Patents by Inventor Xiao-Jin Xu

Xiao-Jin Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Galactose-alpha-1, 3-galactose-containing n-glycans in glycoprotein products derived from CHO cells
    Patent number: 10023894
    Abstract: Methods of producing recombinant therapeutic fusion proteins described herein can include culturing Chinese hamster ovary (CHO) cells under conditions suitable for expression of a recombinant therapeutic fusion protein including one or more glycans, where the CHO cells have not been genetically engineered to produce terminal alpha-galactosyl residues on glycans; treating the one or more glycans of the recombinant glycoprotein with one or more exoglycosidases; measuring glycans containing terminal galactose-alpha-1-3-galactose residues on the fusion protein by nuclear magnetic resonance (NMR); and producing a recombinant therapeutic fusion protein in the CHO cells if a target level of terminal galactose-alpha-1-3-galactose residues is measured.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: July 17, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • GALACTOSE-ALPHA-1, 3-GALACTOSE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20160053292
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: August 21, 2015
    Publication date: February 25, 2016
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • Evaluation of copolymer diethylamide
    Patent number: 8765911
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 1, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • Evaluation of copolymer diethylamide
    Patent number: 8759484
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 24, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • Characterization of -linked glycans
    Patent number: 8729241
    Abstract: The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: May 20, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Xiao-Jin Xu, Shiming Dong, Guy Dellorusso
  • GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20140045212
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • EVALUATION OF COPOLYMER DIETHYLAMIDE
    Publication number: 20140046024
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Application
    Filed: December 3, 2012
    Publication date: February 13, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • EVALUATION OF COPOLYMER DIETHYLAMIDE
    Publication number: 20140045204
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Application
    Filed: September 6, 2013
    Publication date: February 13, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • Gal ?1-3gal-containing N-glycans in glycoprotein products derived from CHO cells
    Patent number: 8586356
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: November 19, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • Evaluation of copolymer diethylamide
    Patent number: 8324348
    Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: December 4, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
  • CHARACTERIZATION OF O-LINKED GLYCANS
    Publication number: 20110287465
    Abstract: The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein.
    Type: Application
    Filed: December 18, 2009
    Publication date: November 24, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Cuihua Liu, Xiao-Jin Xu, Shiming Dong, Guy Dellorusso
  • ANTENNARY FUCOSYLATION IN GLYCOPROTEINS FROM CHO CELLS
    Publication number: 20110136682
    Abstract: The present invention provides methods of evaluating CHO cells and producing recombinant glycoproteins.
    Type: Application
    Filed: December 3, 2010
    Publication date: June 9, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Carlos J. Bosques, Cuihua Liu, Jennifer Murphy, Nathaniel J. Washburn, Xiao-Jin Xu
  • GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20110045496
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: January 22, 2009
    Publication date: February 24, 2011
    Inventors: Carlos Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu