Abstract: The present invention relates to the field of pharmaceutical and chemical engineering, and specifically relates to a weakly acidic microenvironment-sensitive aptamer for tumors, a triptolide conjugate. The conjugate is formed by conjugation between the 14-position hydroxyl group of triptolide and the aptamer via an acetal ester linking bond, which is an acid-sensitive linking bond with a cleavage condition of (pH=3.5-6.5), which is much less pH-sensitive and is more likely to cleave under the tumor microenvironment. Based on the characteristics of the aptamer targeting the highly expressed proteins on the membrane surface of tumor cells, the conjugate delivered triptolide targeted to tumor cells and mediated endocytosis to reach the lysosome; based on the characteristics of the acidic environment of lysosomes, the acetal ester linking bond released intact triptolide in the lysosomal acidic environment, targeting and killing of tumor cells.

Abstract: A reasonable millisecond time control method for excavation blasting of a tunnel is provided, and includes: acquiring physical mechanical parameters to establish a millisecond blasting model, and designing four dimensions blasting parameters of explosive quantity, hole number, inter-hole millisecond and inter-row millisecond; simulating, based on the millisecond blasting model, a blasting process of an explosive package using blasting parameters to obtain a blasting vibration curve; obtaining single-hole blasting vibration waveforms, solving a vibration synthesis curve through a vibration synthesis theory; comparing the vibration synthesis curve with the blasting vibration curve to obtain a coupling relationship of blasting parameters; determining a target group of explosive quantity and hole numbers, determining a target millisecond through the coupling relationship of blasting parameters, and relating a millisecond blasting control strategy to control, and it is used for tunneling project to reduce cut blas

Abstract: The present disclosure relates to an in vivo duct repair device and an operating method thereof. The in vivo duct repair device includes a catheter; a nozzle assembly, two axial ends thereof including a supplying end and a spraying end, respectively, the nozzle assembly having a first material flow channel arranged inside the nozzle assembly, a first material spout communicated with the first material flow channel and spraying a first material radially outwards, a second material flow channel arranged inside the nozzle assembly and isolated from the first material flow channel and a second material spout communicated with the second material flow channel and spraying a second material radially outwards, and the nozzle assembly being configured to enter the catheter and extend the spraying end out of an introducing end of the catheter; and a drive device connected to the supplying end.

Abstract: The present disclosure provides a bioprinter nozzle, a bioprinter and a lumen tissue construct printing method. The bioprinter nozzle includes: a bio-ink flow channel disposed inside the bioprinter nozzle; a bio-ink ejection port in communication with the bio-ink flow channel and located on the lateral side of an ejection end of the bioprinter nozzle; a medical adhesive flow channel disposed inside the bioprinter nozzle and isolated from the bio-ink flow channel; and a medical adhesive ejection port in communication with the medical adhesive flow channel and disposed on the lateral side of the ejection end, the medical adhesive ejection port and the bio-ink ejection port being arranged in a staggered manner in the axial direction of the bioprinter nozzle. The bioprinter includes the bioprinter nozzle. The lumen tissue construct printing method uses the bioprinter for printing.

Abstract: The invention relates to the technical filed of tissue engineering and 3D printing, particularly relates to an artificial tissue progenitor and a method for preparing the same.

Abstract: A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.

Abstract: A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.

Abstract: The present disclosure relates to a manufacturing method of a lumen tissue construct. The manufacturing method of a lumen tissue construct comprises: step 1: installing elastic film on a support in a sleeving manner; step 3: printing a biological construct on the elastic film; step 5: forming a construct bonding layer on the biological construct; and step 7: bonding a lumen tissue to the construct bonding layer. In the manufacturing method of the lumen tissue construct of the present disclosure, the printed biological construct is assembled on the inner surface of the lumen tissue to form the lumen tissue construct, thereby helping to avoid occurrence of problems such as recurrence of thrombus, restenosis of lumen and the like after the lumen tissue construct is implanted for a long time, and improving the biological reliability of the lumen tissue construct.

Abstract: The invention relates to the technical filed of tissue engineering and 3D printing, particularly relates to an artificial tissue progenitor and a method for preparing the same.

Abstract: A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.

Abstract: The invention relates to the technical filed of tissue engineering and 3D printing, particularly relates to an artificial tissue progenitor and a method for preparing the same.

Abstract: The present invention relates to communication technology. Disclosed are a method and device for activating and deactivating a secondary component carrier (SCC) in carrier aggregation. When the cache data volume reported by an RLC reaches an activation data volume threshold, increasing the count value of an SCC activation counter instead of directly activating an SCC; when determining that a monitor condition is met, and if the ratio of the count value of the SCC activation counter and the report times of the RLC reaches a set activation threshold, then indicating that the cache data volumes reported for multiple times all reach the activation data volume threshold, and then activating the SCC, thus avoiding multiple activations and deactivations during a short time, and improving SCC rate stability.

Abstract: A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.

Abstract: The present invention relates to communication technology. Disclosed are a method and device for activating and deactivating a secondary component carrier (SCC) in carrier aggregation. When the cache data volume reported by an RLC reaches an activation data volume threshold, increasing the count value of an SCC activation counter instead of directly activating an SCC; when determining that a monitor condition is met, and if the ratio of the count value of the SCC activation counter and the report times of the RLC reaches a set activation threshold, then indicating that the cache data volumes reported for multiple times all reach the activation data volume threshold, and then activating the SCC, thus avoiding multiple activations and deactivations during a short time, and improving SCC rate stability.