Patents by Inventor Xiaobing Li

Xiaobing Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine
    Publication number: 20040167336
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: February 6, 2004
    Publication date: August 26, 2004
    Inventors: Richard Apodaca, Nicholas I. Carruthers, John R. Carson, Wenying Chai, Annette K. Kwok, Xiaobing Li, Timothy W. Lovenberg, Dale A. Rudolph, Chandravadan R. Shah
  • Substituted 4-phenyl-[1,3]-dioxanes
    Publication number: 20040147593
    Abstract: Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 29, 2004
    Inventors: Nicholas I. Carruthers, Todd K. Jones, Xiaobing Li, Timothy W. Lovenberg, Laura C. McAtee, Victor K. Phuong, Dale A. Rudolph, Steven W. Sutton
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Publication number: 20030220493
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I 1
    Type: Application
    Filed: June 2, 2003
    Publication date: November 27, 2003
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6593474
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: July 15, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Linda Mulcahy, Xiaobing Li, Allen Reitz, Cynthia Maryanoff, Frank Villani
  • Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine
    Publication number: 20030013733
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: September 21, 2001
    Publication date: January 16, 2003
    Inventors: Richard Apodaca, Nicholas I. Carruthers, John R. Carson, Wenying Chai, Annette K. Kwok, Xiaobing Li, Timothy W. Lovenberg, Dale A. Rudolph, Chandravadan R. Shah
  • Method for treating histamine H3 receptor-mediated disorders with 2- or 3-aryl substituted imidazo[1,2-a] pyridines
    Patent number: 6489337
    Abstract: The invention features methods of using pharmaceutically-active 2- or 3-aryl substituted imidazopyridines for the treatment of histamine H3 receptor-mediated disorders.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 3, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Timothy W. Lovenberg
  • Novel heterocycles useful in the treatment of benign prostatic hyperplasia
    Publication number: 20020165219
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I 1
    Type: Application
    Filed: November 26, 2001
    Publication date: November 7, 2002
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C.F. Yim, Cynthia Maryanoff
  • Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists
    Patent number: 6436939
    Abstract: The invention features methods of using pharmaceutically-active 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzthiazoles and derivatives.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: August 20, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Nicholas I. Carruthers, Xiaobing Li, Timothy W. Lovenberg
  • Heterocycles useful in the treatment of benign prostatic hyperplasia
    Patent number: 6384035
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: May 7, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
  • Phenyl-substituted imidazopyridines
    Publication number: 20020006934
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Application
    Filed: March 29, 2001
    Publication date: January 17, 2002
    Inventors: J. Guy Breitenbucher, Nicholas I Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Phenyl-substituted indolizines and tetrahydroindolizines
    Publication number: 20010051632
    Abstract: The invention features pharmaceutically-active indolizines and tetrahydroindolizines that are each substituted with phenyl, methods of making them, and methods of using them.
    Type: Application
    Filed: March 29, 2001
    Publication date: December 13, 2001
    Inventors: Wenying Chai, Annette K. Kwok, Xiaobing Li, Dale A. Rudolph
  • Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists
    Publication number: 20010044439
    Abstract: The invention features methods of using pharmaceutically-active 2- or 3-aryl substituted imidazopyridines and derivatives.
    Type: Application
    Filed: March 29, 2001
    Publication date: November 22, 2001
    Inventors: Nicholas I. Carruthers, Xiaobing Li, Timothy W. Lovenberg
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6303594
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: October 16, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allan Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6071915
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: June 6, 2000
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani