Patents by Inventor Xiao-Yan Wen

Xiao-Yan Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11998549
    Abstract: The present disclosure relates generally to treatment and diagnosis of diseases, disorders or conditions characterized by vascular leakage. More particularly, the present disclosure relates to methods for treating a vascular leakage-associated disease or disorder in a subject; for reducing vascular leakage in a subject; for reducing reactive oxygen species production in a subject; for inducing apoptosis of neutrophils in a subject; and for increasing survival of a subject having a vascular leakage-associated disease or disorder. The methods comprise administering a G9a and/or G9a-like protein (GLP) methyltransferase inhibitor to the subject. The present disclosure further relates to methods for developing a treatment plan for a subject with a vascular leakage-associated disease, disorder or condition, and for identifying a subject as a candidate for treatment of a vascular leakage-associated disease or disorder.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: June 4, 2024
    Assignee: Unity Health Toronto
    Inventors: Xiao-Yan Wen, Anju Philip, Claudia Dossantos, John Marshall
  • Publication number: 20230174571
    Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salt, solvate and/or derivative thereof. Further, provided are methods of treating a disease, disorder or condition mediated or treatable by activation of SHIP1 comprising administering a compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof. The compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof may be used in the treatment of SHIP1 mediated disease, disorder or conditions including inflammatory bowel disease (IBD), Crohn' disease, ulcerative colitis, multiple myeloma, liver injury, acute hepatitis and severe sepsis.
    Type: Application
    Filed: April 20, 2021
    Publication date: June 8, 2023
    Inventors: Xiao-Yan Wen, Raymond John Andersen, Alice Low-Fung Mui, Yuanyuan Zhao
  • Publication number: 20210361654
    Abstract: The present disclosure relates generally to treatment and diagnosis of diseases, disorders or conditions characterized by vascular leakage. More particularly, the present disclosure relates to methods for treating a vascular leakage-associated disease or disorder in a subject; for reducing vascular leakage in a subject; for reducing reactive oxygen species production in a subject; for inducing apoptosis of neutrophils in a subject; and for increasing survival of a subject having a vascular leakage-associated disease or disorder. The methods comprise administering a G9a and/or G9a-like protein (GLP) methyltransferase inhibitor to the subject. The present disclosure further relates to methods for developing a treatment plan for a subject with a vascular leakage-associated disease, disorder or condition, and for identifying a subject as a candidate for treatment of a vascular leakage-associated disease or disorder.
    Type: Application
    Filed: January 29, 2020
    Publication date: November 25, 2021
    Inventors: Xiao-Yan Wen, Anju Philip, Claudia Dossantos, John Marshall
  • Publication number: 20190255076
    Abstract: The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.
    Type: Application
    Filed: March 11, 2019
    Publication date: August 22, 2019
    Inventors: Xiao-Yan Wen, R. Loch MacDonald, Andrew Baker, Tom A. Schweizer
  • Patent number: 10292991
    Abstract: The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: May 21, 2019
    Assignee: Unity Health Toronto
    Inventors: Xiao-Yan Wen, R. Loch Macdonald, Andrew Baker, Tom A. Schweizer
  • Publication number: 20180064731
    Abstract: The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.
    Type: Application
    Filed: August 2, 2017
    Publication date: March 8, 2018
    Inventors: R. Loch Macdonald, Xiao-Yan Wen, Tom A. Schweizer, Andrew Baker