Patents by Inventor Xiao Yan PIMENTEL

Xiao Yan PIMENTEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to further enhance signal amplification for the in situ detection of nucleic acids
    Patent number: 11788124
    Abstract: The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: October 17, 2023
    Assignee: ADVANCED CELL DIAGNOSTICS, INC.
    Inventors: Yuling Luo, Xiao-Jun Ma, Steve Chen, Nan Su, Emerald Doolittle, Bingqing Zhang, Xiaoming Wang, Xingyong Wu, Xiao Yan Pimentel, Helen Jarnagin
  • METHODS TO FURTHER ENHANCE SIGNAL AMPLIFICATION FOR THE IN SITU DETECTION OF NUCLEIC ACIDS
    Publication number: 20210032690
    Abstract: The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.
    Type: Application
    Filed: April 8, 2019
    Publication date: February 4, 2021
    Inventors: Yuling LUO, Xiao-Jun MA, Steve CHEN, Nan SU, Emerald DOOLITTLE, Bingqing ZHANG, Xiaoming WANG, Xingyong WU, Xiao Yan PIMENTEL, Helen JARNAGIN