Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract: A particle detection system is provided. The particle detection system comprises at least one transmitter; at least one receiver; a first interrogation volume formed by a first intersection of a first pair of a transmitter beam of a transmitter and a receiver field of view of a receiver; and a second interrogation volume formed by a second intersection of a second pair of a transmitter beam of a transmitter and a receiver field of view of a receiver.

Abstract: A system for obtaining air data for a vehicle comprises a laser device that emits laser light pulses, and transmit optics that transmits the light pulses into an external air volume adjacent to the vehicle. The system also includes receive optics that collects scattered portions of the light pulses from the external air volume, and a whispering gallery mode (WGM) frequency discriminator that receives the scattered portions of the light pulses from the receive optics. The WGM frequency discriminator includes at least one WGM resonator that outputs a selected portion of the light pulses at one or more optical signal frequencies via tuning the WGM resonator other than by an electro-optic effect. An optical detector samples the selected portion of the light pulses from the WGM frequency discriminator, and converts the sampled light pulses to scalar values. A processing unit receives and records the scalar values from the optical detector.

Abstract: In one embodiment, a particle sensor on or in a vehicle is provided. The laser particle sensor comprises an optical system; a processing system coupled to the optical system; wherein the optical system is configured to transmit one or more laser light beams to detect particles in a volume of freestream fluid, and to have the one or more light beams terminate on a portion of the vehicle on which the optical system is mounted; and wherein the optical system is configured to receive a backscattered portion of the one or more laser light beams transmitted by the optical system.

Abstract: In one embodiment, a method of determining the onset of a stall condition in a vehicle is provided. The method comprises: measuring, with a stall detection system, data which would indicate the presence of turbulent fluid flowing proximate to a foil; determining from the data whether an onset of a stall condition has occurred; and upon determining the onset of the stall condition, performing at least one of: issuing an alert, and causing the vehicle to avoid or exit the stall condition, and cease such activity when the onset of the stall condition no longer exists.

Abstract: A system includes a light detection and ranging (LiDAR) unit comprising an atmospheric characterization transceiver module. The LiDAR unit is configured to transmit light into an external interaction air region, and collect scattered portions of the transmitted light from the external interaction air region. A robotic arm is operatively coupled to the atmospheric characterization transceiver module. A processor is in operative communication with the robotic arm. The processor is configured to control the robotic arm to position and point the atmospheric characterization transceiver module in a direction of interest to interrogate the external interaction air region.

Abstract: A system comprises a particle sensor assembly, which includes a light source that transmits a light beam into an external interrogation air region; a set of receive optics that provides a receive channel, the receive optics configured to collect a scattered portion of the light beam from a particle in the interrogation air region; and an optical detector that receives the collected scattered portion. The optical detector measures a signal intensity as a function of time from the scattered portion, with the signal intensity indicating a particle size and a signal duration indicating motion of the particle through the interrogation air region. A processor is in communication with the optical detector and is operative to determine a transit time of the particle through the interrogation air region based on the signal duration, and compute an airspeed based on parameters comprising the transit time and a size of the light beam.

Abstract: A method of enhancing LiDAR data is provided. The method includes inputting LiDAR data from at least one LiDAR sensor; inputting data from at least one of: at least one static pressure sensor; and at least one total air temperature sensor; and extracting accurate air data parameters by processing one of: the LiDAR data and static pressure data from the static pressure sensor; the LiDAR data and true temperature data from the total air temperature sensor; or the LiDAR data, the static pressure data from the static pressure sensor, and the true temperature data from the total air temperature sensor. The method also includes generating augmented air data based on the extracted accurate air data parameters and outputting the augmented air data.

Abstract: A system for multispectral imaging and ranging is provided. The system comprises at least one light illumination source, and a focal plane detector array configured to support both passive imaging and active imaging at multiple wavelengths. The focal plane detector array includes a plurality of pixels, wherein each of the pixels comprises a plurality of detectors. The detectors are configured to collect passive light to support passive imaging; collect retro-reflected light, transmitted by the at least one light illumination source, to support active illuminated imaging; and collect retro-reflected light, transmitted by the at least one light illumination source, to support active illuminated ranging.

Abstract: A method of fabricating three-dimensional (3D) structures comprises forming a patterned area in a handle wafer, and bonding a mold wafer over the patterned area to produce one or more sealed cavities having a first pressure in the handle wafer. The mold wafer is heated past its softening point at a second pressure different from the first pressure to create a differential pressure across the mold wafer over the sealed cavities. The mold wafer is then cooled to harden the mold wafer into one or more 3D shapes over the sealed cavities. One or more materials are deposited on an outer surface of the mold wafer over the 3D shapes to form a structure layer having 3D structures that conform to the hardened 3D shapes of the mold wafer. The 3D structures are then bonded to a device wafer, and the handle wafer is removed to expose the 3D structures.

Abstract: Disclosed are compounds of Formula (I) or salts thereof, wherein HET is a heteroaryl selected from pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3 d]pyrimidinyl, pyrazolo[3,4 b]pyridinyl, pyrazolo[3,4 d]pyrimidinyl, imidazolo[4,5 b]pyridinyl, and imidazolo[4,5 d]pyrimidinyl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a nitrogen ring atom in said heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb; A is pyrazolyl, imidazolyl, triazolyl, isoxazolyl, oxadiazolyl or dihydroisoxazolyl, each substituted with zero or 1 Ra; and R3, Ra, and Rb are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

Abstract: A particle detection system is provided. The particle detection system comprises at least one transmitter; at least one receiver; a first interrogation volume formed by a first intersection of a first pair of a transmitter beam of a transmitter and a receiver field of view of a receiver; and a second interrogation volume formed by a second intersection of a second pair of a transmitter beam of a transmitter and a receiver field of view of a receiver.

Abstract: A sensor assembly comprises a device mounted on a surface of a vehicle and extending through at least one passage in the surface of the vehicle, and a sensor comprising a short range particulate (SRP) sensor, or a light detection and ranging (LiDAR) air data sensor. The sensor is co-located and integrated with the device mounted on the surface of the vehicle. No additional passages through the surface of the vehicle are needed to integrate the sensor with the device.

Abstract: A system for obtaining air data for a vehicle comprises a laser device that emits laser light pulses, and transmit optics that transmits the light pulses into an external air volume adjacent to the vehicle. The system also includes receive optics that collects scattered portions of the light pulses from the external air volume, and a whispering gallery mode (WGM) frequency discriminator that receives the scattered portions of the light pulses from the receive optics. The WGM frequency discriminator includes at least one WGM resonator that outputs a selected portion of the light pulses at one or more optical signal frequencies via tuning the WGM resonator other than by an electro-optic effect. An optical detector samples the selected portion of the light pulses from the WGM frequency discriminator, and converts the sampled light pulses to scalar values. A processing unit receives and records the scalar values from the optical detector.

Abstract: Disclosed are compounds of Formula (I) or salts thereof, wherein HET is a heteroaryl selected from pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3 d]pyrimidinyl, pyrazolo[3,4 b]pyridinyl, pyrazolo[3,4 d]pyrimidinyl, imidazolo[4,5 b]pyridinyl, and imidazolo[4,5 d]pyrimidinyl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a nitrogen ring atom in said heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb; A is pyrazolyl, imidazolyl, triazolyl, isoxazolyl, oxadiazolyl or dihydroisoxazolyl, each substituted with zero or 1 Ra; and R3, Ra, and Rb are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

Abstract: In one embodiment, a method of determining the onset of a stall condition in a vehicle is provided. The method comprises: measuring, with a stall detection system, data which would indicate the presence of turbulent fluid flowing proximate to a foil; determining from the data whether an onset of a stall condition has occurred; and upon determining the onset of the stall condition, performing at least one of: issuing an alert, and causing the vehicle to avoid or exit the stall condition, and cease such activity when the onset of the stall condition no longer exists.

Abstract: Systems and methods for using dissimilar LIDAR technologies are provided. In at least one implementation A system for gathering LIDAR data comprises one or more LIDAR optical modules configured to provide data from optical measurements of an environment; one or more processing units configured to process the data provided by the one or more LIDAR optical modules; and wherein the one or more processing units produces a plurality of similar LIDAR measurements, wherein the plurality of similar LIDAR measurements were produced using at least one of dissimilar processing and LIDAR optical modules.

Abstract: A system for multispectral imaging and ranging is provided. The system comprises at least one light illumination source, and a focal plane detector array configured to support both passive imaging and active imaging at multiple wavelengths. The focal plane detector array includes a plurality of pixels, wherein each of the pixels comprises a plurality of detectors. The detectors are configured to collect passive light to support passive imaging; collect retro-reflected light, transmitted by the at least one light illumination source, to support active illuminated imaging; and collect retro-reflected light, transmitted by the at least one light illumination source, to support active illuminated ranging.

Abstract: In one embodiment, a particle sensor on or in a vehicle is provided. The laser particle sensor comprises an optical system; a processing system coupled to the optical system; wherein the optical system is configured to transmit one or more laser light beams to detect particles in a volume of freestream fluid, and to have the one or more light beams terminate on a portion of the vehicle on which the optical system is mounted; and wherein the optical system is configured to receive a backscattered portion of the one or more laser light beams transmitted by the optical system.

Abstract: In one embodiment, a system includes a vehicle and a laser air data sensor, including a laser transceiver configured to transmit one or more laser light beams, mounted to the vehicle. In some embodiments, a window of the laser transceiver is fixed and oriented to transmit one or more laser light beams away from the vehicle and approximately parallel to a vertical axis of the vehicle. In some embodiments, a window of the laser transceiver is fixed and oriented to transmit one or more laser light beams toward another portion of the vehicle. In some embodiments, the system further includes a processing device configured to control the laser air data sensor to attenuate the one or more laser light beams based on one or more operating parameters of the vehicle.