Patents by Inventor Xiao-Qin Ren

Xiao-Qin Ren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE VECTORED AUGMENTATION OF PROTEIN DESTRUCTION, EXPRESSION AND/OR REGULATION
    Publication number: 20240124889
    Abstract: The disclosure provides compositions and methods for the Vectored Augmentation of the Destruction, Expression and/or Regulation of proteins, e.g., VA-DER systems and methods.
    Type: Application
    Filed: May 7, 2020
    Publication date: April 18, 2024
    Inventors: Xiao-Qin Ren, Jinzhao Hou, Steven Paul, Kelly Bales
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAUOPATHY
    Publication number: 20240000971
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: November 3, 2021
    Publication date: January 4, 2024
    Inventors: Todd Carter, Wencheng Liu, Jerrah Holth, Jinzhao Hou, Yanqun Shu, Giridhar Murlidharan, Xiao-Qin Ren
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAUOPATHY
    Publication number: 20220339270
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 29, 2020
    Publication date: October 27, 2022
    Applicant: Voyager Therapeutics, Inc.
    Inventors: Wencheng Liu, Todd Carter, Jinzhao Hou, Yanqun Shu, Giridhar Murlidharan, Martin Goulet, Dinah Wen-Yee Sah, Steven Paul, Xiao-Qin Ren, Xin Wang, Hiu Yan Chung
  • MODULATORY POLYNUCLEOTIDES
    Publication number: 20220333131
    Abstract: The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.
    Type: Application
    Filed: December 23, 2021
    Publication date: October 20, 2022
    Inventors: Jinzhao Hou, Xin Wang, Pengcheng Zhou, Xiao-Qin Ren, Dinah Wen-Yee Sah
  • AAV VARIANTS WITH ENHANCED TROPISM
    Publication number: 20220281922
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Inventors: Dinah Wen-Yee SAH, Jinzhao HOU, Kei ADACHI, Wei WANG, Qingmin CHEN, Jenna CARROLL SOPER, Amy REN, Xiao-Qin REN, Benjamin E. DEVERMAN, Viviana GRADINARU, Qin HUANG, Sripriya RAVINDRA KUMAR
  • Lysosomal acid lipase deficiency compositions and methods
    Patent number: 11235036
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: February 1, 2022
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Andrew Hutchinson, John V. W. Reynders, Guillermo del Angel, Nina Jain, Christen D. Forbes, Xiao-Qin Ren, Barbara Burton
  • AAV VARIANTS WITH ENHANCED TROPISM
    Publication number: 20210277418
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 9, 2021
    Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Kei Adachi, Wei Wang, Qingmin Chen, Jenna Carroll Soper, Amy Ren, Xiao-Qin Ren, Benjamin E. Deverman, Viviana Gradinaru, Qin Huang
  • MODULATORY POLYNUCLEOTIDES
    Publication number: 20200270635
    Abstract: The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.
    Type: Application
    Filed: May 4, 2018
    Publication date: August 27, 2020
    Inventors: Jinzhao Hou, Xin Wang, Pengcheng Zhou, Xiao-Qin Ren, Dinah Wen-Yee Sah
  • LYSOSOMAL ACID LIPASE DEFICIENCY COMPOSITIONS AND METHODS
    Publication number: 20190151420
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.
    Type: Application
    Filed: June 16, 2017
    Publication date: May 23, 2019
    Applicant: ALEXION PHARMACEUTICALS, INC.
    Inventors: Andrew Hutchinson, John V.W. Reynders, Guillermo del Angel, Nina Jain, Christen D. Forbes, Xiao-Qin Ren, Barbara Burton