Patents by Inventor Xiaobo HAO

Xiaobo HAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12649777
    Abstract: Provided are a bispecific antibody and a monoclonal antibody for a tetanus toxin, and uses of the antibodies. The bispecific antibody contains a first antigen-binding fragment and a second antigen-binding fragment which bind to different epitopes of the tetanus toxin, and has activity of neutralizing the tetanus toxin. The monoclonal antibody binds to the tetanus toxin, and has activity of neutralizing the tetanus toxin.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: June 9, 2026
    Assignees: BEIJING WISDOMAB BIOTECHNOLOGY CO., LTD, GENRIX (SHANGHAI) BIOPHARMACEUTICAL CO. LTD., CHONGQING GENRIX BIOPHARMACEUTICAL CO., LTD.
    Inventors: Zhigang Liu, Xiaowei Zhou, Yulan Liu, Xiaobo Hao, Junjie Hu
  • Patent number: 12559556
    Abstract: A bispecific antibody, which comprises an antigen-binding portion against human CD3E and an antigen-binding portion against human BCMA.
    Type: Grant
    Filed: June 27, 2025
    Date of Patent: February 24, 2026
    Assignee: Chongqing Genrix Biopharmaceutical Co., Ltd.
    Inventors: Zhigang Liu, Shunan Wan, Yulan Liu, Xiaobo Hao, Junjie Hu, Jingjing Guo
  • Patent number: 12509520
    Abstract: A bispecific antibody having an antigen-binding portion for human CD3E and/or an antigen-binding portion for human CD123. Medical and biological uses of the bispecific antibody are also disclosed.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: December 30, 2025
    Assignees: Beijing Wisdomab Biotechnology Co., Ltd, Genrix (Shanghai) Biopharmaceutical Co., Ltd., Chongqing Genrix Biopharmaceutical Co., Ltd.
    Inventors: Zhigang Liu, Xiaobo Hao, Xueping Zhang, Yulan Liu, Jingjing Guo
  • Publication number: 20250388652
    Abstract: Disclosed in the present application are an antibody against respiratory syncytial virus (RSV), a nucleic acid molecule encoding the antibody, an expression vector containing the nucleic acid molecule, a host cell containing the nucleic acid molecule or the vector, and a pharmaceutical composition containing the antibody. Further provided in the present application are a method for preparing and purifying the antibody and the use thereof.
    Type: Application
    Filed: May 3, 2023
    Publication date: December 25, 2025
    Inventors: Xinlei FU, Zhigang LIU, Xiaowei ZHOU, Xiaobo HAO, Yulan LIU, Junjie HU
  • Patent number: 12497455
    Abstract: A bispecific antibody, which comprises an antigen-binding portion against human CD3E and/or an antigen-binding portion against human BCMA. Additionally, provided are medical and biological uses of the bispecific antibody.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: December 16, 2025
    Assignee: CHONGQING GENRIX BIOPHARMACEUTICAL CO., LTD.
    Inventors: Zhigang Liu, Shunan Wan, Yulan Liu, Xiaobo Hao, Junjie Hu, Jingjing Guo
  • Publication number: 20250316266
    Abstract: Disclosed are a method and apparatus for controlling a speech recognition device, an electronic device, and a storage medium. The method includes: recording, when the speech recognition device is in a dormant state, current time as first time in response to detecting that a target object stares at the speech recognition device; recording the current time as second time in response to detecting that the target object makes a speech; and awakening the speech recognition device in response to determining that an interval between the first time and the second time satisfies a preset condition, such that the speech recognition device enters a speech control mode.
    Type: Application
    Filed: December 21, 2022
    Publication date: October 9, 2025
    Inventors: Xiaobo HAO, Shaobin LI, Dechao SONG, Jie TANG, Peng ZHANG
  • Publication number: 20250289901
    Abstract: A bispecific antibody, which comprises an antigen-binding portion against human CD3E and/or an antigen-binding portion against human BCMA. Additionally, provided are medical and biological uses of the bispecific antibody.
    Type: Application
    Filed: June 2, 2025
    Publication date: September 18, 2025
    Inventors: Zhigang Liu, Shunan Wan, Yulan Liu, Xiaobo HAO, Junjie Hu, Jingjing Guo
  • Patent number: 12314832
    Abstract: This application discloses a content recommendation method performed at a computer device and belongs to the field of artificial intelligence. The method includes: acquiring a target user vector of a target user; determining n groups of seed user vectors according to the target user vector, each group of seed user vectors corresponding to a respective piece of candidate recommendation content; invoking a look-alike model to calculate a similarity between the target user vector and each group of seed user vectors, the look-alike model being used for calculating a similarity between user vectors based on an attention mechanism; and determining, among the n pieces of candidate recommendation content, target content to be recommended to the target user according to the respective similarities of the corresponding n groups of seed user vectors. This application can resolve a problem of relatively low accuracy of a recommendation method in the related art.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: May 27, 2025
    Assignee: Tencent Technology (Shenzhen) Company Limited
    Inventors: Yudan Liu, Kaikai Ge, Xu Zhang, Leyu Lin, Xin Chen, Xiaobo Hao, Wei Wang, Kai Zhuang, Su Yan, Zhida Pan, Linyao Tang, Jing Zhang
  • Publication number: 20250129141
    Abstract: Provided are a bispecific antibody and a monoclonal antibody for a tetanus toxin, and uses of the antibodies. The bispecific antibody contains a first antigen-binding fragment and a second antigen-binding fragment which bind to different epitopes of the tetanus toxin, and has activity of neutralizing the tetanus toxin. The monoclonal antibody binds to the tetanus toxin, and has activity of neutralizing the tetanus toxin.
    Type: Application
    Filed: November 19, 2020
    Publication date: April 24, 2025
    Applicants: BEIJING WISDOMAB BIOTECHNOLOGY CO., LTD, GENRIX (SHANGHAI) BIOPHARMACEUTICAL CO. LTD., CHONGQING GENRIX BIOPHARMACEUTICAL CO., LTD.
    Inventors: Zhigang LIU, Xiaowei ZHOU, Yulan LIU, Xiaobo HAO, Junjie HU
  • Patent number: 12132795
    Abstract: Embodiments of this application disclose a data recommendation method performed by a computer device. The data recommendation method includes: obtaining a service object set associated with a target user in a plurality of fields in response to a data recommendation request for the target user in a target field, performing cross-field cross-encoding on the plurality of fields and the service object set to obtain a target field interest feature of the target user in the target field; obtaining to-be-recommended service object features of a plurality of to-be-recommended service objects in the target field; and obtaining a target to-be-recommended service object feature matching with the target field interest feature of the target user from the to-be-recommended service object features, and returning a target to-be-recommended service object corresponding to the target to-be-recommended service object feature to the target user.
    Type: Grant
    Filed: September 19, 2022
    Date of Patent: October 29, 2024
    Assignee: Tencent Technology (Shenzhen) Company Limited
    Inventors: Xiaobo Hao, Kaikai Ge, Yudan Liu, Linyao Tang, Xu Zhang, Ruobing Xie, Leyu Lin
  • Publication number: 20240228605
    Abstract: A bispecific antibody and a monoclonal antibody against human thymic stromal lymphopoietin (TSLP), and a use thereof.
    Type: Application
    Filed: June 17, 2021
    Publication date: July 11, 2024
    Inventors: Xueping ZHANG, Zhigang LIU, Xiaowei ZHOU, Junjie HU, Xiaobo HAO, Yulan LIU
  • Publication number: 20240166725
    Abstract: Provided are an antibody against varicella-zoster virus, a nucleic acid molecule encoding the antibody, an expression vector comprising the nucleic acid molecule, a host cell comprising the nucleic acid molecule or the vector, a method for preparing and purifying the antibody, and the use of the antibody.
    Type: Application
    Filed: January 21, 2022
    Publication date: May 23, 2024
    Inventors: Xueping ZHANG, Zhigang LIU, Xiaowei ZHOU, Xiaobo HAO, Junjie HU, Yulan LIU
  • Publication number: 20240132581
    Abstract: A bispecific antibody and a monoclonal antibody against human thymic stromal lymphopoietin (TSLP), and a use thereof.
    Type: Application
    Filed: June 16, 2021
    Publication date: April 25, 2024
    Inventors: Xueping ZHANG, Zhigang LIU, Xiaowei ZHOU, Junjie HU, Xiaobo HAO, Yulan LIU
  • Patent number: 11897960
    Abstract: Disclosed in the present application are an antibody or an antigen-binding portion thereof binding to human IL-4R, a polynucleotide encoding the antibody or antigen-binding portion thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and the use of the antibody or antigen-binding portion thereof.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: February 13, 2024
    Assignees: Beijing Wisdomab Biotechnology Co., Ltd, Genrix (Shanghai) Biopharmaceutical Co. Ltd., Chongqing Genrix Biopharmaceutical Co., Ltd.
    Inventors: Zhigang Liu, Yulan Liu, Xiaobo Hao, Lei Jiang, Jingjing Guo
  • Patent number: 11773155
    Abstract: The present application provides a bispecific antibody against rabies virus, and an application thereof. The bispecific antibody comprises two antigen-binding fragments binding to different epitopes of G protein of rabies virus, and has rabies virus neutralization activity.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: October 3, 2023
    Assignees: Beijing Wisdomab Biotechnology Co., ltd, GENRIX (Shanghai) Biopharmaceutical Co., Ltd., Chongqing GENRIX Biopharmaceutical Co., Ltd.
    Inventors: Zhigang Liu, Xiaobo Hao, Yulan Liu, Jingjing Guo
  • Publication number: 20230071422
    Abstract: Provided is a bispecific antibody comprising an antigen-binding portion for human CD3E and/or an antigen-binding portion for human CD123. Further provided are the medical and biological uses of the bispecific antibody.
    Type: Application
    Filed: March 30, 2020
    Publication date: March 9, 2023
    Inventors: Zhigang Liu, Xiaobo HAO, Xueping ZHANG, Yulan LIU, Jingjing GUO
  • Publication number: 20230017667
    Abstract: Embodiments of this application disclose a data recommendation method performed by a computer device. The data recommendation method includes: obtaining a service object set associated with a target user in a plurality of fields in response to a data recommendation request for the target user in a target field, performing cross-field cross-encoding on the plurality of fields and the service object set to obtain a target field interest feature of the target user in the target field; obtaining to-be-recommended service object features of a plurality of to-be-recommended service objects in the target field; and obtaining a target to-be-recommended service object feature matching with the target field interest feature of the target user from the to-be-recommended service object features, and returning a target to-be-recommended service object corresponding to the target to-be-recommended service object feature to the target user.
    Type: Application
    Filed: September 19, 2022
    Publication date: January 19, 2023
    Inventors: Xiaobo Hao, Kaikai Ge, Yudan Liu, Linyao Tang, Xu Zhang, Ruobing Xie, Leyu Lin
  • Publication number: 20230009814
    Abstract: Embodiments of this application provide a for training an information recommendation model. The method includes: obtaining historical user behavior data in a plurality of product domains; generating candidate sample data of one or more target product domains according to the historical user behavior data by using a generative model; performing user-specific authenticity sample discrimination on candidate sample data of the target product domains and actual user click sample data by using a discriminative model, to obtain a discrimination result; and performing adversarial training on the generative model and the discriminative model according to the discrimination result, to obtain a trained generative adversarial network as an information recommendation model for a to-be-expanded product domain in the plurality of product domains.
    Type: Application
    Filed: September 19, 2022
    Publication date: January 12, 2023
    Inventors: Xiaobo HAO, Kaikai GE, Yudan LIU, Linyao TANG, Ruobing XIE, Xu ZHANG, Leyu LIN
  • Publication number: 20220081485
    Abstract: Disclosed in the present application are an antibody or an antigen-binding portion thereof binding to human IL-4R, a polynucleotide encoding the antibody or antigen-binding portion thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, a method for preparing and purifying the antibody, and the use of the antibody or antigen-binding portion thereof.
    Type: Application
    Filed: August 13, 2018
    Publication date: March 17, 2022
    Inventors: Zhigang LIU, Yulan LIU, Xiaobo HAO, Lei JIANG, Jingjing GUO
  • Publication number: 20210340224
    Abstract: The present application provides a bispecific antibody against rabies virus, and an application thereof. The bispecific antibody comprises two antigen-binding fragments binding to different epitopes of G protein of rabies virus, and has rabies virus neutralization activity.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 4, 2021
    Inventors: Zhigang LIU, Xiaobo HAO, Yulan LIU, Jingjing GUO