Abstract: The present disclosure relates generally to treatment and diagnosis of diseases, disorders or conditions characterized by vascular leakage. More particularly, the present disclosure relates to methods for treating a vascular leakage-associated disease or disorder in a subject; for reducing vascular leakage in a subject; for reducing reactive oxygen species production in a subject; for inducing apoptosis of neutrophils in a subject; and for increasing survival of a subject having a vascular leakage-associated disease or disorder. The methods comprise administering a G9a and/or G9a-like protein (GLP) methyltransferase inhibitor to the subject. The present disclosure further relates to methods for developing a treatment plan for a subject with a vascular leakage-associated disease, disorder or condition, and for identifying a subject as a candidate for treatment of a vascular leakage-associated disease or disorder.

Abstract: The present invention relates to systems and methods for implementing wear leveling in a flash memory device that emulates an EEPROM. The embodiments utilize an index array, which stores an index word for each logical address in the emulated EEPROM. Each bit in each index word is associated with a physical address for a physical word in the emulated EEPROM, and the index word keeps track of which physical word is the current word for a particular logical address. The use of the index word enables a wear leveling algorithm that allows for a programming command to a logical address to result in: (i) skipping the programming operation if the data stored in the current word does not contain a “1” that corresponds to a “0” in the data to be stored, (ii) reprogramming one or more bits of the current word in certain situations, or (iii) shifting to and programming the next physical word in certain situations.

Abstract: A computer-implemented method is provided that includes receiving a search request to perform a search in a time series database, where the time series database stores a plurality of sequences of measured values arranged in chronological order, extracting from the search request a condition for performing the search in the time series database, the condition including a target subsequence to be searched for within the plurality of sequences of measured values within the time series database, selecting a search algorithm to perform the search from a plurality of search algorithms registered to the time series database, based on one or more characteristics of the condition and historical statistic data of one or more historical searches conducted on the time series database, and obtaining a search result from the time series database, utilizing the search algorithm.

Abstract: Techniques for signal handling between programs associated with different addressing modes in a computer system are described herein. An aspect includes, based on a signal occurring during execution of a first program in a first runtime environment, wherein the first program and the first runtime environment are associated with a first addressing mode, invoking a first signal exit routine associated with the first addressing mode. Another aspect includes allocating a signal information area (SIA) by the first signal exit routine. Another aspect includes calling a second signal exit routine associated with a second addressing mode that is different from the first addressing mode with an address of the SIA. Another aspect includes allocating a mirror SIA by the second signal exit routine. Another aspect includes handling the signal, and resuming execution based on the handling of the signal.

Abstract: Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.

Abstract: A signal transmission method, a terminal and a network-side device. A first network-side device sends access configuration (AC) indication information to a terminal, the AC indication information being used for indicating to the terminal the currently available AC in an access configuration set (ACS). The terminal receives the access configuration set (ACS) and the access configuration (AC) indication information sent by the network-side device, and determines, according to the AC indication information, the currently available AC in the ACS.

Abstract: A memory device that includes a memory array having pluralities of non-volatile memory cells, a plurality of index memory cells each associated with a different one of the pluralities of the non-volatile memory cells, and a controller. The controller is configured to erase the pluralities of non-volatile memory cells, set each of the index memory cells to a first state, and program first data into the memory array by reading the plurality of index memory cells and determining that a first one of the index memory cells is in the first state, programming the first data into the plurality of the non-volatile memory cells associated with the first one of the index memory cells, and setting the first one of the index memory cells to a second state different from the first state.

Abstract: Devices and methods related to a graphene oxide-based membrane are provided. A method comprises immersing graphene oxide-based layers in a water-based solution, stirring the water-based solution in a swirling motion until the graphene oxide-based layers each physically curve, adding a crosslinker to the water-based solution to cause the formation of saccate graphene oxide-based cells that are connected to each other via channels, and stacking the saccate graphene oxide-based cells on a substrate to form a graphene oxide-based membrane.

Abstract: A method for manufacturing a circuit board with embedded conductive circuits includes providing a first circuit substrate having a first support board and a first peelable film, providing a second circuit substrate having a second support board and a second peelable film, providing an insulating layer to obtain an intermediate body, pressing the intermediate body, and removing the first support board, the first peelable film, the second support board, and the second peelable film. The first circuit substrate includes a first circuit layer. The second circuit substrate includes a second circuit layer. The first circuit layer is electrically coupled to the second circuit layer through the insulating layer.

Abstract: Provided is signaling transmitting and receiving methods, device, network-side device, terminal and storage medium. The signaling transmitting method includes: determining a first parameter set and/or a second parameter set for N resource groups; and transmitting an indication signaling, the indication signaling carries indication information for indicating the first parameter set and/or the second parameter set. The signaling receiving method includes: receiving an indication signaling transmitted by a network-side device. The indication signaling carries indication information for indicating a first parameter set and/or a second parameter set determined by the network-side device for N resource groups. The first parameter set is a Physical Downlink Shared Channel Resource Element (PDSCH RE) mapping set. The second parameter set is a Quasi-Co-Location (QCL) parameter set. N is a positive integer greater than 1.

Abstract: The present disclosure relates to fluid absorbent cores including at least one absorption layer, the layer including at least 80% by weight of water-absorbent polymer particles, 0 to 10% by weight of an adhesive and from 0 to 10% by weight of fibrous material, wherein the water-absorbent polymer particles within the absorption layer are water-absorbent polymer particles having a vortex of 40 s or less and having a roundness of 0.79 to 0.85 and/or a CRC of 38 g/g to 85 g/g.

Abstract: A fabrication method for a semiconductor structure is provided. The method includes: forming a base substrate; forming gate structures on the base substrate where each gate structure includes a first gate portion with first doping ions on the base substrate and a second gate portion on the first gate portion; forming a metal layer on the second gate portions; and forming a metal silicide layer by reacting a portion of the metal layer with each second gate portion through an annealing process. When forming the metal silicide layers, a reaction between the metal layer and the second gate portions has a first reacting rate and a reaction between the metal layer and the first gate portions has a second reacting rate; and the second reacting rate is smaller than the first reacting rate.

Abstract: An example operation may include one or more of generating an initial seed and allocating one or more authorized bits of the initial seed to a plurality of blocks in a distributed ledger, storing the initial seed and an identification of which authorized bits of the initial seed are allocated to each block of the distributed ledger, receiving a final seed value that is partially generated by each of a plurality of nodes configured to access the distributed ledger based on authorized bits of respective blocks updated by each respective node, and generating a random sequence value based on the final seed value and storing the random sequence value in a block of the distributed ledger.

Abstract: The present invention discloses gripper bar locking apparatus and sheet processing device. In particular, the present invention discloses a gripper bar locking apparatus, which is configured to lock and adjust a position of a gripper bar, comprising: a supporting plate having a distal end and a proximal end; a lever portion, a distal end of which is pivotally mounted on the proximal end of the supporting plate; a cartridge movably mounted on a proximal end of the lever portion and provided with a gripper bar abutment; and an adjusting means provided on the cartridge and configured to adjust a position of the cartridge with respect to the lever portion. Further, the present invention relates to the sheet processing device including the gripper bar. By using the gripper bar locking apparatus, the adjustment of the position of the gripper bar is facilitated.

Abstract: Provided is signaling transmitting and receiving methods, device, network-side device, terminal and storage medium. The signaling transmitting method includes: determining a first parameter set and/or a second parameter set for N resource groups; and transmitting an indication signaling, the indication signaling carries indication information for indicating the first parameter set and/or the second parameter set. The signaling receiving method includes: receiving an indication signaling transmitted by a network-side device. The indication signaling carries indication information for indicating a first parameter set and/or a second parameter set determined by the network-side device for N resource groups. The first parameter set is a Physical Downlink Shared Channel Resource Element (PDSCH RE) mapping set. The second parameter set is a Quasi-Co-Location (QCL) parameter set. N is a positive integer greater than 1.

Abstract: The present disclosure provides, in part, a priming and boosting vector-based platform to develop vaccines against pathogensthat is tailored to elicit a broad T cell response targeting conserved viral epitopes. The universal vaccines are prepared against an immunogen of an infectious pathogenic organism selected from a virus, a bacteria, a fungus or a protozoan comprising at least one ribonucleic acid (RNA) polynucleotide comprising an open reading frame encoding at least one polypeptide antigen or an immunogenic fragment thereof, wherein the polypeptide antigen, or the immunogenic fragment thereof, comprises a conserved internal protein that is enriched in CD8+ T cell recognition antigens. The effectiveness of the priming and boosting platform is tested in a humanized mouse model comprising a fully functional human immune system.

Abstract: A method, computer system, and computer readable product for trajectory data compression are disclosed. In embodiments, the method comprises generating spatial data for one or more moving objects; projecting the data onto a network comprised of a plurality of trajectories, the network constraining movement of the one or more moving objects; and storing the projected data in a data store. In embodiments of the invention, the method further comprises translating updates and queries to the spatial data, using specified data of the network, into links to the data store, and using the links to update and query the data store. In embodiments of the invention, the specified data of the network are stored in a network store. In embodiments of the invention, each of the trajectories includes one or more sub-trajectories, and the projecting the spatial data onto a network includes projecting the spatial data onto the sub-trajectories.

Abstract: A memory device that includes a memory array having pluralities of non-volatile memory cells, a plurality of index memory cells each associated with a different one of the pluralities of the non-volatile memory cells, and a controller. The controller is configured to erase the pluralities of non-volatile memory cells, set each of the index memory cells to a first state, and program first data into the memory array by reading the plurality of index memory cells and determining that a first one of the index memory cells is in the first state, programming the first data into the plurality of the non-volatile memory cells associated with the first one of the index memory cells, and setting the first one of the index memory cells to a second state different from the first state.

Abstract: Disclosed is a membrane surface modification method. The method is applicable to a variety of hydrophobic membranes by doping selected inorganic particles. One act of the method involves the in-situ embedment of the inorganic particles onto the membrane surface by dispersing the particles in a non-solvent bath for polymer precipitation. Further membrane surface modification can be achieved by hydrothermally growing new inorganic phase on the embedded particles. The embedment of particles is for the subsequent phase growth.

Abstract: An example operation may include one or more of generating an initial seed and allocating one or more authorized bits of the initial seed to a plurality of blocks in a distributed ledger, storing the initial seed and an identification of which authorized bits of the initial seed are allocated to each block of the distributed ledger, receiving a final seed value that is partially generated by each of a plurality of nodes configured to access the distributed ledger based on authorized bits of respective blocks updated by each respective node, and generating a random sequence value based on the final seed value and storing the random sequence value in a block of the distributed ledger.