Abstract: Provided is a catenated VAR2CSA recombinant protein, a preparation therefor and a use thereof. The catenated VAR2CSA recombinant protein comprises a binding domain, SpyTag, a p53dim structural domain, and SpyCatcher, which are randomly arranged. The binding domain comprises a structural domain, in the VAR2CSA protein, binding to placenta-like chondroitin sulfate A. The catenated VAR2CSA recombinant protein has high stability and affinity to the tumor-specific antigen placenta-like chondroitin sulfate A, and can be effectively used in the field of tumor immunotherapy, such as immune cell therapy.

Abstract: Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.

Abstract: Provided are the use of Plasmodium in the preparation of an anti-tumor preparation for use in combination with radiotherapy and a Plasmodium anti-tumor preparation for use in combination with radiotherapy.

Abstract: Disclosed are a decoquinate liposome, a preparation method therefor and a use thereof. The preparation raw materials for the decoquinate liposome comprise the following components in parts by weight: 1 part of decoquinate and 2-20 parts of lecithin. The liposome is stable, shows favorable malaria resistance effects in-vivo and in-vitro with respect to animal bodies, can be used for quickly relieving the conditions of malaria, particularly subtertian malaria, and is safe. The preparation method is simple and feasible, and has the potential for mass production.

Abstract: The invention relates to a planting method of DendrobiumnobileLindl, it comprises the following steps: Selecting betel palm trees that are more than 5 years old or or more than 6 meters high; Selecting the DendrobiumnobileLindl seedlings with a height of more than 12 cm, with 1 or 2 new buds and complete roots, stems and leaves, and dividing DendrobiumnobileLindl seedlings into 2-4 clumps a group; Combing and aligning the roots of each group of DendrobiumnobileLindlseedlings, taking one group of DendrobiumnobileLindl seedlings and sticking them to the knot of the betel plain tree each time, then using a cotton rope or a tie to wind and fix the DendrobiumnobileLindl seedlings on the betel palm tree trunk from the stems of each group of DendrobiumnobileLindl seedlings; Putting the roots below the stembase of the DendrobiumnobileLindlseedling on the betel palm tree trunk and smearingdendrobium nutrient.

Abstract: The application discloses a method for replacing seedbed culture substrate and a conveyor belt seedbed, the flatbed truck is used to receive the dropped culture substrate at the end of the conveyor belt that has been driven all the time, without manual removal by workers. The conveyor belt continues to drive until the flatbed truck is fully loaded or only when the culture substrate on the conveyor belt is emptied, only need to place the flatbed truck full of culture substrate at the head end of the conveyor belt when placing new culture substrate, and turn on the conveyor belt, which speeds up the efficiency of replacing the culture substrate, and this method only requires one person can complete the replacement of the culture substrate on the seedbed, which solves the technical problem that the existing method of replacing the culture substrate is to manually remove the culture substrate on the seedbed, which leads to the long time for replacing the culture substrate and low work efficiency.

Abstract: The invention relates to an electric seedling greenhouse, The illumination intensity in the seedling greenhouse is detected by the illumination transmitter, the light intensity information in the seedling greenhouse is transmitted to the information processing module, the light intensity preset value required by plants is set in the information processing module, the shading rate of the first sunshade device is not equal to the shading rate of the second sunshade device, when the light intensity is higher than the preset value, the light intensity collected by the illuminance transmitter is transmitted to the information processing module, and it is judged to meet the value of starting sunshade device, then analyze the light intensity to automatically select the corresponding shading rate of the sunshade device to open and complete the shading.

Abstract: This application provides a dendrobium watering method and system, by way of imitation of wild cultivation of dendrobium on volcano, first on the volcano cant selection from the top 15 to 25 cm line code position, use a hard masonry nail line code insert to spray rod fixed to the fixed position of the line of code. The ground lance G-shaped nozzle is higher than the top of the volcano.

Abstract: A processing method of Dendrobium organic fertilizer, which comprises the following steps: Step 1: select 4-6 parts by weight of rotten animal dung; Step 2: add 0.5-1.5 parts by weight of disinfectant to animal dung; Step 3: add disinfectant to dung and let it stand for 1-3 hours; Step 4. uniformly mixing to obtain organic fertilizer. The invention controls the viscosity of animal dung within a range, thereby improving the adhesion between animal dung and Dendrobium, slowing down the drying and hardening speed of animal dung, moisturizing the roots, sterilizing animal dung and reducing the probability of affecting the growth of Dendrobium.

Abstract: The present invention relates to a novel compound (formula I), which has cancer treatment activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition containing the compound.

Abstract: The present invention provides crystals of a quaternary ammonium salt structure compound, i.e., (2R,3R)-3-[(2-cyclopentyl-2-hydroxy-2-phenyl)ethoxy]-1-(3-phenoxypropyl) azabicyclo[2,2,2]octylonium bromide (Compound I). A Type-A crystal of Compound I displays diffraction peaks at the following diffraction angles 2? in a X-ray powder diffraction pattern thereof: 5.7±0.2 degrees, 12.9±0.2 degrees, 16.7±0.2 degrees, 18.0±0.2 degrees, 19.5±0.2 degrees, 21.1±0.2 degrees, 22.3±0.2 degrees and 23.3±0.2 degrees. A Type-B crystal of Compound I displays diffraction peaks at the following diffraction angles 2? in a X-ray powder diffraction pattern thereof: 5.2±0.2 degrees, 15.8±0.2 degrees, 16.9±0.2 degrees, 17.7±0.2 degrees, 19.5±0.2 degrees, 20.2±0.2 degrees and 22.1±0.2 degrees. The present application also relates to a new method for preparing Compound I and applications of the two novel crystals in the field of medicine.

Abstract: A drug for preventing and/or treating a brain tumor and an application thereof. The drug comprises Plasmodium. The drug has significant preventive and/or therapeutic effects on a brain tumor, and is capable of inhibiting the growth of the brain tumor and prolonging the life span of a patient, and has no obvious side effects and has a high safety level. The drug expands treatment methods for brain tumors. Due to the specificity and sensitivity of brain tissues, chemotherapeutic drugs cannot easily cross the blood-brain barrier and exert anti-tumor effects. The drug mainly regulates the immunological functions and inflammation-related factors of the body to break through the blood-brain barrier by fully activating immunocompetence and inhibiting the growth of a brain tumor, thereby extending lifespan.

Abstract: Hot-melt extrusion for producing solid solution comprising nanoparticle formulation of decoquinate is disclosed. Aqueous phase comprising the nanoparticles of hot-melt extruding products is homogeneous and stable. Provided is the composition comprising the solid solution of decoquinate and a method of hot-melt extrusion for producing this composition comprising the solid dispersion of decoquinate. Furthermore, provided is the solid solution comprising nanosized decoquinate formulation having improved water solubility and enhanced delivery of decoquinate in digestive system for absorption, increasing bioavailability, and the efficacy against malaria at the liver stage.

Abstract: Provided are compounds of formula (I), which have KRAS mutation tumor regulating activity. Also provided are a method for providing these compounds and a pharmaceutical composition comprising the same.

Abstract: Disclosed are an attenuation system and the use thereof for attenuating plasmodia, specifically the use of an EF1g gene for attenuating plasmodia. The attenuation system regulates the expression or degradation of the EF1g gene by using a regulatory system, thereby controlling the growth of plasmodia and achieving the attenuation of plasmodia.

Abstract: The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a ?2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Abstract: An anti-neoplastic combined pharmaceutical composition and application thereof. The combined pharmaceutical composition is prepared from plasmodia and chemotherapeutic drugs. The combined pharmaceutical composition combines chemotherapy with Plasmodium immunotherapy, has high biosafety, has stronger antineoplastic activity than single chemotherapy or single Plasmodium immunotherapy, can prolong the lifetime of cancer patients, and provides a new strategy and idea for cancer treatment. Moreover, the dosage of the chemotherapy drugs can be reduced, toxic and side effects caused by the chemotherapy drugs are reduced, and treatment costs of tumor patients are reduced. In addition, the combined pharmaceutical composition can promote release of a tumor antigen, induces a stronger anti-tumor specific immune response, and exerts the continuous synergistic effect of immunotherapy and chemotherapy.

Abstract: Disclosed are a combined formulation kit for analyzing the phenotype and function of a CD1c+ dendritic cell subset and the use thereof, wherein the detection objects of the kit include CD1c, CD40, IL-6 and IL-10. The kit can be used to efficiently and quickly identify the phenotype of a CD1c+ dendritic cell subset in peripheral blood and analyze the function thereof, thereby ensuring accuracy and reducing the economic cost produced by detecting a large number of surface antigen molecules, and the detection method is also simple to implement.