Abstract: This invention relates to polynucleotides encoding mini-dystrophin proteins, viral vectors comprising the same, and methods of using the same for delivery of mini-dystrophin to a cell or a subject.

Abstract: The invention relates to synthetic polynucleotides encoding fukutin related protein (FKRP). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.

Abstract: Methods, systems and computer program products for radionavigation for swimmers are described. A mobile device configured to estimate a location using radio frequency signals can estimate a position of the swimmer when the mobile device is worn on a limb of the swimmer and periodically submerged. The mobile device can supply auxiliary information to a radionavigation subsystem to correct a navigation solution affected by limb motion of the swimmer and affected by the periodic submersion of the mobile device.

Abstract: Disclosed is use of alphavirus in preparation of antitumor drugs. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to abovementioned alphavirus treatment are further determined, so as to provide a safe and effective solution for antitumor drug administering schemes.

Abstract: Methods and systems for displaying, to a user interface, categories of items for the user to select from for querying the system, in order to enable the system to return to the user images of items of the style desired by the user for possible purchase. The categories of items can be presented to the user interface visually in silhouette form so that the user can select brand and the silhouette image of the style of item desired. Upon selection of the silhouette image, a query is sent to the system and images of the desired style of item are returned to the user interface for presentation to the user, along with certain attributes of the style of the item.

Abstract: Systems, methods and computer-readable storage mediums are disclosed for a pedometer with lag correction. In some implementations, a method comprises: determining, by a first pedometer of an electronic device, a first step count based on sensor data provided by a motion sensor of the electronic device; determining, by a second pedometer of the electronic device, a second step count based on a window of the sensor data; responsive to determining that a step was detected by the second pedometer, determining a third step count based on the window of sensor data; and determining a corrected step count based on the third step count.

Abstract: The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.

Abstract: A method for managing cache data of a mobile terminal includes determining whether first cache data corresponds to an application exists. If it is determined that the first cache data does not exist, a data request is sent to request server data corresponding to the first cache data, the server data is downloaded, forming the first cache data by using the downloaded server data.

Abstract: Systems, methods and computer-readable storage mediums are disclosed for a pedometer with lag correction. In some implementations, a method comprises: determining, by a first pedometer of an electronic device, a first step count based on sensor data provided by a motion sensor of the electronic device; determining, by a second pedometer of the electronic device, a second step count based on a window of the sensor data; responsive to determining that a step was detected by the second pedometer, determining a third step count based on the window of sensor data; and determining a corrected step count based on the third step count.

Abstract: An immunity enhancing therapeutic vaccine includes a gene vector based on recombinant adenovirus and three elements: 1) an HPV antigen including the E6 and E7 multivalent fusion proteins of HPV types 16 and 18, 2) an immunologic adjuvant protein fused with said antigen, which protein may be a heat shock protein (HSP) of Mycobacterium tuberculosis, and 3) an immunostimulant, which may be granulocyte-macrophage colony stimulating factor (GM-CSF). The vaccine is used for the treatment of human papilloma virus infections and related diseases.

Abstract: The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.

Abstract: Embodiments of the disclosure provide a method and apparatus for sharing data. The method includes: initiating the data sharing application on a first terminal; inserting the file to be shared in a webpage of the data sharing application on the first terminal, and generating an URL for the file in the data sharing application; the data-sharing application of the first terminal broadcasts the URL to other terminal, so that other terminals can share the file via the URL. The present disclosure can reduce the cost of data sharing while improve on the real-timeliness.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.

Abstract: Disclosed is a valve disk for a pressure regulating valve having a retaining device to keep a sealing gasket from becoming displaced. The retaining device of the valve disk increases the friction between the sealing gasket and a sealing gasket groove of the valve disk or secures the sealing gasket in place using an annular sleeve around a valve stem, thereby preventing the sealing gasket on the valve disk from tearing out and falling off when the pressure regulating valve is experiencing a high differential pressure or a high current velocity. Accordingly, the retaining device maintains the sealing of the pressure regulating valve, thereby increasing the work life of the pressure regulating valve.

Abstract: Embodiments of the present invention provide a load monitoring apparatus and method. The apparatus includes: an operation unit, configured to determine indication information for indicating a working state of each processing module in the operation unit; a working state unit, configured to receive the indication information from the operation unit, and determine load amount information in a current monitoring period according to the indication information, where the load amount information is used for indicating a load amount state of the operation unit in the current monitoring period; and a load monitoring unit, configured to receive the load amount information from the working state unit and record the load amount information, and send the load amount information to a system controller, so that the system controller adjusts a working frequency of the operation unit according to the load amount information.

Abstract: An electronic device may include a motion sensor for detecting movement of the electronic device. Applications that run on the electronic device such as fitness applications or activity logging applications may use motion sensor data to track a user's physical activity. To avoid mischaracterizing a user's movement, motion sensor circuitry in the electronic device may supplement motion sensor data with additional information in instances where motion sensor data alone may be insufficient to distinguish between different types of physical activity. For example, information on a user's speed may be synthesized with motion sensor data to help characterize a user's movement. Information on a user's speed may be determined based on location information. The location information may, for example, be gathered using IEEE 802.11 transceiver circuitry or, in more rural areas, may be gathered using Global Positioning System receiver circuitry.

Abstract: The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.

Abstract: The present invention relates to a spring adjusting device and a valve assembly. The spring adjusting device comprises an adjusting screw rod, a spring and a spring seat which is located between the adjusting screw rod and the spring; a groove is arranged in the spring seat, which can contain an end part of one end of the adjusting screw rod, and is provided with a cylindrical side wall. The prevent invention can prevent the end part from being separated from the groove, the spring from being bent on the whole, and the overall working performance of the valve assembly can be improved.

Abstract: The present invention relates to a valve stem and valve core assembly and a valve comprising the assembly. The valve core sleeves the valve stem, an adjusting device is arranged on the valve stem, an elastic element is arranged between the adjusting device and the valve core, and a clearance exists among the valve core, the valve stem and the adjusting device, so that the valve core can move relative to the valve stem and the valve can have a good closing performance.