Patents by Inventor Xiao Ping Zhou

Xiao Ping Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200093832
    Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 26, 2020
    Inventors: Kun Ping LU, Matthew Brian Boxer, Mindy Irene Emily Davis, Rajan Pragani, Min Shen, Anton Momtchilov Simeonov, Shuo Wei, Xiao Zhen Zhou
  • Patent number: 10548864
    Abstract: The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: February 4, 2020
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Xiao Zhen Zhou, Shuo Wei, Lijun Sun, Michelle Lynn Hall
  • Patent number: 10485780
    Abstract: The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: November 26, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Shuo Wei, Xiao Zhen Zhou
  • Patent number: 10487114
    Abstract: The present invention features methods and compositions for the generation of conformation-specific antibodies.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: November 26, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Xiao Zhen Zhou
  • Patent number: 10413548
    Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: September 17, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Kun Ping Lu, Matthew Brian Boxer, Mindy Irene Emily Davis, Rajan Pragani, Min Shen, Anton Momtchilov Simeonov, Shuo Wei, Xiao Zhen Zhou
  • Patent number: 10351914
    Abstract: Biomarkers and driver mutations for diagnosis and prognosis of Pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of Pin 1-associated diseases may include detecting the level of Pin1 to stage abnormal cell growth, such as breast or prostate cancer. In another embodiment, the methods include evaluating the efficacy of a treatment of abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the methods include using driver mutations to determine the pharmacogenetics of abnormal cell growth, such as cancer. In the present disclosure, elevated active monomeric Pin1 levels may be detected by Pin1 biomarkers, which may include Pin1 Q33K or E100D driver mutations, Pin1 protein or transcript overexpression, dephosphorylation of Pin1 on Ser71, dephosphorylation of S16, phosphorylation of S65, phosphorylation of S138, deacetylation of Pin1 on K13 and deacetylation of K46, and/or desumoylation of Pin1 on K6 and desumolation of K63, among others.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: July 16, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Xiao Zhen Zhou, Shuo Wei
  • Patent number: 9281516
    Abstract: A cathode material of a lithium ion secondary battery is provided, which includes a cathode active material and a glassy material coating on a surface of the cathode active material. The glassy material is capable of selectively allowing lithium ions to pass therethrough. The lithium ion secondary battery using the cathode material has the long cycle life and the high safety performance.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: March 8, 2016
    Assignee: MICROVAST POWER SYSTEMS CO., LTD.
    Inventor: Xiao-Ping Zhou
  • Patent number: 8748335
    Abstract: A photodegradation catalyst or a photodegradation catalyst precursor comprises a plurality of domains of an oxide of a first metal distributed in a substrate of a halide or oxyhalide of a second metal, wherein the mole percentage of the halide or oxyhalide of the second metal is above 50%. Additionally, a method of preparing a photodegradation catalyst or a photodegradation catalyst precursor, a photodegradation catalyst or a photodegradation catalyst precursor obtained from the method and a method of treating organic pollutants or substances in air or water by using the photodegradation catalyst or the photodegradation catalyst precursor are illustrated.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: June 10, 2014
    Assignee: Microvast, Inc.
    Inventors: Xiao Ping Zhou, Fei Chen, Jeff Qiang Xu
  • Publication number: 20130011738
    Abstract: A cathode material of a lithium ion secondary battery is provided, which includes a cathode active material and a glassy material coating on a surface of the cathode active material. The glassy material is capable of selectively allowing lithium ions to pass therethrough. The lithium ion secondary battery using the cathode material has the long cycle life and the high safety performance.
    Type: Application
    Filed: July 4, 2012
    Publication date: January 10, 2013
    Applicant: Microvast New Materials (Huzhou) Co., LTD.
    Inventor: XIAO-PING ZHOU
  • Publication number: 20100200392
    Abstract: A photodegradation catalyst or a photodegradation catalyst precursor comprises a plurality of domains of an oxide of a first metal distributed in a substrate of a halide or oxyhalide of a second metal, wherein the mole percentage of the halide or oxyhalide of the second metal is above 50%. Additionally, a method of preparing a photodegradation catalyst or a photodegradation catalyst precursor, a photodegradation catalyst or a photodegradation catalyst precursor obtained from the method and a method of treating organic pollutants or substances in air or water by using the photodegradation catalyst or the photodegradation catalyst precursor are illustrated.
    Type: Application
    Filed: June 1, 2007
    Publication date: August 12, 2010
    Applicant: Microvast, Inc.
    Inventors: Xiao Ping Zhou, Fei Chen, Jeff Qiang Xu
  • Publication number: 20090269258
    Abstract: A catalytic reaction device for fluid-solid heterogeneous catalytic reactions including a distributor, flow controllers, parallel reactors, temperature controllers, coolers and product receivers with reactive fluids flowing into the flow controllers to control the total flow of a fluid is provided.
    Type: Application
    Filed: December 13, 2006
    Publication date: October 29, 2009
    Applicant: MICROVAST TECHNOLOGIES, LTD.
    Inventors: Jangping Yi, Li Huang, Wensheng Li, Xiao Ping Zhou
  • Publication number: 20090262332
    Abstract: Disclosed are high-throughput spectral imaging and spectroscopy apparatus and methods that acquire the property information of measured substance's UV-visible and infrared radiation through using at least one substantially uniform monochromatic incident irradiation source and spatial resolved array detector. The high-throughput analysis is achieved by acquiring a parallel spectral imaging and spectroscopy over a library element substrate. The apparatus and methods include both hardware and software for achieving both spectral imaging and spectroscopic analysis.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 22, 2009
    Applicant: MICROVAST, INC.
    Inventors: Jeff Qiang Xu, Jiang Ping Yi, Xiao Ping Zhou
  • Patent number: 7241424
    Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: July 10, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Shenheng Guan, Lynn Van Erden, Robert C. Haushalter, Xiao Ping Zhou, Xuejun Jason Wang, Ravi Srinivasan
  • Patent number: 7148390
    Abstract: Alcohols, ethers, aldehydes, and olefins are manufactured from alkanes by mixing an alkane and a halogen selected from the group including chlorine, bromine, and iodine in a reactor to form alkyl halide and hydrogen halide. The alkyl halide only or the alkyl halide and the hydrogen halide are directed into contact with metal oxide to form an alcohol and/or an ether, or an olefin and metal halide. The metal halide is oxidized to form original metal oxide and halogen, both of which are recycled.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: December 12, 2006
    Assignees: GRT, Inc., The Regents of the University of California
    Inventors: Xiao Ping Zhou, Ivan Marc Lorkovic, Jeffrey H. Sherman
  • Patent number: 7115231
    Abstract: An apparatus for use in parallel reaction of materials. The apparatus includes a base having a plurality of reaction wells formed therein and a sealing device positioned over the reaction wells for individually sealing each of the reaction wells. One of the sealing device and the base having chamfered ridges extending generally around a periphery of each of said plurality of reaction wells. The other of the sealing device and the base having a contact surface formed of a material softer than the material of the chamfered ridges to create a knife-edge seal between the sealing device and the base when the sealing device and the base are forced into contact with one another.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: October 3, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Xiao Ping Zhou, Sam Bergh, Christopher E. Dube, Lynn Van Erden
  • Patent number: 6933409
    Abstract: Noble metal/reducible metal oxide catalysts effective for the direct amination of aromatic hydrocarbons and heterocyclic analogs thereof are disclosed. In one embodiment, the cataloxidant comprises a noble metal selected from Pd, Rh, Ir and/or Ru and a reducible metal oxide. In another embodiment, the cataloxidant comprises a noble metal and a reducible oxide of a metal selected from Ni, Mn, V, Ce, Th, Pr, Te, Re, Co, Fe, Cu and/or Bi. A preferred cataloxidant comprises one or more noble metals selected from Pd, Rh, Ir and/or Ru, in combination with nickel oxide and/or manganese oxide. In preferred applications, benzene can be aminated in the presence of the cataloxidants to form aniline. A benzene conversion of at least 5% is achieved, with more than 90% selectivity for aniline. Significantly, the cataloxidant can be regenerated without a substantial loss of performance.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: August 23, 2005
    Assignees: Symyx Technologies, Inc., Bayer AG
    Inventors: Damodara M. Poojary, Ramesh Borade, Alfred Hagemeyer, Xiao Ping Zhou, Christopher E. Dube, Ulrich Notheis, Ralph Armbrust, Christian Rasp, David M. Lowe
  • Patent number: 6869799
    Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: March 22, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Shenheng Guan, Lynn Van Erden, Robert C. Haushalter, Xiao Ping Zhou, Xuejun Jason Wang, Ravi Srinivasan
  • Patent number: 6667009
    Abstract: Methods and devices for rapidly analyzing groups of reactions are disclosed. The method includes the steps of contacting a fluid sample from one of the reaction mixtures with a sorbent, trapping at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample trapped on the sorbent. The contacting step, the trapping step, and the detecting step are carried out at least once for each of the reaction mixtures in rapid serial or parallel fashion. The present invention is useful for screening combinatorial libraries, especially libraries of catalysts made through parallel synthesis, but the disclosed methods and devices can be used to analyze a broad spectrum of chemical transformations.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: December 23, 2003
    Assignee: Symyx Technologies, Inc.
    Inventors: Peter J. Desrosiers, Christopher E. Dubé, Xiao Ping Zhou
  • Publication number: 20030166973
    Abstract: Alcohols, ethers, aldehydes, and olefins are manufactured from alkanes by mixing an alkane and a halogen selected from the group including chlorine, bromine, and iodine in a reactor to form alkyl halide and hydrogen halide. The alkyl halide only or the alkyl halide and the hydrogen halide are directed into contact with metal oxide to form an alcohol and/or an ether, or an olefin and metal halide. The metal halide is oxidized to form original metal oxide and halogen, both of which are recycled.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 4, 2003
    Applicant: GRT, Inc.
    Inventors: Xiao Ping Zhou, Ivan Marc Lorkovic, Jeffrey H. Sherman
  • Publication number: 20020198416
    Abstract: Alcohols, ethers, and olefins are manufactured from alkanes by mixing an alkane and bromine in a reactor to form alkyl bromide and hydrogen bromide. The alkyl bromide only or the alkyl bromide and the hydrogen bromide are directed into contact with metal oxide to form an alcohol and/or an ether, or an olefin and metal bromide. The metal bromide is oxidized to form original metal oxide and bromine, both of which are recycled.
    Type: Application
    Filed: January 24, 2002
    Publication date: December 26, 2002
    Inventors: Xiao Ping Zhou, Ivan Marc Lorkovic, Jeffrey H. Sherman