Patents by Inventor Xiao Mo

Xiao Mo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF MICROORGANISMS USING MALDI-TOF-MS ON-PLATE EXTRACTION
    Publication number: 20220170065
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Application
    Filed: November 8, 2021
    Publication date: June 2, 2022
    Applicant: BECTON DICKINSON AND COMPANY
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo
  • Identification of microorganisms using MALDI-TOF-MS on-plate extraction
    Patent number: 11193158
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: December 7, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo
  • IDENTIFICATION OF MICROORGANISMS USING MALDI-TOF-MS ON-PLATE EXTRACTION
    Publication number: 20200149085
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Application
    Filed: January 6, 2020
    Publication date: May 14, 2020
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo
  • Identification of microorganisms using MALDI-TOF-MS on-plate extraction
    Patent number: 10557162
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: February 11, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo
  • IDENTIFICATION OF MICROORGANISMS USING MALDI-TOF-MS ON-PLATE EXTRACTION
    Publication number: 20170204448
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Application
    Filed: March 29, 2017
    Publication date: July 20, 2017
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo, Mary R. Votta, Ben Turng, Donald R. Callihan, Wendy Louise Williams
  • Identification of microorganisms using MALDI-TOF-MS on-plate extraction
    Patent number: 9631221
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: April 25, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien Malick, Jon E. Salomon, John D. Mantlo
  • COMPOSITIONS COMPRISING MODIFIED COLLAGEN AND USES THEREFOR
    Publication number: 20150111308
    Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.
    Type: Application
    Filed: October 13, 2014
    Publication date: April 23, 2015
    Inventors: Michael Yu, Jennifer H. Elisseeff, Hyeseung Janice Lee, Xiao Mo, Allen Yi-Lan Wang
  • Compositions comprising modified collagen and uses therefor
    Patent number: 8883964
    Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: November 11, 2014
    Assignee: The Johns Hopkins University
    Inventors: Michael Yu, Jennifer H. Elisseeff, Allen Yi-Lan Wang, Hyeseung Janice Lee, Xiao Mo
  • COMPOSITIONS COMPRISING MODIFIED COLLAGEN AND USES THEREFOR
    Publication number: 20130116405
    Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.
    Type: Application
    Filed: September 6, 2012
    Publication date: May 9, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Michael Yu, Jennifer H. Elisseeff, Allen Y. Wang, Hyeseung J. Lee, Xiao Mo
  • Compositions comprising modified collagen and uses therefor
    Patent number: 8283414
    Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: October 9, 2012
    Assignee: The Johns Hopkins University
    Inventors: Michael Yu, Jennifer H. Elisseeff, Hyeseung Janice Lee, Xiao Mo, Allen Yi-Lan Wang
  • Compositions Comprising Modified Collagen and Uses Therefor
    Publication number: 20080287342
    Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.
    Type: Application
    Filed: November 23, 2005
    Publication date: November 20, 2008
    Applicant: The Johns Hopkins University
    Inventors: Michael Yu, Jennifer H. Elisseeff, Allen Y. Wang, Hyeseung J. Lee, Xiao Mo
  • Separator
    Publication number: 20070132172
    Abstract: Various embodiments of a separator are disclosed.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 14, 2007
    Inventor: Jiang-Xiao Mo
  • Torque source
    Publication number: 20070052165
    Abstract: Various apparatus and methods are disclosed for providing torque.
    Type: Application
    Filed: September 2, 2005
    Publication date: March 8, 2007
    Inventor: Jiang-Xiao Mo