Patents by Inventor Xiao-Shen Ji

Xiao-Shen Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
    Patent number: 8518371
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: August 27, 2013
    Assignee: Natural Pharmacia International, Inc.
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh
  • HYPOXIA-SELECTIVE, WEAKLY BASIC 2-NITROIMIDAZOLE DELIVERY AGENTS AND METHODS OF USE THEREOF
    Publication number: 20110085975
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Application
    Filed: November 29, 2010
    Publication date: April 14, 2011
    Applicant: NATURAL PHARMACIA INTERNATIONAL, INC.
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh
  • Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
    Patent number: 7842278
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: November 30, 2010
    Assignee: Natural Pharmacia International, Inc.
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh
  • Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
    Publication number: 20080102026
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Application
    Filed: October 27, 2006
    Publication date: May 1, 2008
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh