskite intermediate-phase film on the permeable membrane with the back face of the substrate facing upward, continuing with heating, so that adjacent perovskite grains merge with each other; and raising the temperature of the hot plate and continuing with heating so that the perovskite grains form a perovskite light-absorbing layer.Type: ApplicationFiled: December 6, 2023Publication date: April 4, 2024Inventors: Changlei WANG, Dewei ZHAO, Xiaofeng LI
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Publication number: 20240109974Abstract: Disclosed in the present invention are a humanized antibody that can specifically bind to TNFR2, or an antigen-binding fragment thereof. The humanized antibody or antigen-binding fragment thereof can regulate the function of immune cells and can be used in a drug for treating diseases related to immune abnormalities, such as tumours.Type: ApplicationFiled: January 27, 2022Publication date: April 4, 2024Applicant: SHANDONG SIMCERE BIOPHARMACEUTICAL CO., LTD.Inventors: Xiaofeng ZHAO, Shiqiang LU, Zhuoxiao CAO, Renhong TANG, Jinsheng REN
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Publication number: 20240092679Abstract: The present invention discloses a fabrication method and use of a ?40 mm large-size and high-contrast fiber optic image inverter, belonging to the field of manufacturing of fiber optic imaging elements. The light-absorbing glass for preparing the ?40 mm large-size and high-contrast fiber optic image inverter consists of the following components in molar percentage: SiO2 60-69.9, Al2O3 1.0-10.0, B2O3 10.1-15.0, Na2O 1.0-8.0, K2O 3.0-10.0, MgO 0.1-1.0, CaO 0.5-5.0, ZnO 0-0.1, TiO2 0-0.1, ZrO2 0.1-1.0, Fe2O3 3.0-6.5, Co2O3 0.1-0.5, V2O5 0.51-1.5 and MoO3 0.1-1.0. The fiber optic image inverter has the advantages of low crosstalk of stray light, high resolution and high contrast.Type: ApplicationFiled: July 20, 2023Publication date: March 21, 2024Inventors: Lei Zhang, Jinsheng Jia, Yue Zhao, Yu Shi, Huichao Xu, Haoyang Yu, Jing Zhang, Zhiheng Fan, Xian Zhang, Xiaofeng Tang, Puguang Song, Jiuwang Wang, Yun Wang, Yang Fu, Yajie Du, Yonggang Huang
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Publication number: 20240070182Abstract: Implementations of the present specification disclose an event risk detection method, apparatus, and device.Type: ApplicationFiled: August 28, 2023Publication date: February 29, 2024Inventors: Wenbiao ZHAO, Haotian WANG, Xiaofeng WU, Weiqiang WANG
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Publication number: 20230159971Abstract: The present disclosure provides a spiramycin-producing strain, a carrimycin-producing strain, construction method therefor, use thereof and method for increasing the product yield thereof. The provided spiramycin-producing strain has an inactivated gene Lrp (?lrp-SP); and the strain has a preservation number of CGMCC No.16056. The provided carrimycin-producing strain has an inactivated gene Lrp (?lrp-BT); and the strain has a preservation number of CGMCC No.16055. By inactivating the gene Lrp, the yields of spiramycin and carrimycin are increased; and particularly the yield and proportion of a major component of the carrimycin, that is, 4?-O-isovalerylspiramycin III are significantly increased.Type: ApplicationFiled: December 12, 2019Publication date: May 25, 2023Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Enhong JIANG, Weiqing HE, Xiaofeng ZHAO, Xunlei JIANG
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ROTATION SHAFT MECHANISM FOR FOLDABLE SCREEN, FOLDABLE SCREEN ASSEMBLY, AND FOLDABLE MOBILE TERMINAL
Publication number: 20220311847Abstract: The present application provides a rotation shaft mechanism for a foldable screen, a foldable screen assembly, and a foldable mobile terminal. The present application can make the foldable screen of the foldable terminal work more reliably and smoothly. It has outstanding advantages of simpler structure, easy implementation, low cost, strong reliability, long lifespan, and more application fields, and can be widely used in foldable mobile terminals.Type: ApplicationFiled: December 12, 2019Publication date: September 29, 2022Applicant: HuiZhou TCL Mobile Communication Co., Ltd.Inventors: Xiaofeng ZHAO, Yongqiu XIE -
Patent number: 11413302Abstract: A medicament for preventing and/or treating a disease is disclosed, the disease is Alzheimer's disease, diabetes or senility; and the medicament includes a first active ingredient, and the first active ingredient includes one of carrimycin, isovalerylspiramycin I, isovalerylspiramycin II and isovalerylspiramycin III, or a combination of two or three of isovalerylspiramycin I, isovalerylspiramycin II and isovalerylspiramycin III.Type: GrantFiled: January 18, 2019Date of Patent: August 16, 2022Assignee: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Mingyu Xia, Xiaofeng Zhao, Xunlei Jiang, Xundong Jiang
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Publication number: 20220135489Abstract: The present disclosure discloses a method for preparing a continuous fiber-reinforced ceramic matrix composite by flash sintering technology, including: placing a continuous ceramic fiber preform in a mold, adding a nano-ceramic powder, and subjecting the resultant to mechanical oscillation and press forming in sequence to obtain a green body; heating the green body to a preset temperature and applying an electric field with a preset electric field intensity, until occurrence of flash sintering; and converting a power supply from a constant voltage state to a constant current state, holding at the temperature and cooling to obtain the continuous fiber-reinforced ceramic matrix composite.Type: ApplicationFiled: October 25, 2021Publication date: May 5, 2022Applicant: SHANGHAI JIAO TONG UNIVERSITYInventors: Juan Jiang, Na Ni, Xiaofeng Zhao, Qi Ding, Weiwei Xiao, Yinchun Shi
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Patent number: 11315959Abstract: The present disclosure provides an array substrate and a display panel. The array substrate includes a wiring layer, and a non-wiring layer located on a bottom portion of the wiring layer. The non-wiring layer includes a first film layer and a second film layer, which are sequentially stacked in a direction away from the wiring layer. A refractive index of the second film layer is smaller than a refractive index of the first film layer.Type: GrantFiled: January 8, 2020Date of Patent: April 26, 2022Assignee: WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.Inventor: Xiaofeng Zhao
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Publication number: 20220017630Abstract: An antibody or an antigen-binding fragment thereof capable of specifically binding to TNFR2, the antibody or the antigen-binding fragment thereof is capable of regulating the function of immune cells and may be used as a medicament to treat diseases related to immune-related disorders, such as tumors.Type: ApplicationFiled: July 31, 2020Publication date: January 20, 2022Inventors: Xinyan ZHAO, Xiaofeng ZHAO, Shiqiang LU, Ran PANG, Xinxin LI, Jinsheng REN
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Publication number: 20210408079Abstract: The present disclosure provides an array substrate and a display panel. The array substrate includes a wiring layer, and a non-wiring layer located on a bottom portion of the wiring layer. The non-wiring layer includes a first film layer and a second film layer, which are sequentially stacked in a direction away from the wiring layer. A refractive index of the second film layer is smaller than a refractive index of the first film layer.Type: ApplicationFiled: January 8, 2020Publication date: December 30, 2021Inventor: Xiaofeng ZHAO
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Patent number: 11180419Abstract: A method for the preparation of a dense HfC(Si)—HfB2 composite ceramic. hafnium oxide powders, nano-sized carbon black and silicon hexaboride powders are mixed in a molar ratio of (1-10):(1-20):(1-5) to obtain a powder mixture. The powder mixture is subjected to ball milling, dried and transferred to a graphite mold for spark plasma sintering. In this way, an in-situ carbon-boron reduction reaction and the sintering densification are completed in one step, and the obtained HfC(Si)—HfB2 composite ceramic has a density of 94.0%-100% and uniformly dispersed grains.Type: GrantFiled: February 26, 2021Date of Patent: November 23, 2021Assignee: SHANGHAI JIAO TONG UNIVERSITYInventors: Wei Hao, Xiaofeng Zhao, Na Ni, Huangyue Cai, Yao Yao, Meiyu Yi, Fangwei Guo
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Patent number: 11049710Abstract: The present application relates to an ion transmission device, more particularly, to a device and method for generating, storing and transmitting positive and negative ions. The device includes a wire electrode, a perforated insulating board, a tensioning device, an axial field electrode and an ion source for providing ions. The generated positive and negative ions are respectively stored on two ends of a cavity by the device; and the positive or negative ions are led out as needed. The utilization efficiency of positive and negative ions, as well as sensitivity, are greatly improved by the device.Type: GrantFiled: November 6, 2019Date of Patent: June 29, 2021Inventor: Xiaofeng Zhao
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Publication number: 20210187324Abstract: A position monitoring system is provided. The position monitoring system includes: a first support, configured to be movably connected to a patient supporting device; at least one first marking component, disposed at a portion to be treated of a patient; at least one second marking component, disposed at a preset position; a movement monitoring device, disposed on the first support and configured to monitor a displacement of the first marking component relative to the second marking component; and a control device, connected to the movement monitoring device and configured to determine whether a position of the portion to be treated of the patient is moved according to the displacement monitored by the movement monitoring device.Type: ApplicationFiled: September 5, 2018Publication date: June 24, 2021Inventor: Xiaofeng ZHAO
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Publication number: 20210179499Abstract: A method for the preparation of a dense HfC(Si)—HfB2 composite ceramic. hafnium oxide powders, nano-sized carbon black and silicon hexaboride powders are mixed in a molar ratio of (1-10):(1-20):(1-5) to obtain a powder mixture. The powder mixture is subjected to ball milling, dried and transferred to a graphite mold for spark plasma sintering. In this way, an in-situ carbon-boron reduction reaction and the sintering densification are completed in one step, and the obtained HfC(Si)—HfB2 composite ceramic has a density of 94.0%-100% and uniformly dispersed grains.Type: ApplicationFiled: February 26, 2021Publication date: June 17, 2021Inventors: Wei HAO, Xiaofeng ZHAO, Na NI, Huangyue CAI, Yao YAO, Meiyu YI, Fangwei GUO
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Patent number: 11000708Abstract: Use of carrimycin in Mycobacterium tuberculosis infection resistance comprises the main steps: measuring the activity of carrimycin in Mycobacterium tuberculosis resistance by adopting an absolute concentration method through taking clinical first-line antituberculotics, i.e., isoniazid and rifampicin as controls. The result indicates that carrimycin has obvious superior activity to clinically-separated Mycobacterium tuberculosis including drug-resistant bacteria compared with those of the clinical first-line control drugs, i.e., the isoniazid and the rifampicin, and use of carrimycin in manufacturing drugs for treating tubercle Bacillus infected diseases are expected to be developed.Type: GrantFiled: December 5, 2016Date of Patent: May 11, 2021Assignee: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Yiguang Wang, Yang Jiang, Xiaofeng Zhao, Weiqing He
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Patent number: 10952335Abstract: The present application discloses a flexible display panel and a display device, including a first edge and a second edge perpendicular to each other, and a first display unit and a second display unit symmetrical to each other. The first display unit is not parallel to the first edge at a preset angle and is connected to the second display unit by signal wires. The signal wires include a first line, a second line, and a third line. The first line is connected to the first display unit and is parallel to the first display unit. The second line is connected to the second display unit and is parallel to the second display unit. Two ends of the third line are respectively connected to the first line and the second line in a zigzag shape. Bending resistance of the flexible display panel of the present application is increased.Type: GrantFiled: April 16, 2020Date of Patent: March 16, 2021Assignee: WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.Inventor: Xiaofeng Zhao
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Publication number: 20200405739Abstract: Disclosed are an mTOR inhibitor, a pharmaceutical composition and use thereof. The mTOR inhibitor includes one of carrimycin, isovalerylspiramycin I, isovalerylspiramycin II and isovalerylspiramycin III, or a combination of two or three of isovalerylspiramycin I, isovalerylspiramycin II and isovalerylspiramycin III. The pharmaceutical composition also includes a drug for treating and/or preventing diseases related to the mTOR pathway as a second active ingredient. The mTOR inhibitor has obvious inhibiting effect on cells of diseases related to mTOR pathway, and is used for preparing drugs for treating and/or preventing diseases related to the mTOR pathway.Type: ApplicationFiled: January 18, 2019Publication date: December 31, 2020Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Mingyu XIA, Xiaofeng ZHAO, Xunlei JIANG, Xundong JIANG
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Patent number: 10858659Abstract: The present disclosure provides a biosynthetic gene cluster of carrimycin. The biosynthetic gene cluster comprises 44 gene open reading frames (orf), i.e., 5 orfs (orf10-14) encoding polyketide synthase, 9 orfs (orf1, 4-6, 15 and 36-39) related to polyketone synthesis extension unit and modification, 16 orfs (orf9, 16-22, 24, 26, 28, 29, 33-35 and 41) related to glycosyl synthesis, 6 orfs (orf7, 8, 30-32 and 40) related to glycosyl transfer, 2 orfs (orf3 and 25) related to resistance, 4 orfs (orf2, 23, 27 and 42) possibly related to regulation, a tsr resistance marker gene orf (orf43) and a 4?-mycaroseglucoside isovaleryl transferase gene orf (orf44).Type: GrantFiled: November 24, 2016Date of Patent: December 8, 2020Assignee: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Yiguang Wang, Yang Jiang, Xiaofeng Zhao, Weiqing He, Jianlu Dai