Patents by Inventor Xiao-Song Gong

Xiao-Song Gong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimeric reverse transcriptase
    Patent number: 11834685
    Abstract: Covalently-linked DNA polymerases are provided.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: December 5, 2023
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventor: Xiao-Song Gong
  • NOVEL REVERSE TRANSCRIPTASES AND USES THEREOF
    Publication number: 20230332142
    Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
    Type: Application
    Filed: March 23, 2023
    Publication date: October 19, 2023
    Inventors: Xiao-Song GONG, Yan WANG
  • Reverse transcriptases and uses thereof
    Patent number: 11649453
    Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: May 16, 2023
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Xiao-Song Gong, Yan Wang
  • DIMERIC REVERSE TRANSCRIPTASE
    Publication number: 20210254033
    Abstract: Covalently-linked DNA polymerases are provided.
    Type: Application
    Filed: April 8, 2021
    Publication date: August 19, 2021
    Inventor: XIAO-SONG GONG
  • NOVEL REVERSE TRANSCRIPTASES AND USES THEREOF
    Publication number: 20210207133
    Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
    Type: Application
    Filed: March 24, 2021
    Publication date: July 8, 2021
    Inventors: Xiao-Song GONG, Yan WANG
  • RNA amplification methods
    Patent number: 11021735
    Abstract: Methods of detecting and amplifying short RNAs are provided.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: June 1, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Man Cheng, Xiao-Song Gong, Yan Wang, Adam M. McCoy
  • Dimeric reverse transcriptase
    Patent number: 11021693
    Abstract: Covalently-linked DNA polymerases are provided.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: June 1, 2021
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventor: Xiao-Song Gong
  • Reverse transcriptases and uses thereof
    Patent number: 10988762
    Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: April 27, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Xiao-Song Gong, Yan Wang
  • Methods and compositions for improving efficiency of nucleic acids amplification reactions
    Patent number: 10787694
    Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 29, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Xiao-Song Gong, John Sullivan, Rongdian Fu, Yan Wang, Evan H. Bursey, Man Cheng
  • DIMERIC REVERSE TRANSCRIPTASE
    Publication number: 20200017841
    Abstract: Covalently-linked DNA polymerases are provided.
    Type: Application
    Filed: July 29, 2019
    Publication date: January 16, 2020
    Inventor: XIAO-SONG GONG
  • Dimeric reverse transcriptase
    Patent number: 10364420
    Abstract: Covalently-linked DNA polymerases are provided.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: July 30, 2019
    Assignee: BIO-RAD LABORATORIES, INC
    Inventor: Xiao-Song Gong
  • Reverse transcriptase mixtures with improved storage stability
    Patent number: 10351840
    Abstract: Reverse transcriptase mixtures with improved storage stability are provided.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: July 16, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Jason Ma, Xiao-Song Gong
  • REVERSE TRANSCRIPTASE MIXTURES WITH IMPROVED STORAGE STABILITY
    Publication number: 20190194640
    Abstract: Reverse transcriptase mixtures with improved storage stability are provided.
    Type: Application
    Filed: August 31, 2016
    Publication date: June 27, 2019
    Inventors: Jason Ma, Xiao-Song Gong
  • Compositions and methods for reducing inhibition of RT-PCR
    Patent number: 10301675
    Abstract: In one aspect, compositions and methods for reducing reverse transcriptase (RT) inhibition in RT-PCR are provided. In some embodiments, the RT inhibition reducer is a phosphorothioate oligodeoxycytosine (SdC), phosphorothioate oligodeoxyadenine (SdA), phosphorothioate oligodeoxythymine (SdT), or phosphorothioate oligodeoxyguanosine (SdG).
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: May 28, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Xiao-Song Gong, Yan Wang
  • Buffers for use with polymerases
    Patent number: 10131898
    Abstract: Amplification reaction mixtures comprising a cationic surfactant and an anionic surfactant are provided.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: November 20, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Xiao-Song Gong
  • RNA AMPLIFICATION METHODS
    Publication number: 20180305739
    Abstract: Methods of detecting and amplifying short RNAs are provided.
    Type: Application
    Filed: June 15, 2018
    Publication date: October 25, 2018
    Inventors: Man Cheng, Xiao-Song Gong, Yan Wang, Adam M. McCoy
  • METHODS AND COMPOSITIONS FOR IMPROVING EFFICIENCY OF NUCLEIC ACIDS AMPLIFICATION REACTIONS
    Publication number: 20180258455
    Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 13, 2018
    Inventors: Xiao-Song GONG, John SULLIVAN, Rongdian FU, Yan WANG, Evan H. BURSEY, Man CHENG
  • RNA amplification methods
    Patent number: 10072285
    Abstract: Methods of detecting and amplifying short RNAs are provided.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: September 11, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Man Cheng, Xiao-Song Gong, Yan Wang, Adam M. McCoy
  • NOVEL REVERSE TRANSCRIPTASES AND USES THEREOF
    Publication number: 20180230462
    Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
    Type: Application
    Filed: February 13, 2018
    Publication date: August 16, 2018
    Inventors: Xiao-Song Gong, Yan Wang
  • Methods and compositions for improving efficiency of nucleic acids amplification reactions
    Patent number: 9994887
    Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: June 12, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Xiao-Song Gong, John Sullivan, Rongdian Fu, Yan Wang, Evan H. Bursey, Man Cheng