Abstract: A light-emitting diode display panel, a manufacturing method thereof, and an organic light-emitting diode display device are provided. The light-emitting diode display panel includes: a base substrate including a display region and a peripheral region surrounding the display region; a plurality of sub-pixels located in the display region and located at a side of the base substrate; a color-resistance layer located at a side of a second electrode in the sub-pixel away from the base substrate; and a light-blocking structure located in the peripheral region and being an annular structure surrounding the plurality of sub-pixels. The light-blocking structure includes a first light-blocking structure and a second light-blocking structure. The first light-blocking structure includes at least one interval extending in a direction from the display region pointing to the peripheral region. The second light-blocking structure at least fully fills the interval.

Abstract: The present disclosure relates to compositions and methods for reducing side effects and/or enhancing cancer treatment that use modified immune cells expressing chimeric antigen receptors (CARs) or modified T cell receptors (TCRs). The modified immune cells, such as T cells or NK cells, can express CARs or TCRs targeting solid tumor antigens, white blood cell antigens like CD19, or bispecific CARs/TCRs targeting both. The methods include administering dasatinib to reduce the side effects associated with CAR T or TCR therapy and/or enhance cancer treatment. The modified cells can co-express additional therapeutic agents like cytokines.

Abstract: A quick insertion locking connector is disclosed and includes a female connector body, a receiving joint providing with multiple limiting holes, a sliding sleeve sleeving a first boss provided on an outer wall of the receiving joint, a protective sleeve and a sealing ring. Limiting elements are arranged in the limiting holes. A second boss abuts against the outer wall of the receiving joint. A recess and a boss base extending along inside of the receiving joint are formed on an inner wall of the receiving joint. The sealing ring is arranged on the boss base and extends into the recess. Multiple limiting grooves are circumferentially formed in an outer wall of a male connector body which is configured for being inserted into the receiving joint and abutting against the sealing ring located on the boss base and the sealing ring located in the recess.

Abstract: The present invention discloses a quick-insertion coupling joint, where a socket is arranged in one end of a female coupler body, a seal retainer is arranged in an inner wall of the socket, a sealing gasket is arranged at the seal retainer, multiple limiting holes are arranged in a side wall of the socket, a limiting element is arranged in each limiting hole, a first boss is arranged on an outer side wall of the female coupler body, the sliding sleeve sleeves the exterior of the first boss, a coupling groove is arranged in the outer side wall of the female coupler body, a retaining ring is arranged in the coupling groove, a second boss is arranged on an inner wall of the sliding sleeve, elastic elements sleeve the exterior of the female coupler body and are arranged between the second boss and the first boss

Abstract: A system and method includes a network interface device to receive and retransmit electronic messages between a first user and a second user, an electronic data storage configured to store database entries related to electronic messages as received and retransmitted by the network interface device, at least some of the database entries including a latest message in thread flag identifying a latest electronic message in a thread of multiple electronic messages, and a processor. The processor may create a database entry corresponding to a first electronic message, the database entry including the latest message in thread flag indicating that the first electronic message is a latest electronic message of a thread, and change a status of a latest message in thread flag of a database entry corresponding to a second electronic message of the thread to indicate that the second electronic message is not a latest message in the thread.

Abstract: Embodiments of the invention relate a bearing assembly, which may be operated at least partially hydrodynamically, and includes a support ring having reduced-thickness portions configured to elastically flex for promoting hydrodynamic fluid flow between opposing bearings of the bearing apparatus incorporated in a bearing apparatus. The disclosed bearing assemblies and apparatuses may be employed in downhole motors of a subterranean drilling system or other mechanical systems.

Abstract: A system, apparatus, and methods are provided for conditionally forwarding electronic messages. Users of an online application or service are provided internal addresses (e.g., electronic mail addresses) within a domain (e.g., an Internet domain) of the application or service. When a message is received that is addressed to a user's internal address, it is queued for conditional forwarding to an external address of the user (e.g., an electronic mail address in a domain other than the domain of the application or service). After a threshold period of time lapses, if the message was not read via the online system (e.g., via web or mobile client software) it is forwarded to the external address. If additional messages were received for the same conversation or thread, they may be forwarded at the same time. Messages may be forwarded in their original form; multiple messages may be forwarded in digest form.

Abstract: A system and method of fabricating a percussion tool that includes one or more coatings applied onto a piston, casing, and/or flow tube. The percussion tool includes a piston positioned in sliding contact within a casing. The piston includes an inner wall and an outer wall, where the inner wall defines a passageway extending longitudinally therethrough. The outer wall is positioned in close fitting relationship with an internal surface of the casing. One or more coatings are disposed on at least one of the casing's internal surface and/or the piston's outer wall. A flow tube may be placed through the passageway such that an outer wall of the flow tube is in a close fitting relationship with the piston's inner wall. One or more coatings can be disposed on at least one of the piston's inner wall and/or the flow tube's outer wall.

Abstract: Bearing assemblies, apparatuses, and motor assemblies using the same are disclosed. In an embodiment, a bearing assembly may include a plurality of superhard bearing elements distributed circumferentially about an axis. Each of the superhard bearing elements may include a bearing surface and a side. At least one of the plurality of superhard bearing elements may include a hollow at least partially defined by a side of the superhard bearing element that is configured to force fluid toward the bearing surface during operation. The bearing assembly may also include a support ring that carries the superhard bearing elements.

Abstract: Embodiments of the invention relate a bearing assembly, which may be operated at least partially hydrodynamically, and includes a support ring having reduced-thickness portions configured to elastically flex for promoting hydrodynamic fluid flow between opposing bearings of the bearing apparatus incorporated in a bearing apparatus. The disclosed bearing assemblies and apparatuses may be employed in downhole motors of a subterranean drilling system or other mechanical systems.

Abstract: A system and method includes a network interface device to receive and retransmit electronic messages between a first user and a second user, an electronic data storage configured to store database entries related to electronic messages as received and retransmitted by the network interface device, at least some of the database entries including a latest message in thread flag identifying a latest electronic message in a thread of multiple electronic messages, and a processor. The processor may create a database entry corresponding to a first electronic message, the database entry including the latest message in thread flag indicating that the first electronic message is a latest electronic message of a thread, and change a status of a latest message in thread flag of a database entry corresponding to a second electronic message of the thread to indicate that the second electronic message is not a latest message in the thread.

Abstract: A system and method of fabricating a percussion tool that includes one or more coatings applied onto a piston, casing, and/or flow tube. The percussion tool includes a piston positioned in sliding contact within a casing. The piston includes an inner wall and an outer wall, where the inner wall defines a passageway extending longitudinally therethrough. The outer wall is positioned in close fitting relationship with an internal surface of the casing. One or more coatings are disposed on at least one of the casing's internal surface and/or the piston's outer wall. A flow tube may be placed through the passageway such that an outer wall of the flow tube is in a close fitting relationship with the piston's inner wall. One or more coatings can be disposed on at least one of the piston's inner wall and/or the flow tube's outer wall.

Abstract: A system and method includes a network interface device to receive and retransmit electronic messages between a first user and a second user, an electronic data storage configured to store database entries related to electronic messages as received and retransmitted by the network interface device, at least some of the database entries including a latest message in thread flag identifying a latest electronic message in a thread of multiple electronic messages, and a processor. The processor may create a database entry corresponding to a first electronic message, the database entry including the latest message in thread flag indicating that the first electronic message is a latest electronic message of a thread, and change a status of a latest message in thread flag of a database entry corresponding to a second electronic message of the thread to indicate that the second electronic message is not a latest message in the thread.

Abstract: The present invention relates to multiple novel approaches for the generation of an immune response in an animal, such as a human, using lentivirus-based vector technology. The invention provides for the ability to mimic the efficacy of a live attenuated (LA) vaccine, without exposing the patient to the risk of disease as possible with some LA vaccines. The invention thus provides for systems of complementary conditionally replicating vectors, vectors that produce replication deficient virus like particles, and multi-antigen constructs that target a virus or microbial pathogen. The use of these materials in the practice of the invention permits the generation of robust cellular and humoral responses to the antigens presented thereby.

Abstract: Network communications, Web-based services and customized services using the Web-based services may be provided to drivers and users via the automobile head unit in the vehicle and via their mobile device. The automobile head unit in the vehicle and the mobile device are communicatively linked via a short range wireless connection. Also, these devices may communicate over a network such as a cellular network to a service provider that provides entertainment and informational services to the mobile device and the head unit of the vehicle. The user's profile and preferences are able to follow the user to various locations and into vehicles because this information is stored at a server accessible by the user's mobile device, and in some embodiments, also the head unit. The mobile device may provide services to the head unit if it does not have wider network connectivity over the short range wireless connection.

Abstract: Network communications, Web-based services and customized services using the Web-based services may be provided to drivers and users via the automobile head unit in the vehicle and via their mobile device. The automobile head unit in the vehicle and the mobile device are communicatively linked via a short range wireless connection. Also, these devices may communicate over a network such as a cellular network to a service provider that provides entertainment and informational services to the mobile device and the head unit of the vehicle. The user's profile and preferences are able to follow the user to various locations and into vehicles because this information is stored at a server accessible by the user's mobile device, and in some embodiments, also the head unit. The mobile device may provide services to the head unit if it does not have wider network connectivity over the short range wireless connection.

Abstract: A drill tool includes a bit body, at least one bearing shaft extending from the bit body and a cone mounted for rotation on the bearing shaft. A mechanical seal is disposed between the bearing shaft and the cone in a seal gland. The mechanical seal includes a rigid seal ring having a dynamic sealing surface with the cone and another non-sealing surface exposed to an aperture in the seal gland. The mechanical seal further includes at least one cooling channel formed in the another non-sealing surface of the rigid seal ring, the cooling channel having an open end in fluid communication with the aperture in the seal gland.

Abstract: A drill tool comprises includes a bit body, at least one bearing shaft extending from the bit body and a cone mounted for rotation on the bearing shaft. The bearing system for the tool includes a radial thrust bearing from which cone pumping pressure pulsation originates. A lubricant sealing system including an annular seal gland and a seal ring retained within the annular seal gland functions to retain lubricant in the bearing system. The tool further includes a lubricant cone pumping pressure restrictor system formed by an annular gland (separate from the annular seal gland) and a pressure restricting ring retained within the annular gland. The lubricant cone pumping pressure restrictor system is positioned between the radial thrust bearing system and the lubricant sealing system and is adapted to attenuate cone pumping lubricant pressure pulsation from acting on the seal ring retained within the annular seal gland.

Abstract: Surface texturing is employed to modify the topography of one or more surfaces (radial or cylindrical) of the sealing system for a roller cone rock bit. The surface texturing produces a regular or repeated patterned dimpled surface which retains additional lubricant helpful in reducing friction in the boundary and mixed lubrication regimes.

Abstract: Network communications, Web-based services and customized services using the Web-based services may be provided to drivers and users via the automobile head unit in the vehicle and via their mobile device. The automobile head unit in the vehicle and the mobile device are communicatively linked via a short range wireless connection. Also, these devices may communicate over a network such as a cellular network to a service provider that provides entertainment and informational services to the mobile device and the head unit of the vehicle. The user's profile and preferences are able to follow the user to various locations and into vehicles because this information is stored at a server accessible by the user's mobile device, and in some embodiments, also the head unit. The mobile device may provide services to the head unit if it does not have wider network connectivity over the short range wireless connection.