Patents by Inventor Xiaojun Peng

Xiaojun Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240041787
    Abstract: A photosensitizer molecule increases the retention time thereof in a tumor and the enhancement of the therapy for large-volume tumors. AN-BDP is synthesized by means of introducing anthracene into BODIPY-meso, and due to the strong intermolecular ?-? interaction of anthracene, AN-BDP and an amphiphilic block copolymer DSPE-PEG2000 are self-assembled into stable nanoparticles AN-BDP NPs. By means of anthracene, AN-BDP can be excited to a triplet excited state under light irradiation and acts with O2 to generate 1O2. AN-BDP NPs are enriched at the tumor site and retained for about 10 days after tail vein injection. In a mouse tumor model having a conventional volume tumor, AN-BDP NPs can completely inhibit the growth of the tumor by means of one-time tail vein injection and one-time photoirradiation therapy.
    Type: Application
    Filed: September 26, 2022
    Publication date: February 8, 2024
    Inventors: Wen SUN, Dongmei XI, Xiaojun PENG, Jiangli FAN
  • Patent number: 11639360
    Abstract: Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: May 2, 2023
    Assignees: DALIAN UNIVERSITY OF TECHNOLOGY, DALIAN CHROMAS BIOSCIENCE CO., LTD
    Inventors: Jiangli Fan, Qichao Yao, Haidong Li, Yana Bian, Mingle Li, Jingyun Wang, Xiaojun Peng
  • Patent number: 11504428
    Abstract: A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: November 22, 2022
    Assignees: DALIAN UNIVERSITY OF TECHNOLOGY, DALIAN CHROMAS BIOSCTENCE CO., LTD
    Inventors: Xiaojun Peng, Mingle Li, Jiangli Fan, Qichao Yao, Jianjun Du, Saran Long, Jingyun Wang
  • Patent number: 11217906
    Abstract: This application provides a CPE device that includes: a housing, an omnidirectional antenna, a communications module, a PCB, and a heat sink. The omnidirectional antenna is connected to an input end of the communications module, an output end of the communications module is connected to the PCB. An output end of the PCB is connected to an Ethernet cable, and the PCB is disposed on the heat sink. The communications module is configured to convert a received radio-frequency signal to a digital signal. The housing is a cylindrical structure with an opening formed at a lower end. The omnidirectional antenna, the communications module, and the PCB are disposed inside the housing. The heat sink is disposed at the lower end of the housing, and a through hole for the Ethernet cable to pass through is disposed on the heat sink.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: January 4, 2022
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Feng Gao, Xiaoliang Wang, Wei Chen, Xiaojun Peng
  • Publication number: 20210188875
    Abstract: Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.
    Type: Application
    Filed: April 22, 2019
    Publication date: June 24, 2021
    Inventors: Jiangli FAN, Qichao YAO, Haidong LI, Yana BIAN, Mingle LI, Jingyun WANG, Xiaojun PENG
  • Publication number: 20210030873
    Abstract: A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues.
    Type: Application
    Filed: November 24, 2017
    Publication date: February 4, 2021
    Applicants: DALIAN UNIVERSITY OF TECHNOLOGY, DALIAN CHROMAS BIOSCIENCE CO., LTD
    Inventors: Xiaojun PENG, Mingle LI, Jiangli FAN, Qichao YAO, Jianjun DU, Saran LONG, Jingyun WANG
  • Patent number: 10825608
    Abstract: A method for manufacturing a magnetic coil in a wireless charging system is disclosed. The coil may comprise a wire with a rectangular cross section. The method may include feeding a wire into a routing device which includes three winding wheels; routing the wire into a magnetic coil by changing positions of the winding wheels; and assembling the magnetic coil by pressing and attaching the magnetic coil to a coil holder.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: November 3, 2020
    Assignee: Shenzhen Yichong Wireless Power Technology Co. Ltd
    Inventors: Xiaojun Peng, Dezheng Pan, Changzheng Liu, Siming Pan, Tun Li, Dawei He
  • Publication number: 20200235496
    Abstract: This application provides a CPE device that includes: a housing, an omnidirectional antenna, a communications module, a PCB, and a heat sink. The omnidirectional antenna is connected to an input end of the communications module, an output end of the communications module is connected to the PCB. An output end of the PCB is connected to an Ethernet cable, and the PCB is disposed on the heat sink. The communications module is configured to convert a received radio-frequency signal to a digital signal. The housing is a cylindrical structure with an opening formed at a lower end. The omnidirectional antenna, the communications module, and the PCB are disposed inside the housing. The heat sink is disposed at the lower end of the housing, and a through hole for the Ethernet cable to pass through is disposed on the heat sink.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 23, 2020
    Inventors: Feng GAO, Xiaoliang WANG, Wei CHEN, Xiaojun PENG
  • Publication number: 20180294096
    Abstract: A method for manufacturing a magnetic coil in a wireless charging system is disclosed. The coil may comprise a wire with a rectangular cross section. The method may include feeding a wire into a routing device which includes three winding wheels; routing the wire into a magnetic coil by changing positions of the winding wheels; and assembling the magnetic coil by pressing and attaching the magnetic coil to a coil holder.
    Type: Application
    Filed: September 8, 2017
    Publication date: October 11, 2018
    Inventors: Xiaojun PENG, Dezheng PAN, Changzheng LIU, Siming PAN, Tun LI, Dawei HE
  • Publication number: 20180269710
    Abstract: A design of a power transmitter coil for a wireless charging system is disclosed. The power transmitter coil may include a square-shaped coil and two terminals. The two terminals may be extended from the coil. The coil may be routed by a wire in a plane.
    Type: Application
    Filed: April 18, 2017
    Publication date: September 20, 2018
    Inventors: Xiaojun Peng, Siming Pan, Tun Li, Dawei He
  • Patent number: 10029996
    Abstract: The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: July 24, 2018
    Assignee: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Xiaojun Peng, Si Zhang, Jiangli Fan, Jingyun Wang
  • Patent number: 9862731
    Abstract: The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2?, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 9, 2018
    Assignee: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Jiangli Fan, Hao Zhu, Xiaojun Peng, Jingyun Wang
  • Publication number: 20170029444
    Abstract: The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2?, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.
    Type: Application
    Filed: November 26, 2014
    Publication date: February 2, 2017
    Inventors: Jiangli FAN, Hao ZHU, Xiaojun PENG, Jingyun WANG
  • Patent number: 9182350
    Abstract: The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: November 10, 2015
    Assignees: DALIAN UNIVERSITY OF TECHNOLOGY, DALIAN CHROMAS BIOSCIENCE CO., LTD.
    Inventors: Xiaojun Peng, Hua Zhang, Jiangli Fan, Jingyun Wang
  • Publication number: 20150118703
    Abstract: The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.
    Type: Application
    Filed: September 15, 2014
    Publication date: April 30, 2015
    Inventors: Xiaojun PENG, SI ZHANG, JIANGLI FAN, JINGYUN WANG
  • Patent number: 9011589
    Abstract: The present invention relates to a class of magenta dyes, their preparation methods and applications. The magenta dyes include the compounds which simultaneously contain carboxyl group, sulfonic acid group and the carbonyl propyl sulfurylsulfonic acid on the anthrapyridone skeleton, showing in the form of general formula (I) or their mixtures. In the general formula (I): A may be cation M4, or substituted or unsubstituted benzyl group, or substituted or unsubstituted naphthyl methyl; M1, M2, M3 are respectively cation or cationic groups; Sulfonic acid group (SO3M2)m may located any position of the benzene ring, of which m is an integer of 0-2. As containing carboxyl (or carboxylic benzyl ester or naphthoate), sulfonic acid groups and carbonyl propyl sulfuryl simultaneously, the magenta dyes of the present invention feature outstanding tone, brightness, light resistance, water resistance, ozone resistance as well as solubility and solution stability, etc.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 21, 2015
    Assignees: Dalian University of Technology, Zhuhai Ninestar Management Co., Ltd.
    Inventors: Xiaojun Peng, Shiyu Li, Jinhe Wu, Fanming Meng, Rong Zhang, Jiangli Fan, Feng Wang, Shaolei Li
  • Publication number: 20150079625
    Abstract: The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.
    Type: Application
    Filed: March 5, 2012
    Publication date: March 19, 2015
    Applicants: DALIAN CHROMAS BIOSCIENCE CO., LTD, DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Xiaojun Peng, Hua Zhang, Jiangli Fan, Jingyun Wang
  • Patent number: 8968453
    Abstract: The present invention relates to a class of compounds of general formula (I) or their salts of general formula (II): In formula (I)-(II), the substituents (A)p and (SO3H)n on the benzene ring are at the ortho, meta or para position, n is 0-2, and p is 0-3; M is selected from Li+, Na+, K+, NH4+ or organic ammonium salt N+R1R2R3R4, where R1, R2, R3, R4 are the same or different H, C1-18 alkyl groups, cyclohexyl groups, CH2CH2OH, CH(CH3)CH2OH or benzyl groups; where p>0, A stands for the same or different groups selected from: H, CN, NO2, NH2, F, Cl, Br, C1-18 alkyl group, cyclohexyl group, phenyl group, benzyl group, phenoxy group, C1-18 alkoxy group, C1-18 alkylthio group, SO2CH?CH2, SO2CH2CH2A1, NR6COR5 or NR6SO2R5.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: March 3, 2015
    Assignees: Zhuhai Ninestar Management Co., Ltd., Dalian University of Technology
    Inventors: Xiaojun Peng, Tao Liu, Jinhe Wu, Rong Zhang, Jingyue Wang, Feng Wang, Shaolei Li, Jianzhou Zhang, Zhengru Yang
  • Patent number: 8962339
    Abstract: The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2+ in near-neutral pH range. In detection of Pd2+ in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2+ in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2+ concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: February 24, 2015
    Assignees: Dalian University of Technology, Dalian Chromas Bioscience Co., Ltd.
    Inventors: Xiaojun Peng, Jiangli Fan, Honglin Li, Jingyun Wang, Shiguo Sun
  • Patent number: 8889887
    Abstract: A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCR3R4; R1 and R2 are independently selected from the group consisting of (CH2)nR7 and et al.; R3 and R4 are independently selected from the group consisting of CN, COOH and COOR16; R5, R6 and R7 are independently selected from the group consisting of H, SO3R10 and COOR11; R8 is H or C1-18 alkyl; R9 is H or CH3; R10 is N(R12R13R14R15); R11 is C1-18 alkyl; R12, R13, R14, R15 and R16 are independently selected from the group consisting of H, C1-18 alkyl, (CH2)mOR8 and (CHR9CH2O)pR8; Y? is halogen anion or OTs?; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: November 18, 2014
    Assignees: Dalian University of Technology, Dalian Firstar Information Materials Co., Ltd.
    Inventors: Xiaojun Peng, Zhigang Yang, Yanxia He, Jingyun Wang, Jiangli Fan, Shiguo Sun, Fengling Song