Patents by Inventor Xiao-Yong Li

Xiao-Yong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening methods based on isolating a collection of polynucleotides corresponding to accessible regions of chromatin
    Patent number: 7097978
    Abstract: Methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin, are provided.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: August 29, 2006
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone
  • Compositions and methods for protein production
    Publication number: 20060063231
    Abstract: Disclosed herein are methods and compositions for enhanced protein production and overexpression using engineered zinc finger proteins.
    Type: Application
    Filed: September 8, 2005
    Publication date: March 23, 2006
    Inventors: Xiao-Yong Li, Andrew Jamieson, Victor Bartsevich, Trevor Collingwood
  • Pharmacogenomics and idenitfication of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
    Publication number: 20030190664
    Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.
    Type: Application
    Filed: May 8, 2003
    Publication date: October 9, 2003
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone
  • Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
    Patent number: 6610489
    Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: August 26, 2003
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone
  • Databases of regulatory sequences; methods of making and using same
    Publication number: 20030129603
    Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.
    Type: Application
    Filed: October 24, 2001
    Publication date: July 10, 2003
    Inventors: Alan P. Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone, Elizabeth J. Wolffe
  • Methods for designing exogenous regulatory molecules
    Patent number: 6511808
    Abstract: Methods for the design of exogenous regulatory molecules, comprising a DNA-binding domain and a functional domain, are provided. The methods rely on the identification, isolation and characterization of regulatory DNA sequences obtained on the basis of their accessibility in cellular chromatin.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: January 28, 2003
    Assignee: Sangamo Biosciences, Inc.
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone
  • Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
    Publication number: 20020127559
    Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.
    Type: Application
    Filed: April 27, 2001
    Publication date: September 12, 2002
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone
  • Databases of regulatory sequences; methods of making and using same
    Publication number: 20020081603
    Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.
    Type: Application
    Filed: April 27, 2001
    Publication date: June 27, 2002
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone
  • Methods for designing exogenous regulatory molecules
    Publication number: 20020076711
    Abstract: Methods for the design of exogenous regulatory molecules, comprising a DNA-binding domain and a functional domain, are provided. The methods rely on the identification, isolation and characterization of regulatory DNA sequences obtained on the basis of their accessibility in cellular chromatin.
    Type: Application
    Filed: April 27, 2001
    Publication date: June 20, 2002
    Inventors: Alan Wolffe, Fyodor Urnov, Dmitry Guschin, Trevor Collingwood, Xiao-Yong Li, Brian Johnstone