Patents by Inventor Xiaobing Chu

Xiaobing Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240274302
    Abstract: Disclosed are a system and method of predicting sensitivity of Klebsiella against MeropeneM, which belong to bioinformatics art. The system comprises a computer readable storage medium on which is stored a computer program. An Exp (?k) power value calculation method is implemented when said computer program is executed by a processor. Said Exp(?k) power value calculation method comprises following computing steps: S1: k value is calculated according to formula I: Formula ? I ? - 1.44 + 0. ? × ( ? ? ) - 0.66 × ( ? ? ) + 0. ? × ( ? ? ) + 3.04 ? × ( ? ? ) - 0.46 × ( ? ? ) ? indicates text missing or illegible when filed S2: Exp(?k) power value with natural constant e as base and ?k as exponent is calculated; wherein, C1-C5 are respectively the number of mphA, marA, Klebsiella pneumoniae KpnE, KPC-1, floR gene copies in the candidate Klebsiella strain.
    Type: Application
    Filed: November 29, 2023
    Publication date: August 15, 2024
    Inventors: Qiwen Yang, Jing CHEN, Wei Yu, Jun Wang, Xiaobing Chu, Shiyu Chen, Qian Zhang, Yao Yao
  • Patent number: 12062414
    Abstract: A system and a method for predicting susceptibility of genus Klebsiella to amikacin are provided. The system includes a calculating unit containing a computer-readable storage medium stored with a computer program; the computer program is used to, when is executed by a processor, implement a calculation method for an Exp(?k) power value, and the calculation method for the Exp(?k) power value includes: step 1, calculating a k value according to formula I; and step 2, calculating the Exp(?k) power value with an Euler's constant e as a base and a ?k value as an exponential; and C1 to C5 are respectively copy numbers of an arr-2 gene, an acrB gene, an armA gene, an oqxB gene, and a rmtB gene in to-be-predicted Klebsiella strains. When the method and the system are adopted to predict the susceptibility of the genus Klebsiella to amikacin, an accuracy rate is about 98.8%.
    Type: Grant
    Filed: November 15, 2023
    Date of Patent: August 13, 2024
    Assignees: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Hangzhou Matridx Biotechnology Co Ltd
    Inventors: Qiwen Yang, Jing Chen, Wei Yu, Jun Wang, Xiaobing Chu, Shiyu Chen, Qian Zhang, YiQun Mi
  • Publication number: 20240265995
    Abstract: Disclosed are a system and method of predicting sensitivity of Klebsiella against Cefoxitin, which belong to bioinformatics art. The system comprises a computer readable storage medium on which is stored a computer program. An Exp (?k) power value calculation method is implemented when the computer program is executed by a processor. The Exp(?k) power value calculation method comprises following computing steps: S1: k value is calculated according to formula I: k = 0.032 - 0.557 × ( C ? 1 - 1.008 0.317 ) + 0.054 × ( C ? 2 - 0.667 1.326 ) + 2.878 × ( C ? 3 - 0.552 1.121 ) + 1.021 × ( C ? 4 - 0.072 0.377 ) + 0.772 × ( C ? 5 - 0.036 0.292 ) Formula ? I S2: Exp(?k) power value with natural constant e as base and ?k as exponent is calculated; wherein, C1-C5 are respectively the number of ramA, sul1, KPC-1, DHA-1, bleomycin resistance determinant gene copies in the candidate Klebsiella strain.
    Type: Application
    Filed: November 29, 2023
    Publication date: August 8, 2024
    Inventors: Qiwen Yang, Jing CHEN, Wei YU, Jun WANG, Xiaobing CHU, Shiyu CHEN, Qian ZHANG, Yao YAO
  • Publication number: 20240265994
    Abstract: A system and a method for predicting susceptibility of genus klebsiella to amikacin are provided. The system includes a calculating unit containing a computer-readable storage medium stored with a computer program; the computer program is used to, when is executed by a processor, implement a calculation method for an Exp(?k) power value, and the calculation method for the Exp(?k) power value includes: step 1, calculating a k value according to formula I; and step 2, calculating the Exp(?k) power value with an Euler's constant e as a base and a ?k value as an exponential; and C1 to C5 are respectively copy numbers of an arr-2 gene, an acrB gene, an armA gene, an oqxB gene, and a rmtB gene in to-be-predicted klebsiella strains. When the method and the system are adopted to predict the susceptibility of the genus klebsiella to amikacin, an accuracy rate is about 98.8%.
    Type: Application
    Filed: November 15, 2023
    Publication date: August 8, 2024
    Inventors: Qiwen Yang, Jing Chen, Wei Yu, Jun Wang, Xiaobing Chu, Shiyu Chen, Qian Zhang, YiQun Mi