Patents by Inventor Xiaoya Chen

Xiaoya Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230257376
    Abstract: A ROCK inhibitor represented by formula (I), and a preparation method therefor and a use thereof are provided. The ROCK inhibitor has excellent ROCK inhibition activity, particularly shows good selective inhibition on ROCK2 kinase, has good safety and metabolic stability, and is high in bioavailability. The preparation method for the ROCK inhibitor is simple, and the ROCK inhibitor is easy to purify, and therefore has a good application prospect.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 17, 2023
    Inventors: Jinping LI, Jing ZENG, Xiaodan GUO, Wei PENG, Jun LOU, Li LIU, Xiaoya CHEN, Yihan ZHANG, Yongkai CHEN, Chaodong WANG, Wei WU, Yi YUAN
  • Publication number: 20230257382
    Abstract: Disclosed is a heterocyclic compound as represented by formula (I), a tautomer thereof, or a pharmaceutically acceptable salt thereof. The compound has better inhibitory activity on TRPC5, has good metabolic stability in liver micro-particles, and has good clinical pharmacokinetic properties.
    Type: Application
    Filed: June 23, 2021
    Publication date: August 17, 2023
    Inventors: Jinping Li, Xiaodan Guo, Feng Zhou, Jun Lou, Li Liu, Xiaoya Chen, Yihan Zhang, Yongkai Chen, Chaodong Wang
  • Patent number: 10155958
    Abstract: A method for improving plant insect resistance includes providing target genes derived from insects. Constructs based on the nucleotide sequences of these target genes are designed to form interfering molecules. After being eating by insects, the plant can significantly inhibit expression of corresponding genes in insects. This inhibition is not affected by barrier of the insect digestive systems. The method can improve the insect resistance of plants, reduce pesticide applications, lower the costs of agricultural production, and protect the environment.
    Type: Grant
    Filed: March 31, 2012
    Date of Patent: December 18, 2018
    Assignees: Shanghai Institutes for Biological Sciences, CAS, Suzhou Kaiyi Biotechnology Co. Ltd.
    Inventors: Xiaoya Chen, Xiuming Wu, Yingbo Mao, Changqing Yang, Lingjian Wang
  • Publication number: 20150203863
    Abstract: A method includes increasing EXPA1 gene expression or increasing the activity of EXPA1 polypeptide to produce a plant with an improved trait. The method may further include increasing the expression of RDL1 gene or the activity of RDL1 kpolypeptide. expression of GhRDL1 and GhEXPA1 Co-expression of EXPA1 and RDL genes can improve plant traits. These methods have applications in crops and flower productions.
    Type: Application
    Filed: March 31, 2012
    Publication date: July 23, 2015
    Applicant: Shanghai Institutes for Biological Sciences, CAS
    Inventors: Xiaoya Chen, Bing Xu, Zhiping Lin, Lingjian Wang, Xiaoxia Shangguan, Chunmin Shan
  • Patent number: 8895805
    Abstract: A method for improving insect resistance of plants, in which dsRNA of insect's gene is expressed in plants by using transgenic technique, and then the interfering RNAs are formed in the plants. The interfering RNAs then enter into insects' bodies after being ingested by the insect that eats the plant, and conduct RNA interference against the target gene, thereby expression of the target gene is suppressed by RNA interference. A new plant-mediated method for improving insect resistance by suppressing the growth of insects by RNA interference mechanism.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: November 25, 2014
    Assignee: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    Inventors: Xiaoya Chen, Yingbo Mao, Zhiping Lin, Lingjian Wang
  • Publication number: 20140143906
    Abstract: A method for improving plant insect resistance includes providing target genes derived from insects. Constructs based on the nucleotide sequences of these target genes are designed to form interfering molecules. After being eating by insects, the plant can significantly inhibit expression of corresponding genes in insects. This inhibition is not affected by barrier of the insect digestive systems. The method can improve the insect resistance of plants, reduce pesticide applications, lower the costs of agricultural production, and protect the environment.
    Type: Application
    Filed: March 31, 2012
    Publication date: May 22, 2014
    Applicants: SUZHOU KAIYI BIOTECHNOLOGY CO. LTD., SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CAS
    Inventors: Xiaoya Chen, Xiuming Wu, Yingbo Mao, Changqing Yang, Lingjian Wang
  • Publication number: 20100050294
    Abstract: A method for improving insect resistance of plants, in which dsRNA of insect's gene is expressed in plants by using transgenic technique, and then the interfering RNAs are formed in the plants. The interfering RNAs then enter into insects' bodies after being ingested by the insect that eats the plant, and conduct RNA interference against the target gene, thereby expression of the target gene is suppressed by RNA interference. A new plant-mediated method for improving insect resistance by suppressing the growth of insects by RNA interference mechanism.
    Type: Application
    Filed: December 4, 2007
    Publication date: February 25, 2010
    Inventors: Xiaoya Chen, Yingbo Mao, Zhiping Lin, Lingjian Wang
  • Patent number: 5882745
    Abstract: There are disclosed novel composite materials in which polypropylene is reinforced by the inclusion of bamboo fibers. Preferably the polypropylene may be maleated prior to inclusion of the bamboo fibers in order to promote bonding between the bamboo fibers and the polypropylene matrix.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: March 16, 1999
    Assignee: The HongKong Univiersity of Science & Technology
    Inventors: Yongli Mi, Xiaoya Chen, Qipeng Cuo, Chi-Ming Chan